Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity

Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Lei, Yaohui, Bai, Yu, Chu, Daniel, Ni, Zhi-Jie, Wang, John Jian-Xin
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Lei, Yaohui
Bai, Yu
Chu, Daniel
Ni, Zhi-Jie
Wang, John Jian-Xin
description Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
format Patent
fullrecord <record><control><sourceid>uspatents_EFH</sourceid><recordid>TN_cdi_uspatents_grants_07368422</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>07368422</sourcerecordid><originalsourceid>FETCH-uspatents_grants_073684223</originalsourceid><addsrcrecordid>eNqNjcsKwjAQRbNxIeo_5AeC0op2L4p73cs0naYDeZGMlfy9EQS3rg5cDucuxXhDRyoXzxMyaZkQUgJvcJAzeB1c0eS3A2aHPBWrfqPqIVfL2KJDxMhUJfkiniR4pp7CJweaaSYua7EYwWbcfLkS8nK-n67qmSMwes4PU28rdsf20O2bpv1DeQMJYEI8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity</title><source>USPTO Issued Patents</source><creator>Lei, Yaohui ; Bai, Yu ; Chu, Daniel ; Ni, Zhi-Jie ; Wang, John Jian-Xin</creator><creatorcontrib>Lei, Yaohui ; Bai, Yu ; Chu, Daniel ; Ni, Zhi-Jie ; Wang, John Jian-Xin ; Novartis Vaccines and Diagnostics Inc</creatorcontrib><description>Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.</description><language>eng</language><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7368422$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,780,802,885,64037</link.rule.ids><linktorsrc>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7368422$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Lei, Yaohui</creatorcontrib><creatorcontrib>Bai, Yu</creatorcontrib><creatorcontrib>Chu, Daniel</creatorcontrib><creatorcontrib>Ni, Zhi-Jie</creatorcontrib><creatorcontrib>Wang, John Jian-Xin</creatorcontrib><creatorcontrib>Novartis Vaccines and Diagnostics Inc</creatorcontrib><title>Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity</title><description>Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EFH</sourceid><recordid>eNqNjcsKwjAQRbNxIeo_5AeC0op2L4p73cs0naYDeZGMlfy9EQS3rg5cDucuxXhDRyoXzxMyaZkQUgJvcJAzeB1c0eS3A2aHPBWrfqPqIVfL2KJDxMhUJfkiniR4pp7CJweaaSYua7EYwWbcfLkS8nK-n67qmSMwes4PU28rdsf20O2bpv1DeQMJYEI8</recordid><startdate>20080506</startdate><enddate>20080506</enddate><creator>Lei, Yaohui</creator><creator>Bai, Yu</creator><creator>Chu, Daniel</creator><creator>Ni, Zhi-Jie</creator><creator>Wang, John Jian-Xin</creator><scope>EFH</scope></search><sort><creationdate>20080506</creationdate><title>Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity</title><author>Lei, Yaohui ; Bai, Yu ; Chu, Daniel ; Ni, Zhi-Jie ; Wang, John Jian-Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_grants_073684223</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2008</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Lei, Yaohui</creatorcontrib><creatorcontrib>Bai, Yu</creatorcontrib><creatorcontrib>Chu, Daniel</creatorcontrib><creatorcontrib>Ni, Zhi-Jie</creatorcontrib><creatorcontrib>Wang, John Jian-Xin</creatorcontrib><creatorcontrib>Novartis Vaccines and Diagnostics Inc</creatorcontrib><collection>USPTO Issued Patents</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lei, Yaohui</au><au>Bai, Yu</au><au>Chu, Daniel</au><au>Ni, Zhi-Jie</au><au>Wang, John Jian-Xin</au><aucorp>Novartis Vaccines and Diagnostics Inc</aucorp><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity</title><date>2008-05-06</date><risdate>2008</risdate><abstract>Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_uspatents_grants_07368422
source USPTO Issued Patents
title Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T18%3A33%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-uspatents_EFH&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Lei,%20Yaohui&rft.aucorp=Novartis%20Vaccines%20and%20Diagnostics%20Inc&rft.date=2008-05-06&rft_id=info:doi/&rft_dat=%3Cuspatents_EFH%3E07368422%3C/uspatents_EFH%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true