Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/o...
Gespeichert in:
Hauptverfasser: | , , , , |
---|---|
Format: | Patent |
Sprache: | eng |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | |
container_start_page | |
container_title | |
container_volume | |
creator | Lei, Yaohui Bai, Yu Chu, Daniel Ni, Zhi-Jie Wang, John Jian-Xin |
description | Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections. |
format | Patent |
fullrecord | <record><control><sourceid>uspatents_EFH</sourceid><recordid>TN_cdi_uspatents_grants_07368422</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>07368422</sourcerecordid><originalsourceid>FETCH-uspatents_grants_073684223</originalsourceid><addsrcrecordid>eNqNjcsKwjAQRbNxIeo_5AeC0op2L4p73cs0naYDeZGMlfy9EQS3rg5cDucuxXhDRyoXzxMyaZkQUgJvcJAzeB1c0eS3A2aHPBWrfqPqIVfL2KJDxMhUJfkiniR4pp7CJweaaSYua7EYwWbcfLkS8nK-n67qmSMwes4PU28rdsf20O2bpv1DeQMJYEI8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity</title><source>USPTO Issued Patents</source><creator>Lei, Yaohui ; Bai, Yu ; Chu, Daniel ; Ni, Zhi-Jie ; Wang, John Jian-Xin</creator><creatorcontrib>Lei, Yaohui ; Bai, Yu ; Chu, Daniel ; Ni, Zhi-Jie ; Wang, John Jian-Xin ; Novartis Vaccines and Diagnostics Inc</creatorcontrib><description>Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.</description><language>eng</language><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7368422$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,780,802,885,64037</link.rule.ids><linktorsrc>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7368422$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Lei, Yaohui</creatorcontrib><creatorcontrib>Bai, Yu</creatorcontrib><creatorcontrib>Chu, Daniel</creatorcontrib><creatorcontrib>Ni, Zhi-Jie</creatorcontrib><creatorcontrib>Wang, John Jian-Xin</creatorcontrib><creatorcontrib>Novartis Vaccines and Diagnostics Inc</creatorcontrib><title>Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity</title><description>Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EFH</sourceid><recordid>eNqNjcsKwjAQRbNxIeo_5AeC0op2L4p73cs0naYDeZGMlfy9EQS3rg5cDucuxXhDRyoXzxMyaZkQUgJvcJAzeB1c0eS3A2aHPBWrfqPqIVfL2KJDxMhUJfkiniR4pp7CJweaaSYua7EYwWbcfLkS8nK-n67qmSMwes4PU28rdsf20O2bpv1DeQMJYEI8</recordid><startdate>20080506</startdate><enddate>20080506</enddate><creator>Lei, Yaohui</creator><creator>Bai, Yu</creator><creator>Chu, Daniel</creator><creator>Ni, Zhi-Jie</creator><creator>Wang, John Jian-Xin</creator><scope>EFH</scope></search><sort><creationdate>20080506</creationdate><title>Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity</title><author>Lei, Yaohui ; Bai, Yu ; Chu, Daniel ; Ni, Zhi-Jie ; Wang, John Jian-Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_grants_073684223</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2008</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Lei, Yaohui</creatorcontrib><creatorcontrib>Bai, Yu</creatorcontrib><creatorcontrib>Chu, Daniel</creatorcontrib><creatorcontrib>Ni, Zhi-Jie</creatorcontrib><creatorcontrib>Wang, John Jian-Xin</creatorcontrib><creatorcontrib>Novartis Vaccines and Diagnostics Inc</creatorcontrib><collection>USPTO Issued Patents</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lei, Yaohui</au><au>Bai, Yu</au><au>Chu, Daniel</au><au>Ni, Zhi-Jie</au><au>Wang, John Jian-Xin</au><aucorp>Novartis Vaccines and Diagnostics Inc</aucorp><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity</title><date>2008-05-06</date><risdate>2008</risdate><abstract>Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.</abstract><oa>free_for_read</oa></addata></record> |
fulltext | fulltext_linktorsrc |
identifier | |
ispartof | |
issn | |
language | eng |
recordid | cdi_uspatents_grants_07368422 |
source | USPTO Issued Patents |
title | Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T18%3A33%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-uspatents_EFH&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Lei,%20Yaohui&rft.aucorp=Novartis%20Vaccines%20and%20Diagnostics%20Inc&rft.date=2008-05-06&rft_id=info:doi/&rft_dat=%3Cuspatents_EFH%3E07368422%3C/uspatents_EFH%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |