Screening of chemical compounds purified from biological sources

Screening of chemical compounds purified from biological sources

A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed...

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Hauptverfasser: Eldridge, Gary, Zeng, Lu, Cremin, Peader, Lee, Chris, Vervoort, Helene C, Ghanem, Marilyn
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Sprache:eng
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creator Eldridge, Gary
Zeng, Lu
Cremin, Peader
Lee, Chris
Vervoort, Helene C
Ghanem, Marilyn
description A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about −1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.
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title Screening of chemical compounds purified from biological sources
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