Compounds and methods for preparing methanesulfonamides

Compounds and methods for preparing methanesulfonamides

A process for preparing (S)-(−)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4-[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide(IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and e...

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Hauptverfasser: MacKey, Sonja Suzanne, Matison, Michael E, Wu, Haifeng, Goble, Michael Paul, McMillan, Moses W, Kalthod, Vikram Gurudath
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Sprache:eng
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creator MacKey, Sonja Suzanne
Matison, Michael E
Wu, Haifeng
Goble, Michael Paul
McMillan, Moses W
Kalthod, Vikram Gurudath
description A process for preparing (S)-(−)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4-[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide(IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxylphenyl]methanesulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
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title Compounds and methods for preparing methanesulfonamides
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