Methods and compositions of novel triazine compounds

The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associ...

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Bibliographische Detailangaben
Hauptverfasser: Timmer, Richard T, Alexander, Christopher W, Pillarisetti, Sivaram, Saxena, Uday, Yeleswarapu, Koteswar Rao, Pal, Manojit, Reddy, Jangalgar Tirupathy, Reddy, Velagala Venkata Rama Murali Krishna, Sridevi, Bhatlapenumarthy Sesha, Kumar, Potlapally Rajender, Reddy, Gaddam Om
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.