HIV inhibiting pyrazinone derivatives

1 1-41-61-61-62-62-63-71-61-6m21-41-61-61-62 1-456781-6m2-62-61-61-61-61-41-61-611-61-61-61-611111-611-613-73-73-71-61-61-61-41-61-63 4 141-6m12 3 This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Ris hydrogen, hydroxy, cyano, amino, mono-or di(Calkyl)amino, formyl, carboxyl, Calkyl, hydroxyCalkyl, polyhaloCalkyl, Calkenyl, Calkynyl, Ccycloalkyl, Calkyloxy, Calkylcarbonyl, aminocarbonyl, -S(═O)-NH, mono-or di(Calkyl)aminocarbonyl, Calkyloxycarbonyl, Calkylcarbonyloxy, aryl, arylCalkyl or aryloxy; Ris hydrogen; halo; mercapto; formyl; cyano; carboxy; azido; hydroxy; oxiranyl; amino; mono- or di(Calkyl)amino; formylamino; RRN-C(═O)-; R-N═C(R)-; Calkyl-S(═O)m; aryl-S(═O); optionally substituted Calkenyl; optionally substituted Calkynyl; Calkyloxy; hydroxyCalkyloxy; aminoCalkyloxy; mono- or di(Calkyl)amino-Calkyloxy; Calkylcarbonyl; arylcarbonyl; Hetcarbonyl; Calkyloxycarbonyl; Calkylcarbonyloxy; aryl; aryloxy; arylCalkyloxy; arylthio; arylCalkylthio; mono- or di(aryl)amino; Het; Hetoxy; Hetthio; HetCalkyloxy; HetCalkylthio; mono- or di(Het)amino; Ccycloalkyl; Ccycloalkyloxy; Ccycloalkylthio; Calkylthio; hydroxyCalkylthio; aminoCalkylthio; mono- or di(Calkyl)aminoCalkylthio; optionally substituted Calkyl; Ror Reach independently represent optionally be substituted phenyl, pyridyl, pyrimidinyl, pyrazinyl or pyridazinyl; -X- is a bivalent radical selected from -NR-, -NH-NH-, -N═N-, -O-, -Calkanediyl-, -C(═O)-, -CHOH-, -S-, -S(═O)-; aryl is optionally substituted phenyl; Het, Hetor Hetrepresent an optionally substituted monocyclic or bicyclic heterocycle; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.