Cell-based drug screens for regulators of gene expression

The invention provides methods and compositions for screening for pharmacological agents which regulate gene expression in mammals. An exemplary assay involves (a) contacting a mammalian cell comprising a knock-in mutant of a targeted native allele encoding a reporter of gene expression, wherein the...

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Bibliographische Detailangaben

Hauptverfasser:	Shan, Bei, Learned, R. Marc, Amaral, M. Catherine, McKnight, Steven L, de la Brousse, Fabienne C, Chen, Jin-Long
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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