Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives

Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives

The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases ("PKs"). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activ...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Moon, Malcolm Wilson, Morozowich, Walter, Gao, Ping, Tang, Peng Cho
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Moon, Malcolm Wilson
Morozowich, Walter
Gao, Ping
Tang, Peng Cho
description The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases ("PKs"). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
format Patent
fullrecord <record><control><sourceid>uspatents_EFH</sourceid><recordid>TN_cdi_uspatents_grants_07053113</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>07053113</sourcerecordid><originalsourceid>FETCH-uspatents_grants_070531133</originalsourceid><addsrcrecordid>eNqNyrEKwjAQgOEsDqK-w406BFqD-ACiuHRzl9Nc24N4CZe0kLdXwQdw-uDnX5quQxF-jvDATJA0ep2GDLEHZ7epqsZg97YG-6Iy1sCehHafwuJjYIlC4El5xsIz5bVZ9BgybX6uDFzOt9PVTjlhISn5Pih-aY7NwbWtc38sbyZ3Nj4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives</title><source>USPTO Issued Patents</source><creator>Moon, Malcolm Wilson ; Morozowich, Walter ; Gao, Ping ; Tang, Peng Cho</creator><creatorcontrib>Moon, Malcolm Wilson ; Morozowich, Walter ; Gao, Ping ; Tang, Peng Cho ; Pharmacia &amp; Upjohn Company LLC ; Sugen, Inc</creatorcontrib><description>The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases ("PKs"). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.</description><language>eng</language><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7053113$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,777,799,882,64018</link.rule.ids><linktorsrc>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7053113$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Moon, Malcolm Wilson</creatorcontrib><creatorcontrib>Morozowich, Walter</creatorcontrib><creatorcontrib>Gao, Ping</creatorcontrib><creatorcontrib>Tang, Peng Cho</creatorcontrib><creatorcontrib>Pharmacia &amp; Upjohn Company LLC</creatorcontrib><creatorcontrib>Sugen, Inc</creatorcontrib><title>Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives</title><description>The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases ("PKs"). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EFH</sourceid><recordid>eNqNyrEKwjAQgOEsDqK-w406BFqD-ACiuHRzl9Nc24N4CZe0kLdXwQdw-uDnX5quQxF-jvDATJA0ep2GDLEHZ7epqsZg97YG-6Iy1sCehHafwuJjYIlC4El5xsIz5bVZ9BgybX6uDFzOt9PVTjlhISn5Pih-aY7NwbWtc38sbyZ3Nj4</recordid><startdate>20060530</startdate><enddate>20060530</enddate><creator>Moon, Malcolm Wilson</creator><creator>Morozowich, Walter</creator><creator>Gao, Ping</creator><creator>Tang, Peng Cho</creator><scope>EFH</scope></search><sort><creationdate>20060530</creationdate><title>Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives</title><author>Moon, Malcolm Wilson ; Morozowich, Walter ; Gao, Ping ; Tang, Peng Cho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_grants_070531133</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2006</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Moon, Malcolm Wilson</creatorcontrib><creatorcontrib>Morozowich, Walter</creatorcontrib><creatorcontrib>Gao, Ping</creatorcontrib><creatorcontrib>Tang, Peng Cho</creatorcontrib><creatorcontrib>Pharmacia &amp; Upjohn Company LLC</creatorcontrib><creatorcontrib>Sugen, Inc</creatorcontrib><collection>USPTO Issued Patents</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Moon, Malcolm Wilson</au><au>Morozowich, Walter</au><au>Gao, Ping</au><au>Tang, Peng Cho</au><aucorp>Pharmacia &amp; Upjohn Company LLC</aucorp><aucorp>Sugen, Inc</aucorp><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives</title><date>2006-05-30</date><risdate>2006</risdate><abstract>The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases ("PKs"). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_uspatents_grants_07053113
source USPTO Issued Patents
title Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T16%3A56%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-uspatents_EFH&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Moon,%20Malcolm%20Wilson&rft.aucorp=Pharmacia%20&%20Upjohn%20Company%20LLC&rft.date=2006-05-30&rft_id=info:doi/&rft_dat=%3Cuspatents_EFH%3E07053113%3C/uspatents_EFH%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true