Heterocyclic side chain containing, n-substituted metalloprotease inhibitors

Heterocyclic side chain containing, n-substituted metalloprotease inhibitors

123Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where R, R, R, n, A, E, X, G, G′, M and Z have t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Pikul, Stanislaw, Ohler, Norman Eugene, Almstead, Neil Gregory, Laughlin, Steven Karl, Natchus, Michael George, De, Biswanath, Hershberger, Paul Mitchell
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Pikul, Stanislaw
Ohler, Norman Eugene
Almstead, Neil Gregory
Laughlin, Steven Karl
Natchus, Michael George
De, Biswanath
Hershberger, Paul Mitchell
description 123Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where R, R, R, n, A, E, X, G, G′, M and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
format Patent
fullrecord <record><control><sourceid>uspatents_EFH</sourceid><recordid>TN_cdi_uspatents_grants_06949545</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>06949545</sourcerecordid><originalsourceid>FETCH-uspatents_grants_069495453</originalsourceid><addsrcrecordid>eNqNyrEKwkAMANBbHET9h3yABcFW6CxKB0d3Sa-xDVyTcskN_r0KfoDTW9463DpyyhpfMXEE44EgTsgCUcU_sox7kMpKb85enAaYyTElXbI6oRGwTNyza7ZtWD0xGe1-bgJcL_dzVxVb0EncHmPGL4dTW7dN3Rz_KG_Afze4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Heterocyclic side chain containing, n-substituted metalloprotease inhibitors</title><source>USPTO Issued Patents</source><creator>Pikul, Stanislaw ; Ohler, Norman Eugene ; Almstead, Neil Gregory ; Laughlin, Steven Karl ; Natchus, Michael George ; De, Biswanath ; Hershberger, Paul Mitchell</creator><creatorcontrib>Pikul, Stanislaw ; Ohler, Norman Eugene ; Almstead, Neil Gregory ; Laughlin, Steven Karl ; Natchus, Michael George ; De, Biswanath ; Hershberger, Paul Mitchell ; The Procter &amp; Gamble Company</creatorcontrib><description>123Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where R, R, R, n, A, E, X, G, G′, M and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.</description><language>eng</language><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6949545$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,776,798,881,64012</link.rule.ids><linktorsrc>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6949545$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Pikul, Stanislaw</creatorcontrib><creatorcontrib>Ohler, Norman Eugene</creatorcontrib><creatorcontrib>Almstead, Neil Gregory</creatorcontrib><creatorcontrib>Laughlin, Steven Karl</creatorcontrib><creatorcontrib>Natchus, Michael George</creatorcontrib><creatorcontrib>De, Biswanath</creatorcontrib><creatorcontrib>Hershberger, Paul Mitchell</creatorcontrib><creatorcontrib>The Procter &amp; Gamble Company</creatorcontrib><title>Heterocyclic side chain containing, n-substituted metalloprotease inhibitors</title><description>123Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where R, R, R, n, A, E, X, G, G′, M and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EFH</sourceid><recordid>eNqNyrEKwkAMANBbHET9h3yABcFW6CxKB0d3Sa-xDVyTcskN_r0KfoDTW9463DpyyhpfMXEE44EgTsgCUcU_sox7kMpKb85enAaYyTElXbI6oRGwTNyza7ZtWD0xGe1-bgJcL_dzVxVb0EncHmPGL4dTW7dN3Rz_KG_Afze4</recordid><startdate>20050927</startdate><enddate>20050927</enddate><creator>Pikul, Stanislaw</creator><creator>Ohler, Norman Eugene</creator><creator>Almstead, Neil Gregory</creator><creator>Laughlin, Steven Karl</creator><creator>Natchus, Michael George</creator><creator>De, Biswanath</creator><creator>Hershberger, Paul Mitchell</creator><scope>EFH</scope></search><sort><creationdate>20050927</creationdate><title>Heterocyclic side chain containing, n-substituted metalloprotease inhibitors</title><author>Pikul, Stanislaw ; Ohler, Norman Eugene ; Almstead, Neil Gregory ; Laughlin, Steven Karl ; Natchus, Michael George ; De, Biswanath ; Hershberger, Paul Mitchell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_grants_069495453</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2005</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Pikul, Stanislaw</creatorcontrib><creatorcontrib>Ohler, Norman Eugene</creatorcontrib><creatorcontrib>Almstead, Neil Gregory</creatorcontrib><creatorcontrib>Laughlin, Steven Karl</creatorcontrib><creatorcontrib>Natchus, Michael George</creatorcontrib><creatorcontrib>De, Biswanath</creatorcontrib><creatorcontrib>Hershberger, Paul Mitchell</creatorcontrib><creatorcontrib>The Procter &amp; Gamble Company</creatorcontrib><collection>USPTO Issued Patents</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Pikul, Stanislaw</au><au>Ohler, Norman Eugene</au><au>Almstead, Neil Gregory</au><au>Laughlin, Steven Karl</au><au>Natchus, Michael George</au><au>De, Biswanath</au><au>Hershberger, Paul Mitchell</au><aucorp>The Procter &amp; Gamble Company</aucorp><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Heterocyclic side chain containing, n-substituted metalloprotease inhibitors</title><date>2005-09-27</date><risdate>2005</risdate><abstract>123Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where R, R, R, n, A, E, X, G, G′, M and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_uspatents_grants_06949545
source USPTO Issued Patents
title Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T02%3A20%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-uspatents_EFH&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Pikul,%20Stanislaw&rft.aucorp=The%20Procter%20&%20Gamble%20Company&rft.date=2005-09-27&rft_id=info:doi/&rft_dat=%3Cuspatents_EFH%3E06949545%3C/uspatents_EFH%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true