Nitric oxide-releasing metallic medical devices

Nitric oxide-releasing metallic medical devices

Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Fitzhugh, Anthony L, Cheng, Peiwen, Saavedra, Joseph, Cafferata, Robert, Hendriks, Marc, Keefer, Larry K, Tedeschi, Eugene, Verhoeven, Michel I. P. M
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Fitzhugh, Anthony L
Cheng, Peiwen
Saavedra, Joseph
Cafferata, Robert
Hendriks, Marc
Keefer, Larry K
Tedeschi, Eugene
Verhoeven, Michel I. P. M
description Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.
format Patent
fullrecord <record><control><sourceid>uspatents_EFH</sourceid><recordid>TN_cdi_uspatents_grants_06887485</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>06887485</sourcerecordid><originalsourceid>FETCH-uspatents_grants_068874853</originalsourceid><addsrcrecordid>eNrjZND3yywpykxWyK_ITEnVLUrNSU0szsxLV8hNLUnMyQFK5KamZCYn5iikpJZlJqcW8zCwpiXmFKfyQmluBgU31xBnD93S4oLEktS8kuL49KJEEGVgZmFhbmJhakyEEgAQvywG</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Nitric oxide-releasing metallic medical devices</title><source>USPTO Issued Patents</source><creator>Fitzhugh, Anthony L ; Cheng, Peiwen ; Saavedra, Joseph ; Cafferata, Robert ; Hendriks, Marc ; Keefer, Larry K ; Tedeschi, Eugene ; Verhoeven, Michel I. P. M</creator><creatorcontrib>Fitzhugh, Anthony L ; Cheng, Peiwen ; Saavedra, Joseph ; Cafferata, Robert ; Hendriks, Marc ; Keefer, Larry K ; Tedeschi, Eugene ; Verhoeven, Michel I. P. M ; Medtronic Vascular, Inc ; The United States of America as represented by the Department of Health and Human Services</creatorcontrib><description>Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.</description><language>eng</language><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6887485$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,776,798,881,64012</link.rule.ids><linktorsrc>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6887485$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Fitzhugh, Anthony L</creatorcontrib><creatorcontrib>Cheng, Peiwen</creatorcontrib><creatorcontrib>Saavedra, Joseph</creatorcontrib><creatorcontrib>Cafferata, Robert</creatorcontrib><creatorcontrib>Hendriks, Marc</creatorcontrib><creatorcontrib>Keefer, Larry K</creatorcontrib><creatorcontrib>Tedeschi, Eugene</creatorcontrib><creatorcontrib>Verhoeven, Michel I. P. M</creatorcontrib><creatorcontrib>Medtronic Vascular, Inc</creatorcontrib><creatorcontrib>The United States of America as represented by the Department of Health and Human Services</creatorcontrib><title>Nitric oxide-releasing metallic medical devices</title><description>Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EFH</sourceid><recordid>eNrjZND3yywpykxWyK_ITEnVLUrNSU0szsxLV8hNLUnMyQFK5KamZCYn5iikpJZlJqcW8zCwpiXmFKfyQmluBgU31xBnD93S4oLEktS8kuL49KJEEGVgZmFhbmJhakyEEgAQvywG</recordid><startdate>20050503</startdate><enddate>20050503</enddate><creator>Fitzhugh, Anthony L</creator><creator>Cheng, Peiwen</creator><creator>Saavedra, Joseph</creator><creator>Cafferata, Robert</creator><creator>Hendriks, Marc</creator><creator>Keefer, Larry K</creator><creator>Tedeschi, Eugene</creator><creator>Verhoeven, Michel I. P. M</creator><scope>EFH</scope></search><sort><creationdate>20050503</creationdate><title>Nitric oxide-releasing metallic medical devices</title><author>Fitzhugh, Anthony L ; Cheng, Peiwen ; Saavedra, Joseph ; Cafferata, Robert ; Hendriks, Marc ; Keefer, Larry K ; Tedeschi, Eugene ; Verhoeven, Michel I. P. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_grants_068874853</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2005</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Fitzhugh, Anthony L</creatorcontrib><creatorcontrib>Cheng, Peiwen</creatorcontrib><creatorcontrib>Saavedra, Joseph</creatorcontrib><creatorcontrib>Cafferata, Robert</creatorcontrib><creatorcontrib>Hendriks, Marc</creatorcontrib><creatorcontrib>Keefer, Larry K</creatorcontrib><creatorcontrib>Tedeschi, Eugene</creatorcontrib><creatorcontrib>Verhoeven, Michel I. P. M</creatorcontrib><creatorcontrib>Medtronic Vascular, Inc</creatorcontrib><creatorcontrib>The United States of America as represented by the Department of Health and Human Services</creatorcontrib><collection>USPTO Issued Patents</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Fitzhugh, Anthony L</au><au>Cheng, Peiwen</au><au>Saavedra, Joseph</au><au>Cafferata, Robert</au><au>Hendriks, Marc</au><au>Keefer, Larry K</au><au>Tedeschi, Eugene</au><au>Verhoeven, Michel I. P. M</au><aucorp>Medtronic Vascular, Inc</aucorp><aucorp>The United States of America as represented by the Department of Health and Human Services</aucorp><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Nitric oxide-releasing metallic medical devices</title><date>2005-05-03</date><risdate>2005</risdate><abstract>Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_uspatents_grants_06887485
source USPTO Issued Patents
title Nitric oxide-releasing metallic medical devices
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T17%3A04%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-uspatents_EFH&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Fitzhugh,%20Anthony%20L&rft.aucorp=Medtronic%20Vascular,%20Inc&rft.date=2005-05-03&rft_id=info:doi/&rft_dat=%3Cuspatents_EFH%3E06887485%3C/uspatents_EFH%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true