Means and methods for fibroblast-like or macrophage-like cell transduction

Means and methods for fibroblast-like or macrophage-like cell transduction

The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for fibroblast-like or macrophage-like cells, preferably synoviocytes. In one aspect the nucleic acid delivery vehicle is a virus capsid or a functional part, derivative and/or analogue...

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Hauptverfasser: Vogels, Ronald, Schouten, Govert J, Bout, Abraham, Havenga, Menzo Jans Emco
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Sprache:eng
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creator Vogels, Ronald
Schouten, Govert J
Bout, Abraham
Havenga, Menzo Jans Emco
description The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for fibroblast-like or macrophage-like cells, preferably synoviocytes. In one aspect the nucleic acid delivery vehicle is a virus capsid or a functional part, derivative and/or analogue thereof. Preferably, the virus capsid is an adenovirus capsid. Preferably, the adenovirus is a subgroup B adenovirus, preferably adenovirus 16. Preferably, the tissue tropism is provided by at least a tissue tropism determining part of an adenovirus fiber protein or a functional derivative and/or analogue thereof. The invention further presents methods for the treatment of diseases, preferably joint related diseases.
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title Means and methods for fibroblast-like or macrophage-like cell transduction
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