Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

1 2 2223 4 5 6 This invention provides compounds of the formula: wherein Rand Rare each, independently, H, alkyl, cycloalkyl, -CH-cycloalkyl, alkoxy, halogen, fluorinated alkyl, -CN, -NH-SO-alkyl, -SO-NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, or phenoyl or thiophenoyl; Rand Rare each, independently, H, alkyl or cycloalkyl; Ris H or alkyl; Ris H or; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions and methods utilizing these compounds for the treatment or prevention of disorders including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.