Process for the preparation of fluorosteroids
The present invention refers to a stereoselective process for the preparation of 6 -fluorosteroids of formula (I) reported hereinafter, useful in the preparation of anti-inflammatory pharmaceutical formulations. Described herein is a process for the preparation of 6 -fluorosteroids of formula (I), i...
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| creator | La Loggia, Filippo Da Col, Marco |
| description | The present invention refers to a stereoselective process for the preparation of 6 -fluorosteroids of formula (I) reported hereinafter, useful in the preparation of anti-inflammatory pharmaceutical formulations.
Described herein is a process for the preparation of 6 -fluorosteroids of formula (I), in which R is chosen from H, OH and an alkyl group with from 1 to 4 carbon atoms and R′ is a carboxyalkyl group with from 1 to 4 carbon atoms in the alkyl chain, comprising the selective fluorination at the 6 -position by treatment of the compound of formula (III), wherein R and R′ are as defined above, with an electrophilic fluorinating agent. |
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Described herein is a process for the preparation of 6 -fluorosteroids of formula (I), in which R is chosen from H, OH and an alkyl group with from 1 to 4 carbon atoms and R′ is a carboxyalkyl group with from 1 to 4 carbon atoms in the alkyl chain, comprising the selective fluorination at the 6 -position by treatment of the compound of formula (III), wherein R and R′ are as defined above, with an electrophilic fluorinating agent.</description><language>eng</language><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6794503$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,780,802,885,64039</link.rule.ids><linktorsrc>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6794503$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>La Loggia, Filippo</creatorcontrib><creatorcontrib>Da Col, Marco</creatorcontrib><creatorcontrib>Farmabios S.r.l</creatorcontrib><title>Process for the preparation of fluorosteroids</title><description>The present invention refers to a stereoselective process for the preparation of 6 -fluorosteroids of formula (I) reported hereinafter, useful in the preparation of anti-inflammatory pharmaceutical formulations.
Described herein is a process for the preparation of 6 -fluorosteroids of formula (I), in which R is chosen from H, OH and an alkyl group with from 1 to 4 carbon atoms and R′ is a carboxyalkyl group with from 1 to 4 carbon atoms in the alkyl chain, comprising the selective fluorination at the 6 -position by treatment of the compound of formula (III), wherein R and R′ are as defined above, with an electrophilic fluorinating agent.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EFH</sourceid><recordid>eNrjZNANKMpPTi0uVkjLL1IoyUhVKChKLUgsSizJzM9TyE9TSMspzS_KLy5JLcrPTCnmYWBNS8wpTuWF0twMCm6uIc4euqXFBYklqXklxfHpRYkgysDM3NLE1MDYmAglAMlZK4s</recordid><startdate>20040921</startdate><enddate>20040921</enddate><creator>La Loggia, Filippo</creator><creator>Da Col, Marco</creator><scope>EFH</scope></search><sort><creationdate>20040921</creationdate><title>Process for the preparation of fluorosteroids</title><author>La Loggia, Filippo ; Da Col, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_grants_067945033</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2004</creationdate><toplevel>online_resources</toplevel><creatorcontrib>La Loggia, Filippo</creatorcontrib><creatorcontrib>Da Col, Marco</creatorcontrib><creatorcontrib>Farmabios S.r.l</creatorcontrib><collection>USPTO Issued Patents</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>La Loggia, Filippo</au><au>Da Col, Marco</au><aucorp>Farmabios S.r.l</aucorp><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for the preparation of fluorosteroids</title><date>2004-09-21</date><risdate>2004</risdate><abstract>The present invention refers to a stereoselective process for the preparation of 6 -fluorosteroids of formula (I) reported hereinafter, useful in the preparation of anti-inflammatory pharmaceutical formulations.
Described herein is a process for the preparation of 6 -fluorosteroids of formula (I), in which R is chosen from H, OH and an alkyl group with from 1 to 4 carbon atoms and R′ is a carboxyalkyl group with from 1 to 4 carbon atoms in the alkyl chain, comprising the selective fluorination at the 6 -position by treatment of the compound of formula (III), wherein R and R′ are as defined above, with an electrophilic fluorinating agent.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Process for the preparation of fluorosteroids |
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