Chemokine receptor binding heterocyclic compounds

Chemokine receptor binding heterocyclic compounds

This invention generally relates to novel compounds, pharmaceutical compositions and their use. This invention more specifically relates to novel heterocyclic compounds that bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by...

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Bibliographische Detailangaben
Hauptverfasser: Bridger, Gary, Skerlj, Renato, Kaller, Al, Harwig, Curtis, Bogucki, David, Wilson, Trevor R, Crawford, Jason, McEachern, Ernest J, Atsma, Bern, Nan, Siqiao, Zhou, Yuanxi, Schols, Dominique, Dennis, Christopher, Di Fluri, Rosaria Maria
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
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Beschreibung
Zusammenfassung:This invention generally relates to novel compounds, pharmaceutical compositions and their use. This invention more specifically relates to novel heterocyclic compounds that bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV). Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole.