8-hydroxy-7-substituted quinolines as anti-viral agents

8-hydroxy-7-substituted quinolines as anti-viral agents

The present invention provides for 8-hydroxy-7-substituted quinoline compounds and pharmaceutically acceptable salts thereof which are useful as antiviral agents. The invention also relates to a pharmaceutical composition containing such compound in combination with a suitable excipient, the composi...

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Hauptverfasser: Vaillancourt, Valerie Ann, Strohbach, Joseph Walter, Bezencon, Olivier, Thaisrivongs, Suvit
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Sprache:eng
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creator Vaillancourt, Valerie Ann
Strohbach, Joseph Walter
Bezencon, Olivier
Thaisrivongs, Suvit
description The present invention provides for 8-hydroxy-7-substituted quinoline compounds and pharmaceutically acceptable salts thereof which are useful as antiviral agents. The invention also relates to a pharmaceutical composition containing such compound in combination with a suitable excipient, the composition being useful in combating viral infections. The invention also relates to a method for selectively combating viral infections in animals, including man. Specifically, these compounds have anti-viral activity against the herpes virus, cytomegalovirus (CMV). Many of these compounds are also active against other herpes viruses, such as the varicella zoster virus, the Epstein-Barr virus, the herpes simplex virus, and the human herpes virus type 8 (HHV-8). The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula IA These compounds are useful as anti-viral agents. Specifically, these compounds have anti-viral activity against the herpes virus, cytomegalovirus (CMV). Many of these compounds are also active against other herpes viruses, such as the varicella zoster virus, the Epstein-Barr virus, the herpes simplex virus and the human herpes virus type 8 (HHV-8).
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title 8-hydroxy-7-substituted quinolines as anti-viral agents
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