Process for water soluble azole compounds

Process for water soluble azole compounds

This invention relates to an improved process for preparing certain water-soluble azole compounds useful in the treatment of serious systemic fungal infections. More particularly, the present invention relates to an improved process for preparing the water-soluble prodrugs having the general formula...

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Hauptverfasser: Chen, Chung-Pin, Connolly, Timothy Paul, Kolla, Laxma Reddy, Matiskella, John D, Mueller, Richard H, Pendri, Yadagiri, Petsch, Dejah T
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Sprache:eng
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creator Chen, Chung-Pin
Connolly, Timothy Paul
Kolla, Laxma Reddy
Matiskella, John D
Mueller, Richard H
Pendri, Yadagiri
Petsch, Dejah T
description This invention relates to an improved process for preparing certain water-soluble azole compounds useful in the treatment of serious systemic fungal infections. More particularly, the present invention relates to an improved process for preparing the water-soluble prodrugs having the general formula An improved process is provided for preparing water-soluble prodrugs of triazole antifungal compounds containing a secondary or tertiary hydroxyl group. More particularly, the improved process is directed toward preparation of water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and R and Rare as defined in the specification.
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title Process for water soluble azole compounds
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