Hydantoin compounds and methods related thereto
The present invention relates to a novel hydantoin derivative represented by the following formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an effective therapeutic agent against anti-proliferative diseases such as resfenosis, Rheumatitis arthritit...
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| creator | Lee, Jin Ho Koh, Jong Sung Kim, Jong Hyun Lee, Hyun Il Jung, Won Hee Ro, Seong Gu Shin, You Seong Kim, Sang Woong Park, Ki Won Kwak, Tae Hwan Moon, Kyung Duk Chung, Hyun Ho |
| description | The present invention relates to a novel hydantoin derivative represented by the following formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an effective therapeutic agent against anti-proliferative diseases such as resfenosis, Rheumatitis arthrititis and particularly cancer:
The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R, R, Rand Rare as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient. |
| format | Patent |
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The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R, R, Rand Rare as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.</description><language>eng</language><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6384061$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,776,798,881,64016</link.rule.ids><linktorsrc>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6384061$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Lee, Jin Ho</creatorcontrib><creatorcontrib>Koh, Jong Sung</creatorcontrib><creatorcontrib>Kim, Jong Hyun</creatorcontrib><creatorcontrib>Lee, Hyun Il</creatorcontrib><creatorcontrib>Jung, Won Hee</creatorcontrib><creatorcontrib>Ro, Seong Gu</creatorcontrib><creatorcontrib>Shin, You Seong</creatorcontrib><creatorcontrib>Kim, Sang Woong</creatorcontrib><creatorcontrib>Park, Ki Won</creatorcontrib><creatorcontrib>Kwak, Tae Hwan</creatorcontrib><creatorcontrib>Moon, Kyung Duk</creatorcontrib><creatorcontrib>Chung, Hyun Ho</creatorcontrib><creatorcontrib>LG Chemical Ltd</creatorcontrib><title>Hydantoin compounds and methods related thereto</title><description>The present invention relates to a novel hydantoin derivative represented by the following formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an effective therapeutic agent against anti-proliferative diseases such as resfenosis, Rheumatitis arthrititis and particularly cancer:
The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R, R, Rand Rare as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EFH</sourceid><recordid>eNrjZND3qExJzCvJz8xTSM7PLcgvzUspVkjMS1HITS3JyAeyi1JzEktSUxRKMlKLUkvyeRhY0xJzilN5oTQ3g4Kba4izh25pcQFQXV5JcXx6USKIMjAztjAxMDM0JkIJACqNLCU</recordid><startdate>20020507</startdate><enddate>20020507</enddate><creator>Lee, Jin Ho</creator><creator>Koh, Jong Sung</creator><creator>Kim, Jong Hyun</creator><creator>Lee, Hyun Il</creator><creator>Jung, Won Hee</creator><creator>Ro, Seong Gu</creator><creator>Shin, You Seong</creator><creator>Kim, Sang Woong</creator><creator>Park, Ki Won</creator><creator>Kwak, Tae Hwan</creator><creator>Moon, Kyung Duk</creator><creator>Chung, Hyun Ho</creator><scope>EFH</scope></search><sort><creationdate>20020507</creationdate><title>Hydantoin compounds and methods related thereto</title><author>Lee, Jin Ho ; Koh, Jong Sung ; Kim, Jong Hyun ; Lee, Hyun Il ; Jung, Won Hee ; Ro, Seong Gu ; Shin, You Seong ; Kim, Sang Woong ; Park, Ki Won ; Kwak, Tae Hwan ; Moon, Kyung Duk ; Chung, Hyun Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_grants_063840613</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2002</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jin Ho</creatorcontrib><creatorcontrib>Koh, Jong Sung</creatorcontrib><creatorcontrib>Kim, Jong Hyun</creatorcontrib><creatorcontrib>Lee, Hyun Il</creatorcontrib><creatorcontrib>Jung, Won Hee</creatorcontrib><creatorcontrib>Ro, Seong Gu</creatorcontrib><creatorcontrib>Shin, You Seong</creatorcontrib><creatorcontrib>Kim, Sang Woong</creatorcontrib><creatorcontrib>Park, Ki Won</creatorcontrib><creatorcontrib>Kwak, Tae Hwan</creatorcontrib><creatorcontrib>Moon, Kyung Duk</creatorcontrib><creatorcontrib>Chung, Hyun Ho</creatorcontrib><creatorcontrib>LG Chemical Ltd</creatorcontrib><collection>USPTO Issued Patents</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lee, Jin Ho</au><au>Koh, Jong Sung</au><au>Kim, Jong Hyun</au><au>Lee, Hyun Il</au><au>Jung, Won Hee</au><au>Ro, Seong Gu</au><au>Shin, You Seong</au><au>Kim, Sang Woong</au><au>Park, Ki Won</au><au>Kwak, Tae Hwan</au><au>Moon, Kyung Duk</au><au>Chung, Hyun Ho</au><aucorp>LG Chemical Ltd</aucorp><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Hydantoin compounds and methods related thereto</title><date>2002-05-07</date><risdate>2002</risdate><abstract>The present invention relates to a novel hydantoin derivative represented by the following formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an effective therapeutic agent against anti-proliferative diseases such as resfenosis, Rheumatitis arthrititis and particularly cancer:
The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R, R, Rand Rare as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Hydantoin compounds and methods related thereto |
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