VEGF-binding KDR polypeptide
The present invention relates to polypeptides which are useful as neovascularization inhibitors, and a method of producing them. A novel polypeptide is provided, which can be utilized to treat diseases accompanying neovascularization, such as solid tumors, and is useful as a low molecular weight VEG...
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| creator | Niwa, Mikio Okamoto, Masaji Matsumoto, Tomoe Segawa, Toshiaki |
| description | The present invention relates to polypeptides which are useful as neovascularization inhibitors, and a method of producing them.
A novel polypeptide is provided, which can be utilized to treat diseases accompanying neovascularization, such as solid tumors, and is useful as a low molecular weight VEGF inhibitor. The polypeptide contains immunoglobulin-like domain 1 and immunoglobulin-like domain 2 of the extracellular domain of the VEGF receptor KDR. Since it has smaller molecular weight than the conventional polypeptides with retaining VEGF inhibitory activity, it is expected that it can be readily expressed using recombinant DNA techniques and infiltrates into diseased sites more quickly. |
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A novel polypeptide is provided, which can be utilized to treat diseases accompanying neovascularization, such as solid tumors, and is useful as a low molecular weight VEGF inhibitor. The polypeptide contains immunoglobulin-like domain 1 and immunoglobulin-like domain 2 of the extracellular domain of the VEGF receptor KDR. Since it has smaller molecular weight than the conventional polypeptides with retaining VEGF inhibitory activity, it is expected that it can be readily expressed using recombinant DNA techniques and infiltrates into diseased sites more quickly.</description><language>eng</language><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6348333$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,780,802,885,64037</link.rule.ids><linktorsrc>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6348333$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Niwa, Mikio</creatorcontrib><creatorcontrib>Okamoto, Masaji</creatorcontrib><creatorcontrib>Matsumoto, Tomoe</creatorcontrib><creatorcontrib>Segawa, Toshiaki</creatorcontrib><creatorcontrib>Toa Gosei Co., Ltd</creatorcontrib><title>VEGF-binding KDR polypeptide</title><description>The present invention relates to polypeptides which are useful as neovascularization inhibitors, and a method of producing them.
A novel polypeptide is provided, which can be utilized to treat diseases accompanying neovascularization, such as solid tumors, and is useful as a low molecular weight VEGF inhibitor. The polypeptide contains immunoglobulin-like domain 1 and immunoglobulin-like domain 2 of the extracellular domain of the VEGF receptor KDR. Since it has smaller molecular weight than the conventional polypeptides with retaining VEGF inhibitory activity, it is expected that it can be readily expressed using recombinant DNA techniques and infiltrates into diseased sites more quickly.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EFH</sourceid><recordid>eNrjZJAJc3V3003KzEvJzEtX8HYJUijIz6ksSC0oyUxJ5WFgTUvMKU7lhdLcDApuriHOHrqlxQWJJal5JcXx6UWJIMrAzNjEwhgIiFACADUJI-0</recordid><startdate>20020219</startdate><enddate>20020219</enddate><creator>Niwa, Mikio</creator><creator>Okamoto, Masaji</creator><creator>Matsumoto, Tomoe</creator><creator>Segawa, Toshiaki</creator><scope>EFH</scope></search><sort><creationdate>20020219</creationdate><title>VEGF-binding KDR polypeptide</title><author>Niwa, Mikio ; Okamoto, Masaji ; Matsumoto, Tomoe ; Segawa, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_grants_063483333</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2002</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Niwa, Mikio</creatorcontrib><creatorcontrib>Okamoto, Masaji</creatorcontrib><creatorcontrib>Matsumoto, Tomoe</creatorcontrib><creatorcontrib>Segawa, Toshiaki</creatorcontrib><creatorcontrib>Toa Gosei Co., Ltd</creatorcontrib><collection>USPTO Issued Patents</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Niwa, Mikio</au><au>Okamoto, Masaji</au><au>Matsumoto, Tomoe</au><au>Segawa, Toshiaki</au><aucorp>Toa Gosei Co., Ltd</aucorp><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>VEGF-binding KDR polypeptide</title><date>2002-02-19</date><risdate>2002</risdate><abstract>The present invention relates to polypeptides which are useful as neovascularization inhibitors, and a method of producing them.
A novel polypeptide is provided, which can be utilized to treat diseases accompanying neovascularization, such as solid tumors, and is useful as a low molecular weight VEGF inhibitor. The polypeptide contains immunoglobulin-like domain 1 and immunoglobulin-like domain 2 of the extracellular domain of the VEGF receptor KDR. Since it has smaller molecular weight than the conventional polypeptides with retaining VEGF inhibitory activity, it is expected that it can be readily expressed using recombinant DNA techniques and infiltrates into diseased sites more quickly.</abstract><oa>free_for_read</oa></addata></record> |
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| title | VEGF-binding KDR polypeptide |
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