Protein having antithrombotic activity and method for producing the same

Protein having antithrombotic activity and method for producing the same

A method for producing a protein having an antithrombotic activity, which comprises replacing, in a protein that has an amino acid sequence having a homology of not.less than 30% to the amino acid sequence of SEQ ID NO: 1 and forms a higher order structure composed of a first strand ( 1), a first a...

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Hauptverfasser: Kito, Morikazu, Fukuchi, Naoyuki, Kayahara, Takashi, Futaki, Fumie, Ishikawa, Kohki, Suzuki, Eiichiro, Gondoh, Keiko, Shimba, Nobuhisa, Yamada, Naoyuki
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creator Kito, Morikazu
Fukuchi, Naoyuki
Kayahara, Takashi
Futaki, Fumie
Ishikawa, Kohki
Suzuki, Eiichiro
Gondoh, Keiko
Shimba, Nobuhisa
Yamada, Naoyuki
description A method for producing a protein having an antithrombotic activity, which comprises replacing, in a protein that has an amino acid sequence having a homology of not.less than 30% to the amino acid sequence of SEQ ID NO: 1 and forms a higher order structure composed of a first strand ( 1), a first a helix ( 1), a second helix ( 2), a second strand ( 2), a loop, a third strand ( 3), a fourth strand ( 4) and a fifth strand ( 5) in this order from the amino terminus, at least one amino acid residue in a region from 2 to 2 and/or a region from 3 to 4 so that electric charge of the amino acid residue is changed towards positive direction.
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title Protein having antithrombotic activity and method for producing the same
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