Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith

Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith

The present invention relates to a process for making a biologically active substance or therapeutic agent free of a chlorotrityl chloride linker-resin. The process includes reacting an activated amino acid or activated amino acid derivative with a substituted or unsubstituted trityl alcohol resin t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Bohling, James, Maikner, John, Kinzey, Marlin, Ziarno, Witold
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Bohling, James
Maikner, John
Kinzey, Marlin
Ziarno, Witold
description The present invention relates to a process for making a biologically active substance or therapeutic agent free of a chlorotrityl chloride linker-resin. The process includes reacting an activated amino acid or activated amino acid derivative with a substituted or unsubstituted trityl alcohol resin to obtain a resin-CT-AA product; and, reacting the resin-CT-AA product with other building blocks of the biologically active substance or therapeutic agent to obtain said biologically active substance or therapeutic. A product created by this process is also provided herein. The invention is particularly useful to create T-20 and T-1249 therapeutics.
format Patent
fullrecord <record><control><sourceid>uspatents_EFI</sourceid><recordid>TN_cdi_uspatents_applications_20040158037</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20040158037</sourcerecordid><originalsourceid>FETCH-uspatents_applications_200401580373</originalsourceid><addsrcrecordid>eNqVTksOAUEQnY2F4A61lZCMX9iKEAewl9JdTCU1XZ2pGuJUrohwAFYv7-X9usVjXXNSwMARRDFSBG_Y7wIoQSsVaMg42Qhq8koj6Blyo7ENzpreDH8rAEwRTqyiFw4ocn9FnK8E1p7MMQX6WLyiBjO1zsG-S_RR6cZe9YvOGcVo8MVeMdxtD5v9uLWMTsntiDnLa-L9z47TspyXk8WqnC1n_3ifbwBiqg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith</title><source>USPTO Published Applications</source><creator>Bohling, James ; Maikner, John ; Kinzey, Marlin ; Ziarno, Witold</creator><creatorcontrib>Bohling, James ; Maikner, John ; Kinzey, Marlin ; Ziarno, Witold</creatorcontrib><description>The present invention relates to a process for making a biologically active substance or therapeutic agent free of a chlorotrityl chloride linker-resin. The process includes reacting an activated amino acid or activated amino acid derivative with a substituted or unsubstituted trityl alcohol resin to obtain a resin-CT-AA product; and, reacting the resin-CT-AA product with other building blocks of the biologically active substance or therapeutic agent to obtain said biologically active substance or therapeutic. A product created by this process is also provided herein. The invention is particularly useful to create T-20 and T-1249 therapeutics.</description><language>eng</language><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040158037$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,780,873,885,64057</link.rule.ids><linktorsrc>$$Uhttps://patentcenter.uspto.gov/applications/10762401$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Bohling, James</creatorcontrib><creatorcontrib>Maikner, John</creatorcontrib><creatorcontrib>Kinzey, Marlin</creatorcontrib><creatorcontrib>Ziarno, Witold</creatorcontrib><title>Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith</title><description>The present invention relates to a process for making a biologically active substance or therapeutic agent free of a chlorotrityl chloride linker-resin. The process includes reacting an activated amino acid or activated amino acid derivative with a substituted or unsubstituted trityl alcohol resin to obtain a resin-CT-AA product; and, reacting the resin-CT-AA product with other building blocks of the biologically active substance or therapeutic agent to obtain said biologically active substance or therapeutic. A product created by this process is also provided herein. The invention is particularly useful to create T-20 and T-1249 therapeutics.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EFI</sourceid><recordid>eNqVTksOAUEQnY2F4A61lZCMX9iKEAewl9JdTCU1XZ2pGuJUrohwAFYv7-X9usVjXXNSwMARRDFSBG_Y7wIoQSsVaMg42Qhq8koj6Blyo7ENzpreDH8rAEwRTqyiFw4ocn9FnK8E1p7MMQX6WLyiBjO1zsG-S_RR6cZe9YvOGcVo8MVeMdxtD5v9uLWMTsntiDnLa-L9z47TspyXk8WqnC1n_3ifbwBiqg</recordid><startdate>20040812</startdate><enddate>20040812</enddate><creator>Bohling, James</creator><creator>Maikner, John</creator><creator>Kinzey, Marlin</creator><creator>Ziarno, Witold</creator><scope>EFI</scope></search><sort><creationdate>20040812</creationdate><title>Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith</title><author>Bohling, James ; Maikner, John ; Kinzey, Marlin ; Ziarno, Witold</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_applications_200401580373</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2004</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Bohling, James</creatorcontrib><creatorcontrib>Maikner, John</creatorcontrib><creatorcontrib>Kinzey, Marlin</creatorcontrib><creatorcontrib>Ziarno, Witold</creatorcontrib><collection>USPTO Published Applications</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Bohling, James</au><au>Maikner, John</au><au>Kinzey, Marlin</au><au>Ziarno, Witold</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith</title><date>2004-08-12</date><risdate>2004</risdate><abstract>The present invention relates to a process for making a biologically active substance or therapeutic agent free of a chlorotrityl chloride linker-resin. The process includes reacting an activated amino acid or activated amino acid derivative with a substituted or unsubstituted trityl alcohol resin to obtain a resin-CT-AA product; and, reacting the resin-CT-AA product with other building blocks of the biologically active substance or therapeutic agent to obtain said biologically active substance or therapeutic. A product created by this process is also provided herein. The invention is particularly useful to create T-20 and T-1249 therapeutics.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_uspatents_applications_20040158037
source USPTO Published Applications
title Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T00%3A29%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-uspatents_EFI&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Bohling,%20James&rft.date=2004-08-12&rft_id=info:doi/&rft_dat=%3Cuspatents_EFI%3E20040158037%3C/uspatents_EFI%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true