Transgenic cell and animal modeling ige-mediated human allergic responses and use thereof

The invention relates to a transgenic non-human animal cell characterized in that it expresses at least one nucleotide sequence coding for at least one of the chains of human receptors of the fragment F c of IgE immunoglobulins (F c R)) and a nucleotide sequence coding fo a human origin, characterized in that the murine gene coding for the chain F c )R) of the human receptor is inactive. The invention also relates to a corresponding transgenic animal and a method for understanding physiopathological elements involved in immediate hypersensitivity and/or inflammatory mechanisms. The invention further relates to a method for screening active compounds on interactions between human IgE's and the receptors thereof.