System and method for metabolyte neuronal network analysis
The present invention provides a system and method for testing the neuronal effects of a compound and its metabolites. The system ( 100 ) includes a microelectrode array ( 102 ), a data capture unit ( 108 ) communicably coupled to the microelectrode array ( 104 ), a processor ( 110 ) communicably co...
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| creator | Evans, Daron |
| description | The present invention provides a system and method for testing the neuronal effects of a compound and its metabolites. The system (
100
) includes a microelectrode array (
102
), a data capture unit (
108
) communicably coupled to the microelectrode array (
104
), a processor (
110
) communicably coupled to the data capture unit (
108
) and one or more input/output devices (
112
) communicably coupled to the processor (
110
). The microelectrode array (
102
) is capable of supporting genetically modified neuronal cells (
104
) and measuring neuronal activity. The testing medium containing the compound and the metabolites is extracted from hepatocyte cells (
106
). The method (
400
) determines the effects of the metabolites of a sample compound on neuronal cells by exposing a sample compound to hepatocyte cells (
406
), extracting medium from the exposed cells (
408
) and exposing the extracted medium to neuronal cells on a microelectrode array (
410
). The effects of a sample compound and its metabolites versus the effects of a sample compound alone can be determined from a comparison of the data (
406
). |
| format | Patent |
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100
) includes a microelectrode array (
102
), a data capture unit (
108
) communicably coupled to the microelectrode array (
104
), a processor (
110
) communicably coupled to the data capture unit (
108
) and one or more input/output devices (
112
) communicably coupled to the processor (
110
). The microelectrode array (
102
) is capable of supporting genetically modified neuronal cells (
104
) and measuring neuronal activity. The testing medium containing the compound and the metabolites is extracted from hepatocyte cells (
106
). The method (
400
) determines the effects of the metabolites of a sample compound on neuronal cells by exposing a sample compound to hepatocyte cells (
406
), extracting medium from the exposed cells (
408
) and exposing the extracted medium to neuronal cells on a microelectrode array (
410
). The effects of a sample compound and its metabolites versus the effects of a sample compound alone can be determined from a comparison of the data (
406
).</description><language>eng</language><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040106169$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,780,873,885,64059</link.rule.ids><linktorsrc>$$Uhttps://patentcenter.uspto.gov/applications/10371008$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Evans, Daron</creatorcontrib><title>System and method for metabolyte neuronal network analysis</title><description>The present invention provides a system and method for testing the neuronal effects of a compound and its metabolites. The system (
100
) includes a microelectrode array (
102
), a data capture unit (
108
) communicably coupled to the microelectrode array (
104
), a processor (
110
) communicably coupled to the data capture unit (
108
) and one or more input/output devices (
112
) communicably coupled to the processor (
110
). The microelectrode array (
102
) is capable of supporting genetically modified neuronal cells (
104
) and measuring neuronal activity. The testing medium containing the compound and the metabolites is extracted from hepatocyte cells (
106
). The method (
400
) determines the effects of the metabolites of a sample compound on neuronal cells by exposing a sample compound to hepatocyte cells (
406
), extracting medium from the exposed cells (
408
) and exposing the extracted medium to neuronal cells on a microelectrode array (
410
). The effects of a sample compound and its metabolites versus the effects of a sample compound alone can be determined from a comparison of the data (
406
).</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EFI</sourceid><recordid>eNrjZLAKriwuSc1VSMxLUchNLcnIT1FIyy8CMROT8nMqS1IV8lJLi_LzEnOAjJLy_KJsoNLEnMrizGIeBta0xJziVF4ozc2g6eYa4uyhW1pckFiSmldSHJ9YUJCTmZxYkpmfVxxvZGBgYmBoYGZoZmlMiloAP4I2kw</recordid><startdate>20040603</startdate><enddate>20040603</enddate><creator>Evans, Daron</creator><scope>EFI</scope></search><sort><creationdate>20040603</creationdate><title>System and method for metabolyte neuronal network analysis</title><author>Evans, Daron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_applications_200401061693</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2004</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Evans, Daron</creatorcontrib><collection>USPTO Published Applications</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Evans, Daron</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>System and method for metabolyte neuronal network analysis</title><date>2004-06-03</date><risdate>2004</risdate><abstract>The present invention provides a system and method for testing the neuronal effects of a compound and its metabolites. The system (
100
) includes a microelectrode array (
102
), a data capture unit (
108
) communicably coupled to the microelectrode array (
104
), a processor (
110
) communicably coupled to the data capture unit (
108
) and one or more input/output devices (
112
) communicably coupled to the processor (
110
). The microelectrode array (
102
) is capable of supporting genetically modified neuronal cells (
104
) and measuring neuronal activity. The testing medium containing the compound and the metabolites is extracted from hepatocyte cells (
106
). The method (
400
) determines the effects of the metabolites of a sample compound on neuronal cells by exposing a sample compound to hepatocyte cells (
406
), extracting medium from the exposed cells (
408
) and exposing the extracted medium to neuronal cells on a microelectrode array (
410
). The effects of a sample compound and its metabolites versus the effects of a sample compound alone can be determined from a comparison of the data (
406
).</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_uspatents_applications_20040106169 |
| source | USPTO Published Applications |
| title | System and method for metabolyte neuronal network analysis |
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