Synthesis of epothilones, intermediates thereto, analogues and uses thereof

Synthesis of epothilones, intermediates thereto, analogues and uses thereof

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions bas...

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Hauptverfasser: Danishefsky, Samual, Bertinato, Peter, Su, Dai-Shi, Meng, Dang Fang, Chou, Ting-Chao, Kamenecka, Ted, Sorensen, Erik, Balog, Aaron, Savin, Kenneth
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creator Danishefsky, Samual
Bertinato, Peter
Su, Dai-Shi
Meng, Dang Fang
Chou, Ting-Chao
Kamenecka, Ted
Sorensen, Erik
Balog, Aaron
Savin, Kenneth
description The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
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title Synthesis of epothilones, intermediates thereto, analogues and uses thereof
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