Aromatic sulfone hydroxamates and their use as protease inhibitors
This invention is directed to aromatic sulfone hydroxamates (also known as "aromatic sulfone hydroxamic acids") and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. T...
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| creator | Fobian, Y vette Freskos, John Awasthi, Alok Barta, Thomas Becker, Daniel Bedell, Louis Boehm, Terri Carroll, Jeffery Chandrakumar, Nizal DeCrescenzo, Gary Desai, Bipin Heron, Marcia Hockerman, Susan Jull, Sara Kassab, Darren Kolodziej, Steve McDonald, Joseph Mischke, Deborah Mullins, Patrick Norton, Monica Rico, Joseph Talley, John Trivedi, Mahima Villamil, Clara Wang, Lijuan |
| description | This invention is directed to aromatic sulfone hydroxamates (also known as "aromatic sulfone hydroxamic acids") and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity. |
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| title | Aromatic sulfone hydroxamates and their use as protease inhibitors |
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