Porphyron based neuton capture agents for cancer therapy

Porphyron based neuton capture agents for cancer therapy

The invention describes the synthesis of a panel of novel carbon-carbon linked carboranyl-containng 5,10,15,20-tetraphenylporphyrins bearing 25-44% boron by weight. Preliminary in vitro evaluation of several of these compounds, using both rat and human brain tumor cell lines, shows that these compou...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Vicente, M. G. H, Shetty, S.J, Jaquinod, L, Smith, K.M
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Vicente, M. G. H
Shetty, S.J
Jaquinod, L
Smith, K.M
description The invention describes the synthesis of a panel of novel carbon-carbon linked carboranyl-containng 5,10,15,20-tetraphenylporphyrins bearing 25-44% boron by weight. Preliminary in vitro evaluation of several of these compounds, using both rat and human brain tumor cell lines, shows that these compounds display very low cytotoxicities, are capable of delivering substantial amounts of boron intracellularly, and are retained for long periods of time.
format Patent
fullrecord <record><control><sourceid>uspatents_EFI</sourceid><recordid>TN_cdi_uspatents_applications_20040014737</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20040014737</sourcerecordid><originalsourceid>FETCH-uspatents_applications_200400147373</originalsourceid><addsrcrecordid>eNrjZLAIyC8qyKgsys9TSEosTk1RyEstLQFykhMLSkqLUhUS01PzSooV0vKLgEJ5yalFCiUZqUWJBZU8DKxpiTnFqbxQmptB0801xNlDt7S4ILEEpCk-saAgJzM5sSQzP6843sjAwMTAwNDE3NjcmBS1ALN-NZY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Porphyron based neuton capture agents for cancer therapy</title><source>USPTO Published Applications</source><creator>Vicente, M. G. H ; Shetty, S.J ; Jaquinod, L ; Smith, K.M</creator><creatorcontrib>Vicente, M. G. H ; Shetty, S.J ; Jaquinod, L ; Smith, K.M</creatorcontrib><description>The invention describes the synthesis of a panel of novel carbon-carbon linked carboranyl-containng 5,10,15,20-tetraphenylporphyrins bearing 25-44% boron by weight. Preliminary in vitro evaluation of several of these compounds, using both rat and human brain tumor cell lines, shows that these compounds display very low cytotoxicities, are capable of delivering substantial amounts of boron intracellularly, and are retained for long periods of time.</description><language>eng</language><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040014737$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,776,869,881,64032</link.rule.ids><linktorsrc>$$Uhttps://patentcenter.uspto.gov/applications/10258948$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Vicente, M. G. H</creatorcontrib><creatorcontrib>Shetty, S.J</creatorcontrib><creatorcontrib>Jaquinod, L</creatorcontrib><creatorcontrib>Smith, K.M</creatorcontrib><title>Porphyron based neuton capture agents for cancer therapy</title><description>The invention describes the synthesis of a panel of novel carbon-carbon linked carboranyl-containng 5,10,15,20-tetraphenylporphyrins bearing 25-44% boron by weight. Preliminary in vitro evaluation of several of these compounds, using both rat and human brain tumor cell lines, shows that these compounds display very low cytotoxicities, are capable of delivering substantial amounts of boron intracellularly, and are retained for long periods of time.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EFI</sourceid><recordid>eNrjZLAIyC8qyKgsys9TSEosTk1RyEstLQFykhMLSkqLUhUS01PzSooV0vKLgEJ5yalFCiUZqUWJBZU8DKxpiTnFqbxQmptB0801xNlDt7S4ILEEpCk-saAgJzM5sSQzP6843sjAwMTAwNDE3NjcmBS1ALN-NZY</recordid><startdate>20040122</startdate><enddate>20040122</enddate><creator>Vicente, M. G. H</creator><creator>Shetty, S.J</creator><creator>Jaquinod, L</creator><creator>Smith, K.M</creator><scope>EFI</scope></search><sort><creationdate>20040122</creationdate><title>Porphyron based neuton capture agents for cancer therapy</title><author>Vicente, M. G. H ; Shetty, S.J ; Jaquinod, L ; Smith, K.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_applications_200400147373</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2004</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Vicente, M. G. H</creatorcontrib><creatorcontrib>Shetty, S.J</creatorcontrib><creatorcontrib>Jaquinod, L</creatorcontrib><creatorcontrib>Smith, K.M</creatorcontrib><collection>USPTO Published Applications</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Vicente, M. G. H</au><au>Shetty, S.J</au><au>Jaquinod, L</au><au>Smith, K.M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Porphyron based neuton capture agents for cancer therapy</title><date>2004-01-22</date><risdate>2004</risdate><abstract>The invention describes the synthesis of a panel of novel carbon-carbon linked carboranyl-containng 5,10,15,20-tetraphenylporphyrins bearing 25-44% boron by weight. Preliminary in vitro evaluation of several of these compounds, using both rat and human brain tumor cell lines, shows that these compounds display very low cytotoxicities, are capable of delivering substantial amounts of boron intracellularly, and are retained for long periods of time.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_uspatents_applications_20040014737
source USPTO Published Applications
title Porphyron based neuton capture agents for cancer therapy
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T20%3A27%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-uspatents_EFI&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Vicente,%20M.%20G.%20H&rft.date=2004-01-22&rft_id=info:doi/&rft_dat=%3Cuspatents_EFI%3E20040014737%3C/uspatents_EFI%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true