METHODS FOR IDENTIFYING AGENTS THAT INTERACT WITH AN ACTIVE SITE

METHODS FOR IDENTIFYING AGENTS THAT INTERACT WITH AN ACTIVE SITE

This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites...

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Bibliographische Detailangaben
Hauptverfasser: Parris, Kevin, Somers, William, Tam, Amy, Lin, Laura, Stahl, Mark, Powers, Robert, Xu, Guang-Yi
Format: Patent
Sprache:eng
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Zusammenfassung:This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.