Phosphono-carboxylate compounds for treating amyloidosis

Phosphono-carboxylate compounds for treating amyloidosis

Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group,...

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Hauptverfasser: Szarek, Walter, Kong, Xianqi, Thatcher, Gregory, Gorine, Boris
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Sprache:eng
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creator Szarek, Walter
Kong, Xianqi
Thatcher, Gregory
Gorine, Boris
description Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.
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Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.</abstract><oa>free_for_read</oa></addata></record>
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title Phosphono-carboxylate compounds for treating amyloidosis
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