Phenoxazine analogs useful as amyloid aggregation inhibitors and treatment of alzheimer's disease and disorders related to amyloidosis
Disclosed are compounds of the Formula I 1 wherein: R 1 is hydrogen, lower alkyl, or cycloalkyl; R 2 is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, aryl, heteroaryl, arylalkyl, heteroarylalkyl, arylalkoxy, heteroarylalkoxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trif...
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| creator | Lai, Yingjie Augelli-Szafran, Corinne Yasunaga, Tomoyuki |
| description | Disclosed are compounds of the Formula I
1
wherein:
R
1
is hydrogen, lower alkyl, or cycloalkyl;
R
2
is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, aryl, heteroaryl, arylalkyl, heteroarylalkyl, arylalkoxy, heteroarylalkoxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, or mono- or dialkylamino; and
R
3
and R
4
independently are hydrogen, lower alkoxy, aryl, heteroaryl, halogen, hydroxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, mono- or dialkylamino, or unsubstituted or substituted lower alkyl or lower alkenyl; or
R
3
and R
4
together form an unsubstituted or substituted carbocyclic group.
Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits. |
| format | Patent |
| fullrecord | <record><control><sourceid>uspatents_EFI</sourceid><recordid>TN_cdi_uspatents_applications_20020143012</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20020143012</sourcerecordid><originalsourceid>FETCH-uspatents_applications_200201430123</originalsourceid><addsrcrecordid>eNqVjrEKwkAQRNNYiPoP24mFcEn8A1EsLezD6m0uC5fbcHsBzQf43R5BP8BqBubNMMvife0oyBMnDgQY0ItTGJXa0QMqYP_ywhbQuUgOE0sADh3fOUnMcbCQImHqKSSQFtBPHXFPcatgWQmVZih7iZZyJZLHRLkmv3FR1nWxaNErbb66Knbn0-142Y86ZDwkbXAYPD_mC9pUxlSmPNSmrOp_2A8saFNr</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Phenoxazine analogs useful as amyloid aggregation inhibitors and treatment of alzheimer's disease and disorders related to amyloidosis</title><source>USPTO Published Applications</source><creator>Lai, Yingjie ; Augelli-Szafran, Corinne ; Yasunaga, Tomoyuki</creator><creatorcontrib>Lai, Yingjie ; Augelli-Szafran, Corinne ; Yasunaga, Tomoyuki</creatorcontrib><description>Disclosed are compounds of the Formula I
1
wherein:
R
1
is hydrogen, lower alkyl, or cycloalkyl;
R
2
is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, aryl, heteroaryl, arylalkyl, heteroarylalkyl, arylalkoxy, heteroarylalkoxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, or mono- or dialkylamino; and
R
3
and R
4
independently are hydrogen, lower alkoxy, aryl, heteroaryl, halogen, hydroxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, mono- or dialkylamino, or unsubstituted or substituted lower alkyl or lower alkenyl; or
R
3
and R
4
together form an unsubstituted or substituted carbocyclic group.
Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits.</description><language>eng</language><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20020143012$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,780,873,885,64058</link.rule.ids><linktorsrc>$$Uhttps://patentcenter.uspto.gov/applications/09966534$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Lai, Yingjie</creatorcontrib><creatorcontrib>Augelli-Szafran, Corinne</creatorcontrib><creatorcontrib>Yasunaga, Tomoyuki</creatorcontrib><title>Phenoxazine analogs useful as amyloid aggregation inhibitors and treatment of alzheimer's disease and disorders related to amyloidosis</title><description>Disclosed are compounds of the Formula I
1
wherein:
R
1
is hydrogen, lower alkyl, or cycloalkyl;
R
2
is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, aryl, heteroaryl, arylalkyl, heteroarylalkyl, arylalkoxy, heteroarylalkoxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, or mono- or dialkylamino; and
R
3
and R
4
independently are hydrogen, lower alkoxy, aryl, heteroaryl, halogen, hydroxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, mono- or dialkylamino, or unsubstituted or substituted lower alkyl or lower alkenyl; or
R
3
and R
4
together form an unsubstituted or substituted carbocyclic group.
Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EFI</sourceid><recordid>eNqVjrEKwkAQRNNYiPoP24mFcEn8A1EsLezD6m0uC5fbcHsBzQf43R5BP8BqBubNMMvife0oyBMnDgQY0ItTGJXa0QMqYP_ywhbQuUgOE0sADh3fOUnMcbCQImHqKSSQFtBPHXFPcatgWQmVZih7iZZyJZLHRLkmv3FR1nWxaNErbb66Knbn0-142Y86ZDwkbXAYPD_mC9pUxlSmPNSmrOp_2A8saFNr</recordid><startdate>20021003</startdate><enddate>20021003</enddate><creator>Lai, Yingjie</creator><creator>Augelli-Szafran, Corinne</creator><creator>Yasunaga, Tomoyuki</creator><scope>EFI</scope></search><sort><creationdate>20021003</creationdate><title>Phenoxazine analogs useful as amyloid aggregation inhibitors and treatment of alzheimer's disease and disorders related to amyloidosis</title><author>Lai, Yingjie ; Augelli-Szafran, Corinne ; Yasunaga, Tomoyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_applications_200201430123</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2002</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Lai, Yingjie</creatorcontrib><creatorcontrib>Augelli-Szafran, Corinne</creatorcontrib><creatorcontrib>Yasunaga, Tomoyuki</creatorcontrib><collection>USPTO Published Applications</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lai, Yingjie</au><au>Augelli-Szafran, Corinne</au><au>Yasunaga, Tomoyuki</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Phenoxazine analogs useful as amyloid aggregation inhibitors and treatment of alzheimer's disease and disorders related to amyloidosis</title><date>2002-10-03</date><risdate>2002</risdate><abstract>Disclosed are compounds of the Formula I
1
wherein:
R
1
is hydrogen, lower alkyl, or cycloalkyl;
R
2
is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, aryl, heteroaryl, arylalkyl, heteroarylalkyl, arylalkoxy, heteroarylalkoxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, or mono- or dialkylamino; and
R
3
and R
4
independently are hydrogen, lower alkoxy, aryl, heteroaryl, halogen, hydroxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, mono- or dialkylamino, or unsubstituted or substituted lower alkyl or lower alkenyl; or
R
3
and R
4
together form an unsubstituted or substituted carbocyclic group.
Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | USPTO Published Applications |
| title | Phenoxazine analogs useful as amyloid aggregation inhibitors and treatment of alzheimer's disease and disorders related to amyloidosis |
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