Meta-analysis identifies seven susceptibility loci involved in the atopic march
Eczema often precedes the development of asthma in a disease course called the ‘atopic march’. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations in...
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| creator | Marenholz, Ingo Esparza-Gordillo, Jorge Rüschendorf, Franz Bauerfeind, Anja Strachan, David P Spycher, Ben D Baurecht, Hansjörg Margaritte-Jeannin, Patricia Sääf, Annika Kerkhof, Marjan Ege, Markus Baltic, Svetlana Matheson, Melanie C Li, Jin Michel, Sven Ang, Wei Q McArdle, Wendy Arnold, Andreas Homuth, Georg Demenais, Florence Bouzigon, Emmanuelle Söderhäll, Cilla Pershagen, Göran de Jongste, Johan C Postma, Dirkje S Braun-Fahrländer, Charlotte Horak, Elisabeth Ogorodova, Ludmila M Puzyrev, Valery P Bragina, Elena Yu Hudson, Thomas J Morin, Charles Duffy, David L Marks, Guy B Robertson, Colin F Montgomery, Grant W Musk, Bill Thompson, Philip J Martin, Nicholas G James, Alan Sleiman, Patrick Toskala, Elina Rodriguez, Elke Fölster-Holst, Regina Franke, Andre Lieb, Wolfgang Gieger, Christian Heinzmann, Andrea Rietschel, Ernst Keil, Thomas Cichon, Sven Nöthen, Markus M Pennell, Craig E Sly, Peter D Schmidt, Carsten O Matanovic, Anja Schneider, Valentin Heinig, Matthias Hübner, Norbert Holt, Patrick G Lau, Susanne Kabesch, Michael Weidinger, Stefan Hakonarson, Hakon Ferreira, Manuel A. R Laprise, Catherine Freidin, Maxim B Genuneit, Jon Koppelman, Gerard H Melén, Erik Dizier, Marie- Hélène Henderson, A John Lee, Young Ae |
| description | Eczema often precedes the development of asthma in a disease course called the ‘atopic march’. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10−8) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10−9). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema. |
| doi_str_mv | 10.1038/ncomms9804 |
| format | Article |
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Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. 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R</creatorcontrib><creatorcontrib>Laprise, Catherine</creatorcontrib><creatorcontrib>Freidin, Maxim B</creatorcontrib><creatorcontrib>Genuneit, Jon</creatorcontrib><creatorcontrib>Koppelman, Gerard H</creatorcontrib><creatorcontrib>Melén, Erik</creatorcontrib><creatorcontrib>Dizier, Marie- Hélène</creatorcontrib><creatorcontrib>Henderson, A John</creatorcontrib><creatorcontrib>Lee, Young Ae</creatorcontrib><title>Meta-analysis identifies seven susceptibility loci involved in the atopic march</title><description>Eczema often precedes the development of asthma in a disease course called the ‘atopic march’. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10−8) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10−9). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.</description><subject>allergic disease</subject><subject>asthma</subject><subject>atopic march</subject><subject>Biologie moléculaire</subject><subject>eczema</subject><subject>genetics</subject><subject>Génétique</subject><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>QYEPL</sourceid><recordid>eNqlizEKwkAQRbexELXxBHOBaOJaxFoUG7GxD-M6IQObnehMArm9gla2Vv_xeN-5ZZGvityX6xSkbXVX5tupu5zJMMOEcVRW4Dsl45pJQWmgBNproM74xpFthCiBgdMgcaD7G8AaAjTpOECLz9DM3aTGqLT47syVx8N1f8r6B4YqSFKjGNFYUiXIP-YTYeU3hfd_XF8aX1J5</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Marenholz, Ingo</creator><creator>Esparza-Gordillo, Jorge</creator><creator>Rüschendorf, Franz</creator><creator>Bauerfeind, Anja</creator><creator>Strachan, David P</creator><creator>Spycher, Ben D</creator><creator>Baurecht, Hansjörg</creator><creator>Margaritte-Jeannin, Patricia</creator><creator>Sääf, Annika</creator><creator>Kerkhof, Marjan</creator><creator>Ege, Markus</creator><creator>Baltic, Svetlana</creator><creator>Matheson, Melanie C</creator><creator>Li, Jin</creator><creator>Michel, Sven</creator><creator>Ang, Wei Q</creator><creator>McArdle, Wendy</creator><creator>Arnold, Andreas</creator><creator>Homuth, Georg</creator><creator>Demenais, Florence</creator><creator>Bouzigon, Emmanuelle</creator><creator>Söderhäll, Cilla</creator><creator>Pershagen, Göran</creator><creator>de Jongste, Johan C</creator><creator>Postma, Dirkje S</creator><creator>Braun-Fahrländer, Charlotte</creator><creator>Horak, Elisabeth</creator><creator>Ogorodova, Ludmila M</creator><creator>Puzyrev, Valery P</creator><creator>Bragina, Elena Yu</creator><creator>Hudson, Thomas J</creator><creator>Morin, Charles</creator><creator>Duffy, David L</creator><creator>Marks, Guy B</creator><creator>Robertson, Colin F</creator><creator>Montgomery, Grant W</creator><creator>Musk, Bill</creator><creator>Thompson, Philip J</creator><creator>Martin, Nicholas G</creator><creator>James, Alan</creator><creator>Sleiman, Patrick</creator><creator>Toskala, Elina</creator><creator>Rodriguez, Elke</creator><creator>Fölster-Holst, Regina</creator><creator>Franke, Andre</creator><creator>Lieb, Wolfgang</creator><creator>Gieger, Christian</creator><creator>Heinzmann, Andrea</creator><creator>Rietschel, Ernst</creator><creator>Keil, Thomas</creator><creator>Cichon, Sven</creator><creator>Nöthen, Markus M</creator><creator>Pennell, Craig E</creator><creator>Sly, Peter D</creator><creator>Schmidt, Carsten O</creator><creator>Matanovic, Anja</creator><creator>Schneider, Valentin</creator><creator>Heinig, Matthias</creator><creator>Hübner, Norbert</creator><creator>Holt, Patrick G</creator><creator>Lau, Susanne</creator><creator>Kabesch, Michael</creator><creator>Weidinger, Stefan</creator><creator>Hakonarson, Hakon</creator><creator>Ferreira, Manuel A. 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R ; Laprise, Catherine ; Freidin, Maxim B ; Genuneit, Jon ; Koppelman, Gerard H ; Melén, Erik ; Dizier, Marie- Hélène ; Henderson, A John ; Lee, Young Ae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uqac_constellation_oai_constellation_uqac_ca_32133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>allergic disease</topic><topic>asthma</topic><topic>atopic march</topic><topic>Biologie moléculaire</topic><topic>eczema</topic><topic>genetics</topic><topic>Génétique</topic><toplevel>online_resources</toplevel><creatorcontrib>Marenholz, Ingo</creatorcontrib><creatorcontrib>Esparza-Gordillo, Jorge</creatorcontrib><creatorcontrib>Rüschendorf, Franz</creatorcontrib><creatorcontrib>Bauerfeind, Anja</creatorcontrib><creatorcontrib>Strachan, David P</creatorcontrib><creatorcontrib>Spycher, Ben D</creatorcontrib><creatorcontrib>Baurecht, Hansjörg</creatorcontrib><creatorcontrib>Margaritte-Jeannin, Patricia</creatorcontrib><creatorcontrib>Sääf, Annika</creatorcontrib><creatorcontrib>Kerkhof, Marjan</creatorcontrib><creatorcontrib>Ege, Markus</creatorcontrib><creatorcontrib>Baltic, Svetlana</creatorcontrib><creatorcontrib>Matheson, Melanie C</creatorcontrib><creatorcontrib>Li, Jin</creatorcontrib><creatorcontrib>Michel, Sven</creatorcontrib><creatorcontrib>Ang, Wei Q</creatorcontrib><creatorcontrib>McArdle, Wendy</creatorcontrib><creatorcontrib>Arnold, Andreas</creatorcontrib><creatorcontrib>Homuth, Georg</creatorcontrib><creatorcontrib>Demenais, Florence</creatorcontrib><creatorcontrib>Bouzigon, Emmanuelle</creatorcontrib><creatorcontrib>Söderhäll, Cilla</creatorcontrib><creatorcontrib>Pershagen, Göran</creatorcontrib><creatorcontrib>de Jongste, Johan C</creatorcontrib><creatorcontrib>Postma, Dirkje S</creatorcontrib><creatorcontrib>Braun-Fahrländer, Charlotte</creatorcontrib><creatorcontrib>Horak, Elisabeth</creatorcontrib><creatorcontrib>Ogorodova, Ludmila M</creatorcontrib><creatorcontrib>Puzyrev, Valery P</creatorcontrib><creatorcontrib>Bragina, Elena Yu</creatorcontrib><creatorcontrib>Hudson, Thomas J</creatorcontrib><creatorcontrib>Morin, Charles</creatorcontrib><creatorcontrib>Duffy, David L</creatorcontrib><creatorcontrib>Marks, Guy B</creatorcontrib><creatorcontrib>Robertson, Colin F</creatorcontrib><creatorcontrib>Montgomery, Grant W</creatorcontrib><creatorcontrib>Musk, Bill</creatorcontrib><creatorcontrib>Thompson, Philip J</creatorcontrib><creatorcontrib>Martin, Nicholas G</creatorcontrib><creatorcontrib>James, Alan</creatorcontrib><creatorcontrib>Sleiman, Patrick</creatorcontrib><creatorcontrib>Toskala, Elina</creatorcontrib><creatorcontrib>Rodriguez, Elke</creatorcontrib><creatorcontrib>Fölster-Holst, Regina</creatorcontrib><creatorcontrib>Franke, Andre</creatorcontrib><creatorcontrib>Lieb, Wolfgang</creatorcontrib><creatorcontrib>Gieger, Christian</creatorcontrib><creatorcontrib>Heinzmann, Andrea</creatorcontrib><creatorcontrib>Rietschel, Ernst</creatorcontrib><creatorcontrib>Keil, Thomas</creatorcontrib><creatorcontrib>Cichon, Sven</creatorcontrib><creatorcontrib>Nöthen, Markus M</creatorcontrib><creatorcontrib>Pennell, Craig E</creatorcontrib><creatorcontrib>Sly, Peter D</creatorcontrib><creatorcontrib>Schmidt, Carsten O</creatorcontrib><creatorcontrib>Matanovic, Anja</creatorcontrib><creatorcontrib>Schneider, Valentin</creatorcontrib><creatorcontrib>Heinig, Matthias</creatorcontrib><creatorcontrib>Hübner, Norbert</creatorcontrib><creatorcontrib>Holt, Patrick G</creatorcontrib><creatorcontrib>Lau, Susanne</creatorcontrib><creatorcontrib>Kabesch, Michael</creatorcontrib><creatorcontrib>Weidinger, Stefan</creatorcontrib><creatorcontrib>Hakonarson, Hakon</creatorcontrib><creatorcontrib>Ferreira, Manuel A. R</creatorcontrib><creatorcontrib>Laprise, Catherine</creatorcontrib><creatorcontrib>Freidin, Maxim B</creatorcontrib><creatorcontrib>Genuneit, Jon</creatorcontrib><creatorcontrib>Koppelman, Gerard H</creatorcontrib><creatorcontrib>Melén, Erik</creatorcontrib><creatorcontrib>Dizier, Marie- Hélène</creatorcontrib><creatorcontrib>Henderson, A John</creatorcontrib><creatorcontrib>Lee, Young Ae</creatorcontrib><collection>Constellation (Université du Québec à Chicoutimi)</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Marenholz, Ingo</au><au>Esparza-Gordillo, Jorge</au><au>Rüschendorf, Franz</au><au>Bauerfeind, Anja</au><au>Strachan, David P</au><au>Spycher, Ben D</au><au>Baurecht, Hansjörg</au><au>Margaritte-Jeannin, Patricia</au><au>Sääf, Annika</au><au>Kerkhof, Marjan</au><au>Ege, Markus</au><au>Baltic, Svetlana</au><au>Matheson, Melanie C</au><au>Li, Jin</au><au>Michel, Sven</au><au>Ang, Wei Q</au><au>McArdle, Wendy</au><au>Arnold, Andreas</au><au>Homuth, Georg</au><au>Demenais, Florence</au><au>Bouzigon, Emmanuelle</au><au>Söderhäll, Cilla</au><au>Pershagen, Göran</au><au>de Jongste, Johan C</au><au>Postma, Dirkje S</au><au>Braun-Fahrländer, Charlotte</au><au>Horak, Elisabeth</au><au>Ogorodova, Ludmila M</au><au>Puzyrev, Valery P</au><au>Bragina, Elena Yu</au><au>Hudson, Thomas J</au><au>Morin, Charles</au><au>Duffy, David L</au><au>Marks, Guy B</au><au>Robertson, Colin F</au><au>Montgomery, Grant W</au><au>Musk, Bill</au><au>Thompson, Philip J</au><au>Martin, Nicholas G</au><au>James, Alan</au><au>Sleiman, Patrick</au><au>Toskala, Elina</au><au>Rodriguez, Elke</au><au>Fölster-Holst, Regina</au><au>Franke, Andre</au><au>Lieb, Wolfgang</au><au>Gieger, Christian</au><au>Heinzmann, Andrea</au><au>Rietschel, Ernst</au><au>Keil, Thomas</au><au>Cichon, Sven</au><au>Nöthen, Markus M</au><au>Pennell, Craig E</au><au>Sly, Peter D</au><au>Schmidt, Carsten O</au><au>Matanovic, Anja</au><au>Schneider, Valentin</au><au>Heinig, Matthias</au><au>Hübner, Norbert</au><au>Holt, Patrick G</au><au>Lau, Susanne</au><au>Kabesch, Michael</au><au>Weidinger, Stefan</au><au>Hakonarson, Hakon</au><au>Ferreira, Manuel A. R</au><au>Laprise, Catherine</au><au>Freidin, Maxim B</au><au>Genuneit, Jon</au><au>Koppelman, Gerard H</au><au>Melén, Erik</au><au>Dizier, Marie- Hélène</au><au>Henderson, A John</au><au>Lee, Young Ae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis identifies seven susceptibility loci involved in the atopic march</atitle><date>2015-11</date><risdate>2015</risdate><abstract>Eczema often precedes the development of asthma in a disease course called the ‘atopic march’. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10−8) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10−9). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.</abstract><doi>10.1038/ncomms9804</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | DOI: 10.1038/ncomms9804 |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_uqac_constellation_oai_constellation_uqac_ca_3213 |
| source | Constellation (Université du Québec à Chicoutimi) |
| subjects | allergic disease asthma atopic march Biologie moléculaire eczema genetics Génétique |
| title | Meta-analysis identifies seven susceptibility loci involved in the atopic march |
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