Does folinic acid have a choleretic effect on humans?
The aim of this study was to clarify whether folinic acid has any choleretic effect in humans, as observed by Kajiyama et al. in both clinical and experimental studies. The choleretic effect of folinic acid was analyzed prospectively in a subgroup of patients who had external biliary catheters with...
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| Veröffentlicht in: | The Turkish journal of gastroenterology 2003-06, Vol.14 (2), p.102-105 |
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| container_title | The Turkish journal of gastroenterology |
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| creator | Karakayali, Feza Y Bayar, Sancar Hazinedaroğlu, Selçuk Sahin, Fevzi Karayalçin, Kaan |
| description | The aim of this study was to clarify whether folinic acid has any choleretic effect in humans, as observed by Kajiyama et al. in both clinical and experimental studies.
The choleretic effect of folinic acid was analyzed prospectively in a subgroup of patients who had external biliary catheters with periampullary tumors causing complete biliary obstruction. Folinic acid (50mg/day) was administered twice with a 24-hour interval between each dose. Daily bile volume was then recorded on the three consecutive days following the first dose of folinic acid. Mean bile flows (basal output=mean bile volume of four days) before and after (fifth, sixth and seventh days) the initiation of folinic acid administration were then compared.
Mean bile volumes were determined as baseline output: 669.20+/-235.18, 5th day=: 668.63+/-235.26, sixth day: 670.45+/-235.08, and seventh day: 670.00+/-235.11. No significant difference in daily bile volumes before and after folinic acid administration was detected (p>0.05).
No choleretic effect of intravenous folinic acid administration was observed in this prospective clinical study. This finding was contrary to our previous study on this subject. |
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The choleretic effect of folinic acid was analyzed prospectively in a subgroup of patients who had external biliary catheters with periampullary tumors causing complete biliary obstruction. Folinic acid (50mg/day) was administered twice with a 24-hour interval between each dose. Daily bile volume was then recorded on the three consecutive days following the first dose of folinic acid. Mean bile flows (basal output=mean bile volume of four days) before and after (fifth, sixth and seventh days) the initiation of folinic acid administration were then compared.
Mean bile volumes were determined as baseline output: 669.20+/-235.18, 5th day=: 668.63+/-235.26, sixth day: 670.45+/-235.08, and seventh day: 670.00+/-235.11. No significant difference in daily bile volumes before and after folinic acid administration was detected (p>0.05).
No choleretic effect of intravenous folinic acid administration was observed in this prospective clinical study. This finding was contrary to our previous study on this subject.</description><identifier>ISSN: 1300-4948</identifier><identifier>PMID: 14614635</identifier><language>eng</language><publisher>Turkey: Türk Gastroenteroloji Vakfı</publisher><subject>Adult ; Aged ; Araştırma teknikleri ; Bile ; Biliary Tract Neoplasms - drug therapy ; Cholagogues and Choleretics ; Cholagogues and Choleretics - pharmacology ; Drainage ; Female ; Fluids and secretions ; Hematologic, gastrointestinal and renal agents ; Hematolojik, gastrointestinal ve renal ajanlar ; Humans ; Investigative Techniques ; Kolagoglar ve koleretikler ; Leucovorin ; Leucovorin - pharmacology ; Lökovorin ; Male ; Middle Aged ; Prospective Studies ; Safra ; Sıvılar ve salgılar</subject><ispartof>The Turkish journal of gastroenterology, 2003-06, Vol.14 (2), p.102-105</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14614635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karakayali, Feza Y</creatorcontrib><creatorcontrib>Bayar, Sancar</creatorcontrib><creatorcontrib>Hazinedaroğlu, Selçuk</creatorcontrib><creatorcontrib>Sahin, Fevzi</creatorcontrib><creatorcontrib>Karayalçin, Kaan</creatorcontrib><title>Does folinic acid have a choleretic effect on humans?</title><title>The Turkish journal of gastroenterology</title><addtitle>Turk J Gastroenterol</addtitle><description>The aim of this study was to clarify whether folinic acid has any choleretic effect in humans, as observed by Kajiyama et al. in both clinical and experimental studies.
The choleretic effect of folinic acid was analyzed prospectively in a subgroup of patients who had external biliary catheters with periampullary tumors causing complete biliary obstruction. Folinic acid (50mg/day) was administered twice with a 24-hour interval between each dose. Daily bile volume was then recorded on the three consecutive days following the first dose of folinic acid. Mean bile flows (basal output=mean bile volume of four days) before and after (fifth, sixth and seventh days) the initiation of folinic acid administration were then compared.
Mean bile volumes were determined as baseline output: 669.20+/-235.18, 5th day=: 668.63+/-235.26, sixth day: 670.45+/-235.08, and seventh day: 670.00+/-235.11. No significant difference in daily bile volumes before and after folinic acid administration was detected (p>0.05).
No choleretic effect of intravenous folinic acid administration was observed in this prospective clinical study. This finding was contrary to our previous study on this subject.</description><subject>Adult</subject><subject>Aged</subject><subject>Araştırma teknikleri</subject><subject>Bile</subject><subject>Biliary Tract Neoplasms - drug therapy</subject><subject>Cholagogues and Choleretics</subject><subject>Cholagogues and Choleretics - pharmacology</subject><subject>Drainage</subject><subject>Female</subject><subject>Fluids and secretions</subject><subject>Hematologic, gastrointestinal and renal agents</subject><subject>Hematolojik, gastrointestinal ve renal ajanlar</subject><subject>Humans</subject><subject>Investigative Techniques</subject><subject>Kolagoglar ve koleretikler</subject><subject>Leucovorin</subject><subject>Leucovorin - pharmacology</subject><subject>Lökovorin</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Safra</subject><subject>Sıvılar ve salgılar</subject><issn>1300-4948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAcxHNQ3HX1G4jk5K2QV_M4iaxPWPCi55Kk_7DRtKlNK_jtLewqDAzMDL_DnKA15YRUwgi9QuelfBDCNZXsDK2okIt4vUb1fYaCQ06xjx5bH1u8t9-ALfb7nGCEaYkhBPATzj3ez53ty-0FOg02Fbg8-ga9Pz68bZ-r3evTy_ZuVw1UcFpJYbX0mtnAW0Op48QFZmrFa6q0tIZ6rZXiRBAPzMs2BCmolNI4ZwhbEBt0deDOyX662DXDGDs7_jSMM0GX-uZQD2P-mqFMTReLh5RsD3kujaJc1ZLpZXh9HM6ug_Yf8_cD_wXtYVTi</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Karakayali, Feza Y</creator><creator>Bayar, Sancar</creator><creator>Hazinedaroğlu, Selçuk</creator><creator>Sahin, Fevzi</creator><creator>Karayalçin, Kaan</creator><general>Türk Gastroenteroloji Vakfı</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>GIY</scope><scope>GIZ</scope><scope>GJA</scope><scope>GJB</scope></search><sort><creationdate>200306</creationdate><title>Does folinic acid have a choleretic effect on humans?</title><author>Karakayali, Feza Y ; Bayar, Sancar ; Hazinedaroğlu, Selçuk ; Sahin, Fevzi ; Karayalçin, Kaan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1431-64a86c82af3d911b30bf2957351786a91c88773040ce2c6dff6416669bb902143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Araştırma teknikleri</topic><topic>Bile</topic><topic>Biliary Tract Neoplasms - drug therapy</topic><topic>Cholagogues and Choleretics</topic><topic>Cholagogues and Choleretics - pharmacology</topic><topic>Drainage</topic><topic>Female</topic><topic>Fluids and secretions</topic><topic>Hematologic, gastrointestinal and renal agents</topic><topic>Hematolojik, gastrointestinal ve renal ajanlar</topic><topic>Humans</topic><topic>Investigative Techniques</topic><topic>Kolagoglar ve koleretikler</topic><topic>Leucovorin</topic><topic>Leucovorin - pharmacology</topic><topic>Lökovorin</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Safra</topic><topic>Sıvılar ve salgılar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karakayali, Feza Y</creatorcontrib><creatorcontrib>Bayar, Sancar</creatorcontrib><creatorcontrib>Hazinedaroğlu, Selçuk</creatorcontrib><creatorcontrib>Sahin, Fevzi</creatorcontrib><creatorcontrib>Karayalçin, Kaan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>ULAKBIM - Mühendislik ve Temel Bilimler Veri Tabani</collection><collection>ULAKBIM - Yaşam Bilimleri Veri Tabani</collection><collection>ULAKBIM - Turk Sosyal Bilimler Veri Tabani</collection><collection>ULAKBIM - Türk Tıp Veri Tabani</collection><jtitle>The Turkish journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karakayali, Feza Y</au><au>Bayar, Sancar</au><au>Hazinedaroğlu, Selçuk</au><au>Sahin, Fevzi</au><au>Karayalçin, Kaan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does folinic acid have a choleretic effect on humans?</atitle><jtitle>The Turkish journal of gastroenterology</jtitle><addtitle>Turk J Gastroenterol</addtitle><date>2003-06</date><risdate>2003</risdate><volume>14</volume><issue>2</issue><spage>102</spage><epage>105</epage><pages>102-105</pages><issn>1300-4948</issn><abstract>The aim of this study was to clarify whether folinic acid has any choleretic effect in humans, as observed by Kajiyama et al. in both clinical and experimental studies.
The choleretic effect of folinic acid was analyzed prospectively in a subgroup of patients who had external biliary catheters with periampullary tumors causing complete biliary obstruction. Folinic acid (50mg/day) was administered twice with a 24-hour interval between each dose. Daily bile volume was then recorded on the three consecutive days following the first dose of folinic acid. Mean bile flows (basal output=mean bile volume of four days) before and after (fifth, sixth and seventh days) the initiation of folinic acid administration were then compared.
Mean bile volumes were determined as baseline output: 669.20+/-235.18, 5th day=: 668.63+/-235.26, sixth day: 670.45+/-235.08, and seventh day: 670.00+/-235.11. No significant difference in daily bile volumes before and after folinic acid administration was detected (p>0.05).
No choleretic effect of intravenous folinic acid administration was observed in this prospective clinical study. This finding was contrary to our previous study on this subject.</abstract><cop>Turkey</cop><pub>Türk Gastroenteroloji Vakfı</pub><pmid>14614635</pmid><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Araştırma teknikleri Bile Biliary Tract Neoplasms - drug therapy Cholagogues and Choleretics Cholagogues and Choleretics - pharmacology Drainage Female Fluids and secretions Hematologic, gastrointestinal and renal agents Hematolojik, gastrointestinal ve renal ajanlar Humans Investigative Techniques Kolagoglar ve koleretikler Leucovorin Leucovorin - pharmacology Lökovorin Male Middle Aged Prospective Studies Safra Sıvılar ve salgılar |
| title | Does folinic acid have a choleretic effect on humans? |
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