Akut lösemi ve aplastik anemide HLA-DRB alelleri
II. Sınıf HLA antijenleri (HLA-DR) ile aplastik anemi (AA), akut tenfoblastik lösemi (ALL) ve akut myeloid lösemi (AML) ilişkisi çeşitli çalışmalarda gösterilmiştir. Bu çalışmada, DRB aletleri 187 hasta (33 AA, 60AML, 94 ALL) ve 75 kontrol de PCR-SSP yöntemi ile araştırıldı. AA'lı hastalarda DR...
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| Veröffentlicht in: | Gülhane tıp dergisi 2001, Vol.43 (3), p.312-315 |
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| creator | AYNA, Tülay SEYHUN, Yalçın BEŞIŞIK, Sevgi, Kalayoğlu KEKİK, Çiğdem BİLGEN, Hülya ANAK, Sema YALMAN, Nevin SARGIN, Deniz ÇARİN, Mahmut OĞUZ, Fatma, Savran DİLER, A. Sarper GEDİKOĞLU, Gündüz |
| description | II. Sınıf HLA antijenleri (HLA-DR) ile aplastik anemi (AA), akut tenfoblastik lösemi (ALL) ve akut myeloid lösemi (AML) ilişkisi çeşitli çalışmalarda gösterilmiştir. Bu çalışmada, DRB aletleri 187 hasta (33 AA, 60AML, 94 ALL) ve 75 kontrol de PCR-SSP yöntemi ile araştırıldı. AA'lı hastalarda DRB1*15 a/e// ile pozitif (p=0.03 OR= 3.4), DRB1*13 aleli ile negatif ilişki (p=0.03, OR=0.13) olduğu gözlendi. AML'Iİ hastalarda ise DRB1*15 ve DRB1*11 aletleri ile pozitif bir ilişki saptandı (p=0.001,OR=3.6, p=0.003 OR=3). ALL'li hastalarda DRB1*14 sıklığı kontrole göre anlamlı olarak düşük bulundu (p=0.006, OR=0.14). AML'Iİ hastalarda DRB5 ve DRB4 aletleri, AA'lı hastalarda DRB5 aleli kontrole göre anlamlı olarak yüksek bulundu (p=0.0002, p=0.005), (p=0.005). Bu aletler ile hastalıklar arasındaki pozitif ilişkinin gösterilmesi, bazı DR aletlerinin akut lösemiler ve aplastik anemi için artmış bir yatkınlık oluşturabileceği sonucu ileri sürülebilir.
Many studies have revealed the relationship of HLA Class II (HLA DR) antigens with aplastic anemia (AA), acute lymphoblastic leukemia (ALL), and acute myeloblastic leukemia (AML). We used the PCR-SSP method on 187 patients (AA: 33, ALL: 94, AML: 60) and 75 control subjects. We found AA to be positively related with DRB1*15 allele (p=0.03, OR= 3.4) and negatively with DRB1*13 (p=0.03, OR=0.13). AML was positively correlated with DRB1*15 and DRB1*11 (p=0.001, OR-3.6, p=0.003, OR=3). The DRB1*14 allele frequency was found to be significantly decreased in the ALL group with respect to the controls (p=0.006, OR-0.14). Increased frequency of DRB5 and DRB4 was observed in the AML group (p= 0.002, p-0.005), whereas only DRB5 enhancement was present in the AA group (p=0.005). The positive correlation found between these alleles and the disease may suggest the susceptibility between several DR a/fetes, acute leukemia and aplastic anemia. |
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Many studies have revealed the relationship of HLA Class II (HLA DR) antigens with aplastic anemia (AA), acute lymphoblastic leukemia (ALL), and acute myeloblastic leukemia (AML). We used the PCR-SSP method on 187 patients (AA: 33, ALL: 94, AML: 60) and 75 control subjects. We found AA to be positively related with DRB1*15 allele (p=0.03, OR= 3.4) and negatively with DRB1*13 (p=0.03, OR=0.13). AML was positively correlated with DRB1*15 and DRB1*11 (p=0.001, OR-3.6, p=0.003, OR=3). The DRB1*14 allele frequency was found to be significantly decreased in the ALL group with respect to the controls (p=0.006, OR-0.14). Increased frequency of DRB5 and DRB4 was observed in the AML group (p= 0.002, p-0.005), whereas only DRB5 enhancement was present in the AA group (p=0.005). The positive correlation found between these alleles and the disease may suggest the susceptibility between several DR a/fetes, acute leukemia and aplastic anemia.</description><identifier>ISSN: 1302-0471</identifier><language>tur</language><publisher>Gülhane Askeri Tıp Akademisi</publisher><subject>Alleles ; Anemi ; Anemia ; Gen çiftleri ; Genetic processes ; Genetik oluşumlar ; Hemic and lymphatic diseases ; Hemik ve lenfatik hastalıklar ; HLA-D Antigens ; HLA-D antijenleri ; Immunologic and biological factors ; İmmünolojik ve biyolojik faktörler ; Leukemia, Lymphocytic, Acute ; Leukemia, Myelocytic, Acute ; Lösemi, lenfositik, akut ; Lösemi, miyelositik, akut ; Neoplasms ; Neoplazmlar ; Polimeraz zincir reaksiyonu ; Polymerase Chain Reaction</subject><ispartof>Gülhane tıp dergisi, 2001, Vol.43 (3), p.312-315</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids></links><search><creatorcontrib>AYNA, Tülay</creatorcontrib><creatorcontrib>SEYHUN, Yalçın</creatorcontrib><creatorcontrib>BEŞIŞIK, Sevgi, Kalayoğlu</creatorcontrib><creatorcontrib>KEKİK, Çiğdem</creatorcontrib><creatorcontrib>BİLGEN, Hülya</creatorcontrib><creatorcontrib>ANAK, Sema</creatorcontrib><creatorcontrib>YALMAN, Nevin</creatorcontrib><creatorcontrib>SARGIN, Deniz</creatorcontrib><creatorcontrib>ÇARİN, Mahmut</creatorcontrib><creatorcontrib>OĞUZ, Fatma, Savran</creatorcontrib><creatorcontrib>DİLER, A. Sarper</creatorcontrib><creatorcontrib>GEDİKOĞLU, Gündüz</creatorcontrib><title>Akut lösemi ve aplastik anemide HLA-DRB alelleri</title><title>Gülhane tıp dergisi</title><description>II. Sınıf HLA antijenleri (HLA-DR) ile aplastik anemi (AA), akut tenfoblastik lösemi (ALL) ve akut myeloid lösemi (AML) ilişkisi çeşitli çalışmalarda gösterilmiştir. Bu çalışmada, DRB aletleri 187 hasta (33 AA, 60AML, 94 ALL) ve 75 kontrol de PCR-SSP yöntemi ile araştırıldı. AA'lı hastalarda DRB1*15 a/e// ile pozitif (p=0.03 OR= 3.4), DRB1*13 aleli ile negatif ilişki (p=0.03, OR=0.13) olduğu gözlendi. AML'Iİ hastalarda ise DRB1*15 ve DRB1*11 aletleri ile pozitif bir ilişki saptandı (p=0.001,OR=3.6, p=0.003 OR=3). ALL'li hastalarda DRB1*14 sıklığı kontrole göre anlamlı olarak düşük bulundu (p=0.006, OR=0.14). AML'Iİ hastalarda DRB5 ve DRB4 aletleri, AA'lı hastalarda DRB5 aleli kontrole göre anlamlı olarak yüksek bulundu (p=0.0002, p=0.005), (p=0.005). Bu aletler ile hastalıklar arasındaki pozitif ilişkinin gösterilmesi, bazı DR aletlerinin akut lösemiler ve aplastik anemi için artmış bir yatkınlık oluşturabileceği sonucu ileri sürülebilir.
Many studies have revealed the relationship of HLA Class II (HLA DR) antigens with aplastic anemia (AA), acute lymphoblastic leukemia (ALL), and acute myeloblastic leukemia (AML). We used the PCR-SSP method on 187 patients (AA: 33, ALL: 94, AML: 60) and 75 control subjects. We found AA to be positively related with DRB1*15 allele (p=0.03, OR= 3.4) and negatively with DRB1*13 (p=0.03, OR=0.13). AML was positively correlated with DRB1*15 and DRB1*11 (p=0.001, OR-3.6, p=0.003, OR=3). The DRB1*14 allele frequency was found to be significantly decreased in the ALL group with respect to the controls (p=0.006, OR-0.14). Increased frequency of DRB5 and DRB4 was observed in the AML group (p= 0.002, p-0.005), whereas only DRB5 enhancement was present in the AA group (p=0.005). The positive correlation found between these alleles and the disease may suggest the susceptibility between several DR a/fetes, acute leukemia and aplastic anemia.</description><subject>Alleles</subject><subject>Anemi</subject><subject>Anemia</subject><subject>Gen çiftleri</subject><subject>Genetic processes</subject><subject>Genetik oluşumlar</subject><subject>Hemic and lymphatic diseases</subject><subject>Hemik ve lenfatik hastalıklar</subject><subject>HLA-D Antigens</subject><subject>HLA-D antijenleri</subject><subject>Immunologic and biological factors</subject><subject>İmmünolojik ve biyolojik faktörler</subject><subject>Leukemia, Lymphocytic, Acute</subject><subject>Leukemia, Myelocytic, Acute</subject><subject>Lösemi, lenfositik, akut</subject><subject>Lösemi, miyelositik, akut</subject><subject>Neoplasms</subject><subject>Neoplazmlar</subject><subject>Polimeraz zincir reaksiyonu</subject><subject>Polymerase Chain Reaction</subject><issn>1302-0471</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNpjYeA0NDYw0jUwMTfkYOAqLs4yMDAzMzW04GQwdMwuLVHIObytODU3U6EsVSGxICexuCQzWyExDyiSkqrg4eOo6xLkpJCYk5qTk1qUycPAmpaYU5zKC6W5GWTcXEOcPXRLcxKzkzJz4wuKMnMTiyrjDU1MjYyNCUgDAG9ZLk0</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>AYNA, Tülay</creator><creator>SEYHUN, Yalçın</creator><creator>BEŞIŞIK, Sevgi, Kalayoğlu</creator><creator>KEKİK, Çiğdem</creator><creator>BİLGEN, Hülya</creator><creator>ANAK, Sema</creator><creator>YALMAN, Nevin</creator><creator>SARGIN, Deniz</creator><creator>ÇARİN, Mahmut</creator><creator>OĞUZ, Fatma, Savran</creator><creator>DİLER, A. Sarper</creator><creator>GEDİKOĞLU, Gündüz</creator><general>Gülhane Askeri Tıp Akademisi</general><scope/></search><sort><creationdate>2001</creationdate><title>Akut lösemi ve aplastik anemide HLA-DRB alelleri</title><author>AYNA, Tülay ; SEYHUN, Yalçın ; BEŞIŞIK, Sevgi, Kalayoğlu ; KEKİK, Çiğdem ; BİLGEN, Hülya ; ANAK, Sema ; YALMAN, Nevin ; SARGIN, Deniz ; ÇARİN, Mahmut ; OĞUZ, Fatma, Savran ; DİLER, A. Sarper ; GEDİKOĞLU, Gündüz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-ulakbim_primary_145233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>tur</language><creationdate>2001</creationdate><topic>Alleles</topic><topic>Anemi</topic><topic>Anemia</topic><topic>Gen çiftleri</topic><topic>Genetic processes</topic><topic>Genetik oluşumlar</topic><topic>Hemic and lymphatic diseases</topic><topic>Hemik ve lenfatik hastalıklar</topic><topic>HLA-D Antigens</topic><topic>HLA-D antijenleri</topic><topic>Immunologic and biological factors</topic><topic>İmmünolojik ve biyolojik faktörler</topic><topic>Leukemia, Lymphocytic, Acute</topic><topic>Leukemia, Myelocytic, Acute</topic><topic>Lösemi, lenfositik, akut</topic><topic>Lösemi, miyelositik, akut</topic><topic>Neoplasms</topic><topic>Neoplazmlar</topic><topic>Polimeraz zincir reaksiyonu</topic><topic>Polymerase Chain Reaction</topic><toplevel>online_resources</toplevel><creatorcontrib>AYNA, Tülay</creatorcontrib><creatorcontrib>SEYHUN, Yalçın</creatorcontrib><creatorcontrib>BEŞIŞIK, Sevgi, Kalayoğlu</creatorcontrib><creatorcontrib>KEKİK, Çiğdem</creatorcontrib><creatorcontrib>BİLGEN, Hülya</creatorcontrib><creatorcontrib>ANAK, Sema</creatorcontrib><creatorcontrib>YALMAN, Nevin</creatorcontrib><creatorcontrib>SARGIN, Deniz</creatorcontrib><creatorcontrib>ÇARİN, Mahmut</creatorcontrib><creatorcontrib>OĞUZ, Fatma, Savran</creatorcontrib><creatorcontrib>DİLER, A. Sarper</creatorcontrib><creatorcontrib>GEDİKOĞLU, Gündüz</creatorcontrib><jtitle>Gülhane tıp dergisi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AYNA, Tülay</au><au>SEYHUN, Yalçın</au><au>BEŞIŞIK, Sevgi, Kalayoğlu</au><au>KEKİK, Çiğdem</au><au>BİLGEN, Hülya</au><au>ANAK, Sema</au><au>YALMAN, Nevin</au><au>SARGIN, Deniz</au><au>ÇARİN, Mahmut</au><au>OĞUZ, Fatma, Savran</au><au>DİLER, A. Sarper</au><au>GEDİKOĞLU, Gündüz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Akut lösemi ve aplastik anemide HLA-DRB alelleri</atitle><jtitle>Gülhane tıp dergisi</jtitle><date>2001</date><risdate>2001</risdate><volume>43</volume><issue>3</issue><spage>312</spage><epage>315</epage><pages>312-315</pages><issn>1302-0471</issn><abstract>II. Sınıf HLA antijenleri (HLA-DR) ile aplastik anemi (AA), akut tenfoblastik lösemi (ALL) ve akut myeloid lösemi (AML) ilişkisi çeşitli çalışmalarda gösterilmiştir. Bu çalışmada, DRB aletleri 187 hasta (33 AA, 60AML, 94 ALL) ve 75 kontrol de PCR-SSP yöntemi ile araştırıldı. AA'lı hastalarda DRB1*15 a/e// ile pozitif (p=0.03 OR= 3.4), DRB1*13 aleli ile negatif ilişki (p=0.03, OR=0.13) olduğu gözlendi. AML'Iİ hastalarda ise DRB1*15 ve DRB1*11 aletleri ile pozitif bir ilişki saptandı (p=0.001,OR=3.6, p=0.003 OR=3). ALL'li hastalarda DRB1*14 sıklığı kontrole göre anlamlı olarak düşük bulundu (p=0.006, OR=0.14). AML'Iİ hastalarda DRB5 ve DRB4 aletleri, AA'lı hastalarda DRB5 aleli kontrole göre anlamlı olarak yüksek bulundu (p=0.0002, p=0.005), (p=0.005). Bu aletler ile hastalıklar arasındaki pozitif ilişkinin gösterilmesi, bazı DR aletlerinin akut lösemiler ve aplastik anemi için artmış bir yatkınlık oluşturabileceği sonucu ileri sürülebilir.
Many studies have revealed the relationship of HLA Class II (HLA DR) antigens with aplastic anemia (AA), acute lymphoblastic leukemia (ALL), and acute myeloblastic leukemia (AML). We used the PCR-SSP method on 187 patients (AA: 33, ALL: 94, AML: 60) and 75 control subjects. We found AA to be positively related with DRB1*15 allele (p=0.03, OR= 3.4) and negatively with DRB1*13 (p=0.03, OR=0.13). AML was positively correlated with DRB1*15 and DRB1*11 (p=0.001, OR-3.6, p=0.003, OR=3). The DRB1*14 allele frequency was found to be significantly decreased in the ALL group with respect to the controls (p=0.006, OR-0.14). Increased frequency of DRB5 and DRB4 was observed in the AML group (p= 0.002, p-0.005), whereas only DRB5 enhancement was present in the AA group (p=0.005). The positive correlation found between these alleles and the disease may suggest the susceptibility between several DR a/fetes, acute leukemia and aplastic anemia.</abstract><pub>Gülhane Askeri Tıp Akademisi</pub><oa>free_for_read</oa></addata></record> |
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| language | tur |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Alleles Anemi Anemia Gen çiftleri Genetic processes Genetik oluşumlar Hemic and lymphatic diseases Hemik ve lenfatik hastalıklar HLA-D Antigens HLA-D antijenleri Immunologic and biological factors İmmünolojik ve biyolojik faktörler Leukemia, Lymphocytic, Acute Leukemia, Myelocytic, Acute Lösemi, lenfositik, akut Lösemi, miyelositik, akut Neoplasms Neoplazmlar Polimeraz zincir reaksiyonu Polymerase Chain Reaction |
| title | Akut lösemi ve aplastik anemide HLA-DRB alelleri |
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