Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles
This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-coglycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size...
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| Veröffentlicht in: | Turkish journal of chemistry 2010-01, Vol.34 (4), p.509-516 |
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| container_title | Turkish journal of chemistry |
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| creator | ÇETİN, MELTEM VURAL, İMRAN ATİLA, ALPTUĞ KADIOĞLU, YÜCEL |
| description | This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-coglycolide)
(PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared
via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology
of the PLGA microparticles were also determined. A cytotoxicity test was performed by using
Glioma RG2 cancer cells to investigate the cytotoxicity of DOX-loaded PLGA microparticles. The DOXloaded
PLGA microparticles had an average diameter of 500 ± 9 nm. The DOX encapsulation efficiency and
drug loading were 22.75% and 0.78%, respectively. DOX-loaded PLGA microparticles displayed a significant
cytotoxicity toward the RG2 cells as compared to the unloaded PLGA microparticles. |
| doi_str_mv | 10.3906/kim-0910-237 |
| format | Article |
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(PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared
via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology
of the PLGA microparticles were also determined. A cytotoxicity test was performed by using
Glioma RG2 cancer cells to investigate the cytotoxicity of DOX-loaded PLGA microparticles. The DOXloaded
PLGA microparticles had an average diameter of 500 ± 9 nm. The DOX encapsulation efficiency and
drug loading were 22.75% and 0.78%, respectively. DOX-loaded PLGA microparticles displayed a significant
cytotoxicity toward the RG2 cells as compared to the unloaded PLGA microparticles.</description><identifier>ISSN: 1303-6130</identifier><identifier>ISSN: 1300-0527</identifier><identifier>EISSN: 1303-6130</identifier><identifier>DOI: 10.3906/kim-0910-237</identifier><language>eng</language><publisher>TÜBİTAK</publisher><ispartof>Turkish journal of chemistry, 2010-01, Vol.34 (4), p.509-516</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>ÇETİN, MELTEM</creatorcontrib><creatorcontrib>VURAL, İMRAN</creatorcontrib><creatorcontrib>ATİLA, ALPTUĞ</creatorcontrib><creatorcontrib>KADIOĞLU, YÜCEL</creatorcontrib><title>Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles</title><title>Turkish journal of chemistry</title><description>This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-coglycolide)
(PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared
via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology
of the PLGA microparticles were also determined. A cytotoxicity test was performed by using
Glioma RG2 cancer cells to investigate the cytotoxicity of DOX-loaded PLGA microparticles. The DOXloaded
PLGA microparticles had an average diameter of 500 ± 9 nm. The DOX encapsulation efficiency and
drug loading were 22.75% and 0.78%, respectively. DOX-loaded PLGA microparticles displayed a significant
cytotoxicity toward the RG2 cells as compared to the unloaded PLGA microparticles.</description><issn>1303-6130</issn><issn>1300-0527</issn><issn>1303-6130</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNpNUE1LxDAQDaLgunrzKvQHGE2aNG2Oy6KrsOAe9OIlTNOJxu0Xafegv35TKigM8_Uej5lHyDVnd0Izdb_3DWWaM5qK_IQsuGCCqphP__Xn5GIYvhjjOsaCvO8C9hBg9F2bQFsl9jNOdsTgf-Zl5-J-9BZaiyGpwuGD1h1UWCW-6esIQVljsttuVknjbeiiWmTXOFySMwf1gFe_dUneHh9e1090-7J5Xq-21KZZOlJVWOWyjClMNVibAy-0s9KBRJ2V2hUaS6esVFKwwjHnSsyhQM2BCxm_FktyM-seatiXvjF98A2Eb8O5zIsJv53xeNwwBHR_BGYm30z0zUy-meibOAI6hWIP</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>ÇETİN, MELTEM</creator><creator>VURAL, İMRAN</creator><creator>ATİLA, ALPTUĞ</creator><creator>KADIOĞLU, YÜCEL</creator><general>TÜBİTAK</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20100101</creationdate><title>Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles</title><author>ÇETİN, MELTEM ; VURAL, İMRAN ; ATİLA, ALPTUĞ ; KADIOĞLU, YÜCEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c252t-68c6f5506e29acc7a189fc4fa4e95b9f89ebf6c464308f0ffbe7a8e91a1349063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ÇETİN, MELTEM</creatorcontrib><creatorcontrib>VURAL, İMRAN</creatorcontrib><creatorcontrib>ATİLA, ALPTUĞ</creatorcontrib><creatorcontrib>KADIOĞLU, YÜCEL</creatorcontrib><collection>CrossRef</collection><jtitle>Turkish journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ÇETİN, MELTEM</au><au>VURAL, İMRAN</au><au>ATİLA, ALPTUĞ</au><au>KADIOĞLU, YÜCEL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles</atitle><jtitle>Turkish journal of chemistry</jtitle><date>2010-01-01</date><risdate>2010</risdate><volume>34</volume><issue>4</issue><spage>509</spage><epage>516</epage><pages>509-516</pages><issn>1303-6130</issn><issn>1300-0527</issn><eissn>1303-6130</eissn><abstract>This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-coglycolide)
(PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared
via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology
of the PLGA microparticles were also determined. A cytotoxicity test was performed by using
Glioma RG2 cancer cells to investigate the cytotoxicity of DOX-loaded PLGA microparticles. The DOXloaded
PLGA microparticles had an average diameter of 500 ± 9 nm. The DOX encapsulation efficiency and
drug loading were 22.75% and 0.78%, respectively. DOX-loaded PLGA microparticles displayed a significant
cytotoxicity toward the RG2 cells as compared to the unloaded PLGA microparticles.</abstract><pub>TÜBİTAK</pub><doi>10.3906/kim-0910-237</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1303-6130 |
| ispartof | Turkish journal of chemistry, 2010-01, Vol.34 (4), p.509-516 |
| issn | 1303-6130 1300-0527 1303-6130 |
| language | eng |
| recordid | cdi_ulakbim_primary_114786 |
| source | TÜBİTAK Scientific Journals; EZB Electronic Journals Library |
| title | Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles |
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