The prevalence of CYP2C19 mutations in Turkish patients with dyspepsia
We aimed to determine the distribution of cytochrome P450 2C19 (CYP2C19) genotype frequencies in Turkish patients with dyspepsia. CYP2C19 genotype was determined in 100 Turkish patients with dyspepsia. DNA of the patients was isolated from whole blood and genotypes were detected by specific probes i...
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| Veröffentlicht in: | The Turkish journal of gastroenterology 2009-09, Vol.20 (3), p.161-164 |
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| container_title | The Turkish journal of gastroenterology |
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| creator | Celebi, Altay Kocaman, Orhan Savli, Hakan Aygün, Cem Konduk, Buğra Tolga Sentürk, Omer Hülagu, Sadettin |
| description | We aimed to determine the distribution of cytochrome P450 2C19 (CYP2C19) genotype frequencies in Turkish patients with dyspepsia.
CYP2C19 genotype was determined in 100 Turkish patients with dyspepsia. DNA of the patients was isolated from whole blood and genotypes were detected by specific probes in real-time polymerase chain reaction (PCR).
The frequencies of heterozygous CYP2C19*2 and CYP2C19*3 genotypes were 13% and 1% in dyspeptic patients, respectively. Homozygous mutant CYP2C19*2 was detected at a rate of only 1% in the study population, and homozygous mutant genotype of CYP2C19*3 was not found. The frequencies of homozygous CYP2C19*2 and CYP2C19*3 genotypes were 86% and 99% in dyspeptic Turkish patients, respectively.
This is the first study investigating CYP2C19 polymorphism in dyspeptic Turkish patients. Our investigation revealed that the most common CYP2C19 genotype was wild type CYP2C19 in dyspeptic Turkish patients. Dyspeptic Turkish patients are extensive metabolizers for proton pump inhibitors. This finding might have impact on the clinical consequences for the treatment strategies in dyspepsia. |
| doi_str_mv | 10.4318/tjg.2009.0001 |
| format | Article |
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CYP2C19 genotype was determined in 100 Turkish patients with dyspepsia. DNA of the patients was isolated from whole blood and genotypes were detected by specific probes in real-time polymerase chain reaction (PCR).
The frequencies of heterozygous CYP2C19*2 and CYP2C19*3 genotypes were 13% and 1% in dyspeptic patients, respectively. Homozygous mutant CYP2C19*2 was detected at a rate of only 1% in the study population, and homozygous mutant genotype of CYP2C19*3 was not found. The frequencies of homozygous CYP2C19*2 and CYP2C19*3 genotypes were 86% and 99% in dyspeptic Turkish patients, respectively.
This is the first study investigating CYP2C19 polymorphism in dyspeptic Turkish patients. Our investigation revealed that the most common CYP2C19 genotype was wild type CYP2C19 in dyspeptic Turkish patients. Dyspeptic Turkish patients are extensive metabolizers for proton pump inhibitors. This finding might have impact on the clinical consequences for the treatment strategies in dyspepsia.</description><identifier>ISSN: 1300-4948</identifier><identifier>EISSN: 2148-5607</identifier><identifier>DOI: 10.4318/tjg.2009.0001</identifier><identifier>PMID: 19821196</identifier><language>eng</language><publisher>Turkey: Türk Gastroenteroloji Vakfı</publisher><subject>Adult ; Aryl Hydrocarbon Hydroxylases - genetics ; Cytochrome P-450 CYP2C19 ; Dyspepsia - epidemiology ; Dyspepsia - genetics ; Female ; Genetic Predisposition to Disease - epidemiology ; Genotype ; Homozygote ; Humans ; Male ; Middle Aged ; Prevalence ; Turkey - epidemiology ; Young Adult</subject><ispartof>The Turkish journal of gastroenterology, 2009-09, Vol.20 (3), p.161-164</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-d02d80e91c42fdc40096b1c5dfba541d3d39144669e135f8f99c9c014c2b51cf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19821196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Celebi, Altay</creatorcontrib><creatorcontrib>Kocaman, Orhan</creatorcontrib><creatorcontrib>Savli, Hakan</creatorcontrib><creatorcontrib>Aygün, Cem</creatorcontrib><creatorcontrib>Konduk, Buğra Tolga</creatorcontrib><creatorcontrib>Sentürk, Omer</creatorcontrib><creatorcontrib>Hülagu, Sadettin</creatorcontrib><title>The prevalence of CYP2C19 mutations in Turkish patients with dyspepsia</title><title>The Turkish journal of gastroenterology</title><addtitle>Turk J Gastroenterol</addtitle><description>We aimed to determine the distribution of cytochrome P450 2C19 (CYP2C19) genotype frequencies in Turkish patients with dyspepsia.
CYP2C19 genotype was determined in 100 Turkish patients with dyspepsia. DNA of the patients was isolated from whole blood and genotypes were detected by specific probes in real-time polymerase chain reaction (PCR).
The frequencies of heterozygous CYP2C19*2 and CYP2C19*3 genotypes were 13% and 1% in dyspeptic patients, respectively. Homozygous mutant CYP2C19*2 was detected at a rate of only 1% in the study population, and homozygous mutant genotype of CYP2C19*3 was not found. The frequencies of homozygous CYP2C19*2 and CYP2C19*3 genotypes were 86% and 99% in dyspeptic Turkish patients, respectively.
This is the first study investigating CYP2C19 polymorphism in dyspeptic Turkish patients. Our investigation revealed that the most common CYP2C19 genotype was wild type CYP2C19 in dyspeptic Turkish patients. Dyspeptic Turkish patients are extensive metabolizers for proton pump inhibitors. This finding might have impact on the clinical consequences for the treatment strategies in dyspepsia.</description><subject>Adult</subject><subject>Aryl Hydrocarbon Hydroxylases - genetics</subject><subject>Cytochrome P-450 CYP2C19</subject><subject>Dyspepsia - epidemiology</subject><subject>Dyspepsia - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genotype</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Turkey - epidemiology</subject><subject>Young Adult</subject><issn>1300-4948</issn><issn>2148-5607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtLw0AUhQdRbK0uXSqzc5V678wknVlKsSoUdFEXrsJkHjZtXmYSpf_elBZ0deGcj8PlI-QaYSo4yvtu8zllAGoKAHhCxgyFjOIEZqdkjBwgEkrIEbkIYQPAJSbsnIxQSYaokjFZrNaONq371oWrjKO1p_OPNzZHRcu-011eV4HmFV317TYPa9oMkau6QH_ybk3tLjSuCbm-JGdeF8FdHe-EvC8eV_PnaPn69DJ_WEaGo-giC8xKcAqNYN4aMfydZGhi6zMdC7TccoVCJIlyyGMvvVJGGUBhWBaj8XxCbg67faG3WV6mTZuXut2lCMlMwNDfHfqmrb96F7q0zINxRaErV_chnXEBEhkTAxkdSNPWIbTO_5tK92bTwWy6N5vuzQ787XG5z0pn_-ijSv4LeSZyXA</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Celebi, Altay</creator><creator>Kocaman, Orhan</creator><creator>Savli, Hakan</creator><creator>Aygün, Cem</creator><creator>Konduk, Buğra Tolga</creator><creator>Sentürk, Omer</creator><creator>Hülagu, Sadettin</creator><general>Türk Gastroenteroloji Vakfı</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GIY</scope><scope>GIZ</scope><scope>GJA</scope><scope>GJB</scope></search><sort><creationdate>20090901</creationdate><title>The prevalence of CYP2C19 mutations in Turkish patients with dyspepsia</title><author>Celebi, Altay ; Kocaman, Orhan ; Savli, Hakan ; Aygün, Cem ; Konduk, Buğra Tolga ; Sentürk, Omer ; Hülagu, Sadettin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-d02d80e91c42fdc40096b1c5dfba541d3d39144669e135f8f99c9c014c2b51cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aryl Hydrocarbon Hydroxylases - genetics</topic><topic>Cytochrome P-450 CYP2C19</topic><topic>Dyspepsia - epidemiology</topic><topic>Dyspepsia - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genotype</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Turkey - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Celebi, Altay</creatorcontrib><creatorcontrib>Kocaman, Orhan</creatorcontrib><creatorcontrib>Savli, Hakan</creatorcontrib><creatorcontrib>Aygün, Cem</creatorcontrib><creatorcontrib>Konduk, Buğra Tolga</creatorcontrib><creatorcontrib>Sentürk, Omer</creatorcontrib><creatorcontrib>Hülagu, Sadettin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ULAKBIM - Mühendislik ve Temel Bilimler Veri Tabani</collection><collection>ULAKBIM - Yaşam Bilimleri Veri Tabani</collection><collection>ULAKBIM - Turk Sosyal Bilimler Veri Tabani</collection><collection>ULAKBIM - Türk Tıp Veri Tabani</collection><jtitle>The Turkish journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Celebi, Altay</au><au>Kocaman, Orhan</au><au>Savli, Hakan</au><au>Aygün, Cem</au><au>Konduk, Buğra Tolga</au><au>Sentürk, Omer</au><au>Hülagu, Sadettin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prevalence of CYP2C19 mutations in Turkish patients with dyspepsia</atitle><jtitle>The Turkish journal of gastroenterology</jtitle><addtitle>Turk J Gastroenterol</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>20</volume><issue>3</issue><spage>161</spage><epage>164</epage><pages>161-164</pages><issn>1300-4948</issn><eissn>2148-5607</eissn><abstract>We aimed to determine the distribution of cytochrome P450 2C19 (CYP2C19) genotype frequencies in Turkish patients with dyspepsia.
CYP2C19 genotype was determined in 100 Turkish patients with dyspepsia. DNA of the patients was isolated from whole blood and genotypes were detected by specific probes in real-time polymerase chain reaction (PCR).
The frequencies of heterozygous CYP2C19*2 and CYP2C19*3 genotypes were 13% and 1% in dyspeptic patients, respectively. Homozygous mutant CYP2C19*2 was detected at a rate of only 1% in the study population, and homozygous mutant genotype of CYP2C19*3 was not found. The frequencies of homozygous CYP2C19*2 and CYP2C19*3 genotypes were 86% and 99% in dyspeptic Turkish patients, respectively.
This is the first study investigating CYP2C19 polymorphism in dyspeptic Turkish patients. Our investigation revealed that the most common CYP2C19 genotype was wild type CYP2C19 in dyspeptic Turkish patients. Dyspeptic Turkish patients are extensive metabolizers for proton pump inhibitors. This finding might have impact on the clinical consequences for the treatment strategies in dyspepsia.</abstract><cop>Turkey</cop><pub>Türk Gastroenteroloji Vakfı</pub><pmid>19821196</pmid><doi>10.4318/tjg.2009.0001</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1300-4948 |
| ispartof | The Turkish journal of gastroenterology, 2009-09, Vol.20 (3), p.161-164 |
| issn | 1300-4948 2148-5607 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aryl Hydrocarbon Hydroxylases - genetics Cytochrome P-450 CYP2C19 Dyspepsia - epidemiology Dyspepsia - genetics Female Genetic Predisposition to Disease - epidemiology Genotype Homozygote Humans Male Middle Aged Prevalence Turkey - epidemiology Young Adult |
| title | The prevalence of CYP2C19 mutations in Turkish patients with dyspepsia |
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