Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity
Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by $^1H$-NMR, mas...
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| Veröffentlicht in: | Turkish journal of chemistry 2010-01, Vol.34 (1), p.57-65 |
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| container_title | Turkish journal of chemistry |
| container_volume | 34 |
| creator | DOĞRUER, DENİZ S. URLU, ŞÖLEN ÖNKOL, TİJEN ÖZÇELİK, BERRİN ŞAHİN, M. FETHİ |
| description | Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and
evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by
using broth microdilution. The structures of these new compounds were confirmed by $^1H$-NMR, mass
spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory
activity against S. aureus (MIC ranging from 2 to 4 μg/mL) and E. coli (MIC ranging from 4 to 16
μg/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis,
with a MIC value of 8 μg/mL. |
| doi_str_mv | 10.3906/kim-0904-27 |
| format | Article |
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evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by
using broth microdilution. The structures of these new compounds were confirmed by $^1H$-NMR, mass
spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory
activity against S. aureus (MIC ranging from 2 to 4 &#956;g/mL) and E. coli (MIC ranging from 4 to 16
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evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by
using broth microdilution. The structures of these new compounds were confirmed by $^1H$-NMR, mass
spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory
activity against S. aureus (MIC ranging from 2 to 4 &#956;g/mL) and E. coli (MIC ranging from 4 to 16
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evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by
using broth microdilution. The structures of these new compounds were confirmed by $^1H$-NMR, mass
spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory
activity against S. aureus (MIC ranging from 2 to 4 &#956;g/mL) and E. coli (MIC ranging from 4 to 16
&#956;g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis,
with a MIC value of 8 &#956;g/mL.</abstract><pub>TÜBİTAK</pub><doi>10.3906/kim-0904-27</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1303-6130 |
| ispartof | Turkish journal of chemistry, 2010-01, Vol.34 (1), p.57-65 |
| issn | 1303-6130 1300-0527 1303-6130 |
| language | eng |
| recordid | cdi_ulakbim_primary_106021 |
| source | EZB-FREE-00999 freely available EZB journals; TÜBİTAK Scientific Journals |
| title | Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity |
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