Synthesis of methyl1 (E)-2' ,4'' -thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities

Synthesis of methyl1 (E)-2' ,4'' -thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities

A series of 9 new (E) -thiazachalcones (1-3), and their N -alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa. The new compounds (1-6) without dime...

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Veröffentlicht in:Turkish journal of chemistry 2009, Vol.33 (5), p.621-632
Hauptverfasser: USTA, Asu, YAYLI, Nurettin, YAYLI, Nuran, KARAOĞLU, Şengül, Alpay, YAŞAR, Ahmet
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container_end_page 632
container_issue 5
container_start_page 621
container_title Turkish journal of chemistry
container_volume 33
creator USTA, Asu
YAYLI, Nurettin
YAYLI, Nuran
KARAOĞLU, Şengül, Alpay
YAŞAR, Ahmet
description A series of 9 new (E) -thiazachalcones (1-3), and their N -alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa. The new compounds (1-6) without dimerization products (7-9) showed good antimicrobial property against Staphylococcus aureus, Listeria monocitogenes, and Enterococcus faecalis. The possible dimerization products of compounds (1-3) were calculated theoretically. Experimental and theoretical calculation showed that δ -truxinic type dimer is the most stable isomer.
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title Synthesis of methyl1 (E)-2' ,4'' -thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities
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