The rs3857059 variant of the SNCAgene is associated with Parkinson’s disease in Mexican Mestizos
ABSTRACT Among the candidate genes for Parkinson’s disease (PD), SNCA has replicated association in different populations. Besides other known mutations in the SNCA gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to...
Gespeichert in:
| Veröffentlicht in: | Arquivos de neuro-psiquiatria 2016-06, Vol.74 (6), p.445-449 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 449 |
|---|---|
| container_issue | 6 |
| container_start_page | 445 |
| container_title | Arquivos de neuro-psiquiatria |
| container_volume | 74 |
| creator | García, S. Chavira-Hernández, G. Gallegos-Arreola, M.P Dávila-Maldonado, L. García Martínez, F. Montes Almanza, L.A Palma-Flores, C. Mondragón-Terán, P. Alcaraz Estrada, S.L. López-Hernández, L. B. |
| description | ABSTRACT
Among the candidate genes for Parkinson’s disease (PD),
SNCA
has replicated association in different populations. Besides other known mutations in the
SNCA
gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population. |
| doi_str_mv | 10.1590/0004-282X20160061 |
| format | Article |
| fullrecord | <record><control><sourceid>thieme</sourceid><recordid>TN_cdi_thieme_journals_10_1590_0004_282X20160061</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1590_0004_282X20160061</sourcerecordid><originalsourceid>FETCH-thieme_journals_10_1590_0004_282X201600613</originalsourceid><addsrcrecordid>eNqdj01KA0EQhZtgIKPJAbKrC4xWd-Z3KcHgRgkkC3dNm1QylWg3TLU_uPIaXs-TZAZEXLt6i-89eJ9SU42XOq_xChGz1FTmwaAuEAs9UIkuyirNjCnPVPLLR-pc5IBosrouE_W4bghamVV5iXkNr65l5yOEHcQOrO7n13vyBCzgRMKGXaQtvHFsYOnaI3sJ_vvzS2DLQk66ooc7eueN61MifwQZq-HOPQlNfvJC4eJmPb9NY8P0TPYQXlrfAavR9i62_2r_usz-MTkBfjZQgQ</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The rs3857059 variant of the SNCAgene is associated with Parkinson’s disease in Mexican Mestizos</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Thieme Connect Journals Open Access</source><creator>García, S. ; Chavira-Hernández, G. ; Gallegos-Arreola, M.P ; Dávila-Maldonado, L. ; García Martínez, F. ; Montes Almanza, L.A ; Palma-Flores, C. ; Mondragón-Terán, P. ; Alcaraz Estrada, S.L. ; López-Hernández, L. B.</creator><creatorcontrib>García, S. ; Chavira-Hernández, G. ; Gallegos-Arreola, M.P ; Dávila-Maldonado, L. ; García Martínez, F. ; Montes Almanza, L.A ; Palma-Flores, C. ; Mondragón-Terán, P. ; Alcaraz Estrada, S.L. ; López-Hernández, L. B.</creatorcontrib><description>ABSTRACT
Among the candidate genes for Parkinson’s disease (PD),
SNCA
has replicated association in different populations. Besides other known mutations in the
SNCA
gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population.</description><identifier>ISSN: 0004-282X</identifier><identifier>EISSN: 1678-4227</identifier><identifier>DOI: 10.1590/0004-282X20160061</identifier><language>eng</language><publisher>Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil: Thieme Revinter Publicações Ltda</publisher><ispartof>Arquivos de neuro-psiquiatria, 2016-06, Vol.74 (6), p.445-449</ispartof><rights>Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1590/0004-282X20160061.pdf$$EPDF$$P50$$Gthieme$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1590/0004-282X20160061$$EHTML$$P50$$Gthieme$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,20871,27903,27904,54566,54594</link.rule.ids></links><search><creatorcontrib>García, S.</creatorcontrib><creatorcontrib>Chavira-Hernández, G.</creatorcontrib><creatorcontrib>Gallegos-Arreola, M.P</creatorcontrib><creatorcontrib>Dávila-Maldonado, L.</creatorcontrib><creatorcontrib>García Martínez, F.</creatorcontrib><creatorcontrib>Montes Almanza, L.A</creatorcontrib><creatorcontrib>Palma-Flores, C.</creatorcontrib><creatorcontrib>Mondragón-Terán, P.</creatorcontrib><creatorcontrib>Alcaraz Estrada, S.L.</creatorcontrib><creatorcontrib>López-Hernández, L. B.</creatorcontrib><title>The rs3857059 variant of the SNCAgene is associated with Parkinson’s disease in Mexican Mestizos</title><title>Arquivos de neuro-psiquiatria</title><addtitle>Arq Neuropsiquiatr</addtitle><description>ABSTRACT
Among the candidate genes for Parkinson’s disease (PD),
SNCA
has replicated association in different populations. Besides other known mutations in the
SNCA
gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population.</description><issn>0004-282X</issn><issn>1678-4227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>0U6</sourceid><recordid>eNqdj01KA0EQhZtgIKPJAbKrC4xWd-Z3KcHgRgkkC3dNm1QylWg3TLU_uPIaXs-TZAZEXLt6i-89eJ9SU42XOq_xChGz1FTmwaAuEAs9UIkuyirNjCnPVPLLR-pc5IBosrouE_W4bghamVV5iXkNr65l5yOEHcQOrO7n13vyBCzgRMKGXaQtvHFsYOnaI3sJ_vvzS2DLQk66ooc7eueN61MifwQZq-HOPQlNfvJC4eJmPb9NY8P0TPYQXlrfAavR9i62_2r_usz-MTkBfjZQgQ</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>García, S.</creator><creator>Chavira-Hernández, G.</creator><creator>Gallegos-Arreola, M.P</creator><creator>Dávila-Maldonado, L.</creator><creator>García Martínez, F.</creator><creator>Montes Almanza, L.A</creator><creator>Palma-Flores, C.</creator><creator>Mondragón-Terán, P.</creator><creator>Alcaraz Estrada, S.L.</creator><creator>López-Hernández, L. B.</creator><general>Thieme Revinter Publicações Ltda</general><scope>0U6</scope></search><sort><creationdate>201606</creationdate><title>The rs3857059 variant of the SNCAgene is associated with Parkinson’s disease in Mexican Mestizos</title><author>García, S. ; Chavira-Hernández, G. ; Gallegos-Arreola, M.P ; Dávila-Maldonado, L. ; García Martínez, F. ; Montes Almanza, L.A ; Palma-Flores, C. ; Mondragón-Terán, P. ; Alcaraz Estrada, S.L. ; López-Hernández, L. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-thieme_journals_10_1590_0004_282X201600613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García, S.</creatorcontrib><creatorcontrib>Chavira-Hernández, G.</creatorcontrib><creatorcontrib>Gallegos-Arreola, M.P</creatorcontrib><creatorcontrib>Dávila-Maldonado, L.</creatorcontrib><creatorcontrib>García Martínez, F.</creatorcontrib><creatorcontrib>Montes Almanza, L.A</creatorcontrib><creatorcontrib>Palma-Flores, C.</creatorcontrib><creatorcontrib>Mondragón-Terán, P.</creatorcontrib><creatorcontrib>Alcaraz Estrada, S.L.</creatorcontrib><creatorcontrib>López-Hernández, L. B.</creatorcontrib><collection>Thieme Connect Journals Open Access</collection><jtitle>Arquivos de neuro-psiquiatria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García, S.</au><au>Chavira-Hernández, G.</au><au>Gallegos-Arreola, M.P</au><au>Dávila-Maldonado, L.</au><au>García Martínez, F.</au><au>Montes Almanza, L.A</au><au>Palma-Flores, C.</au><au>Mondragón-Terán, P.</au><au>Alcaraz Estrada, S.L.</au><au>López-Hernández, L. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The rs3857059 variant of the SNCAgene is associated with Parkinson’s disease in Mexican Mestizos</atitle><jtitle>Arquivos de neuro-psiquiatria</jtitle><addtitle>Arq Neuropsiquiatr</addtitle><date>2016-06</date><risdate>2016</risdate><volume>74</volume><issue>6</issue><spage>445</spage><epage>449</epage><pages>445-449</pages><issn>0004-282X</issn><eissn>1678-4227</eissn><abstract>ABSTRACT
Among the candidate genes for Parkinson’s disease (PD),
SNCA
has replicated association in different populations. Besides other known mutations in the
SNCA
gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population.</abstract><cop>Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil</cop><pub>Thieme Revinter Publicações Ltda</pub><doi>10.1590/0004-282X20160061</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0004-282X |
| ispartof | Arquivos de neuro-psiquiatria, 2016-06, Vol.74 (6), p.445-449 |
| issn | 0004-282X 1678-4227 |
| language | eng |
| recordid | cdi_thieme_journals_10_1590_0004_282X20160061 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Thieme Connect Journals Open Access |
| title | The rs3857059 variant of the SNCAgene is associated with Parkinson’s disease in Mexican Mestizos |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T05%3A14%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-thieme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20rs3857059%20variant%20of%20the%20SNCAgene%20is%20associated%20with%20Parkinson%E2%80%99s%20disease%20in%20Mexican%20Mestizos&rft.jtitle=Arquivos%20de%20neuro-psiquiatria&rft.au=Garc%C3%ADa,%20S.&rft.date=2016-06&rft.volume=74&rft.issue=6&rft.spage=445&rft.epage=449&rft.pages=445-449&rft.issn=0004-282X&rft.eissn=1678-4227&rft_id=info:doi/10.1590/0004-282X20160061&rft_dat=%3Cthieme%3E10_1590_0004_282X20160061%3C/thieme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |