A model-based analysis of the clinical and economic impact of personalising P2Y12-receptor inhibition with platelet function testing in acute coronary syndrome patients

Although some observational studies reported that the measured level of P2Y12-inhibition is predictive for thrombotic events, the clinical and economic benefit of incorporating PFT to personalize P2Y12-receptor directed antiplatelet treatment is unknown. Here, we assessed the clinical impact and cos...

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Veröffentlicht in:	Thrombosis and haemostasis 2014-02, Vol.111 (2), p.290-299
Hauptverfasser:	Straub, Niels, Beivers, Andreas, Lenk, Ekaterina, Aradi, Daniel, Sibbing, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndrome Acute Coronary Syndrome - blood Acute Coronary Syndrome - diagnosis Acute Coronary Syndrome - drug therapy Acute Coronary Syndrome - economics Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism clopidogrel Cost-Benefit Analysis cost-effectiveness Decision Support Techniques Decision Trees Drug Costs Fundamental and applied biological sciences. Psychology health economics Hematologic and hematopoietic diseases Humans Medical sciences Models, Economic Molecular and cellular biology Patient Selection Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - economics Platelet Aggregation Inhibitors - therapeutic use Platelet diseases and coagulopathies platelet function testing Platelet Function Tests - economics Platelets and Blood Cells prasugrel Precision Medicine - economics Predictive Value of Tests Purinergic P2Y Receptor Antagonists - adverse effects Purinergic P2Y Receptor Antagonists - economics Purinergic P2Y Receptor Antagonists - therapeutic use Receptors, Purinergic P2Y12 - blood Receptors, Purinergic P2Y12 - drug effects Risk Assessment Risk Factors ticagrelor Treatment Outcome
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