Hyperresponsiveness of platelets in ischemic stroke
Summary Platelet activation and aggregation are critical in the pathogenesis of acute ischemic cerebrovascular diseases. The aim of our study was to characterize platelet function in patients with acute ischemic stroke or transient ischemic attack (TIA), and to evaluate the effect of platelet activa...
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| Veröffentlicht in: | Thrombosis and haemostasis 2007-06, Vol.97 (6), p.974-978 |
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| creator | Fateh-Moghadam, Suzanne Htun, Patrik Tomandl, Bernd Sander, Dirk Stellos, Konstantinos Geisler, Tobias Langer, Harald Walton, Kodwo Handschu, Rene Garlichs, Christoph Daniel, Werner G. Gawaz, Meinrad |
| description | Summary
Platelet activation and aggregation are critical in the pathogenesis of acute ischemic cerebrovascular diseases. The aim of our study was to characterize platelet function in patients with acute ischemic stroke or transient ischemic attack (TIA), and to evaluate the effect of platelet activation on clinical outcome. One hundred thirty-eight consecutive patients with TIA (n=74) or stroke (n=64) were enrolled in this study. Platelet aggregation in response to ADP, epinephrine, arachidonic acid, or collagen, and expression of platelet activation receptors (CD62P, CD63, LIBS-1 and PAC-1) in the acute phase and at three months follow-up were evaluated. Platelets derived from stroke patients were more hyperaggregable in response to agonists in the acute phase compared to TIA patients (p[ADP]=0.002, p[arachidonic acid]=0.047, p[epinephrine]=0.020). Platelet activation was enhanced in the acute phase irrespective of the severity of the disease (stroke or TIA) and returned to baseline levels three months later. Persistent elevated platelet activation at three months follow-up (PAC-1) was associated with increased incidence of recurrent stroke (median, [interquartile range] 3.4, [3.0–5.2] versus 2.9, [2.3–4.0], p=0.048). In conclusion, platelets are hyperactive in acute stroke compared with TIA. A more intensified dual antiplatelet therapy may be of benefit for stroke patients. |
| doi_str_mv | 10.1160/th06-12-0725 |
| format | Article |
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Platelet activation and aggregation are critical in the pathogenesis of acute ischemic cerebrovascular diseases. The aim of our study was to characterize platelet function in patients with acute ischemic stroke or transient ischemic attack (TIA), and to evaluate the effect of platelet activation on clinical outcome. One hundred thirty-eight consecutive patients with TIA (n=74) or stroke (n=64) were enrolled in this study. Platelet aggregation in response to ADP, epinephrine, arachidonic acid, or collagen, and expression of platelet activation receptors (CD62P, CD63, LIBS-1 and PAC-1) in the acute phase and at three months follow-up were evaluated. Platelets derived from stroke patients were more hyperaggregable in response to agonists in the acute phase compared to TIA patients (p[ADP]=0.002, p[arachidonic acid]=0.047, p[epinephrine]=0.020). Platelet activation was enhanced in the acute phase irrespective of the severity of the disease (stroke or TIA) and returned to baseline levels three months later. Persistent elevated platelet activation at three months follow-up (PAC-1) was associated with increased incidence of recurrent stroke (median, [interquartile range] 3.4, [3.0–5.2] versus 2.9, [2.3–4.0], p=0.048). In conclusion, platelets are hyperactive in acute stroke compared with TIA. A more intensified dual antiplatelet therapy may be of benefit for stroke patients.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1160/th06-12-0725</identifier><identifier>PMID: 17549300</identifier><identifier>CODEN: THHADQ</identifier><language>eng</language><publisher>Stuttgart: Schattauer Verlag für Medizin und Naturwissenschaften</publisher><subject>Adenosine Diphosphate - metabolism ; Adult ; Aged ; Arachidonic Acid - metabolism ; Biological and medical sciences ; Biomarkers - blood ; Blood coagulation. Blood cells ; Blood Platelets - metabolism ; Brain Ischemia - blood ; Brain Ischemia - complications ; Brain Ischemia - mortality ; Collagen - metabolism ; Epinephrine - metabolism ; Female ; flow cytometry ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Hematologic and hematopoietic diseases ; Humans ; Ischemic Attack, Transient - blood ; Ischemic Attack, Transient - diagnosis ; Ischemic Attack, Transient - etiology ; Ischemic Attack, Transient - mortality ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Molecular and cellular biology ; Platelet Activation ; Platelet Aggregation ; Platelet diseases and coagulopathies ; Platelet Function Tests ; Platelets and Blood Cells ; Predictive Value of Tests ; Recurrence ; Risk Assessment ; Risk Factors ; ROC Curve ; Severity of Illness Index ; Stroke ; Stroke - blood ; Stroke - diagnosis ; Stroke - etiology ; Stroke - mortality ; Time Factors ; Transient ischemic attack</subject><ispartof>Thrombosis and haemostasis, 2007-06, Vol.97 (6), p.974-978</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c756t-41f7ea409be14a54fdf66afa5b829a98f12b8885370e09529c88818c46e688ea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH06-12-0725.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1160/TH06-12-0725$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18803241$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17549300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fateh-Moghadam, Suzanne</creatorcontrib><creatorcontrib>Htun, Patrik</creatorcontrib><creatorcontrib>Tomandl, Bernd</creatorcontrib><creatorcontrib>Sander, Dirk</creatorcontrib><creatorcontrib>Stellos, Konstantinos</creatorcontrib><creatorcontrib>Geisler, Tobias</creatorcontrib><creatorcontrib>Langer, Harald</creatorcontrib><creatorcontrib>Walton, Kodwo</creatorcontrib><creatorcontrib>Handschu, Rene</creatorcontrib><creatorcontrib>Garlichs, Christoph</creatorcontrib><creatorcontrib>Daniel, Werner G.</creatorcontrib><creatorcontrib>Gawaz, Meinrad</creatorcontrib><title>Hyperresponsiveness of platelets in ischemic stroke</title><title>Thrombosis and haemostasis</title><addtitle>Thromb Haemost</addtitle><description>Summary
Platelet activation and aggregation are critical in the pathogenesis of acute ischemic cerebrovascular diseases. The aim of our study was to characterize platelet function in patients with acute ischemic stroke or transient ischemic attack (TIA), and to evaluate the effect of platelet activation on clinical outcome. One hundred thirty-eight consecutive patients with TIA (n=74) or stroke (n=64) were enrolled in this study. Platelet aggregation in response to ADP, epinephrine, arachidonic acid, or collagen, and expression of platelet activation receptors (CD62P, CD63, LIBS-1 and PAC-1) in the acute phase and at three months follow-up were evaluated. Platelets derived from stroke patients were more hyperaggregable in response to agonists in the acute phase compared to TIA patients (p[ADP]=0.002, p[arachidonic acid]=0.047, p[epinephrine]=0.020). Platelet activation was enhanced in the acute phase irrespective of the severity of the disease (stroke or TIA) and returned to baseline levels three months later. Persistent elevated platelet activation at three months follow-up (PAC-1) was associated with increased incidence of recurrent stroke (median, [interquartile range] 3.4, [3.0–5.2] versus 2.9, [2.3–4.0], p=0.048). In conclusion, platelets are hyperactive in acute stroke compared with TIA. A more intensified dual antiplatelet therapy may be of benefit for stroke patients.</description><subject>Adenosine Diphosphate - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Arachidonic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Platelets - metabolism</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - complications</subject><subject>Brain Ischemia - mortality</subject><subject>Collagen - metabolism</subject><subject>Epinephrine - metabolism</subject><subject>Female</subject><subject>flow cytometry</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Ischemic Attack, Transient - blood</subject><subject>Ischemic Attack, Transient - diagnosis</subject><subject>Ischemic Attack, Transient - etiology</subject><subject>Ischemic Attack, Transient - mortality</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>Platelet Activation</subject><subject>Platelet Aggregation</subject><subject>Platelet diseases and coagulopathies</subject><subject>Platelet Function Tests</subject><subject>Platelets and Blood Cells</subject><subject>Predictive Value of Tests</subject><subject>Recurrence</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><subject>Stroke</subject><subject>Stroke - blood</subject><subject>Stroke - diagnosis</subject><subject>Stroke - etiology</subject><subject>Stroke - mortality</subject><subject>Time Factors</subject><subject>Transient ischemic attack</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNq1kT1vFDEQhlcIRI5AR42ugSYs2F5_bRlFwCFFogkSneX1zWod1vbi8Qbl3-PTnUgFFVTWyI_eZ_RO07yk5B2lkrwvE5EtZS1RTDxqNkxI1Urdf3vcbEjHSSsZF2fNM8RbQqjkvXjanFEleN8Rsmm63f0COQMuKaK_gwiI2zRul9kWmKHg1setRzdB8G6LJafv8Lx5MtoZ4cXpPW--fvxwc7Vrr798-nx1ed06JWRpOR0VWE76ASi3go_7UUo7WjFo1ttej5QNWmvRKQKkF6x3daLacQlSa7DdefPmmLvk9GMFLCbUTWCebYS0olFEKEYJqeDbI-hyQswwmiX7YPO9ocQcSjI3OyINZeZQUsVfnXLXIcD-AT61UoHXJ8Cis_OYbXQeHzitScc4rdzFkSuThwDmNq051kb-pPVHurZpS7Er5N-RZcopDAmrxca9mSyEhMUeZpdigVjqR3ZTvZDxiCsY1UkTbFzRZb8UoxlTBqf000wlzNUV_qELF3Dezn_1uf_v634B3WL5IA</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Fateh-Moghadam, Suzanne</creator><creator>Htun, Patrik</creator><creator>Tomandl, Bernd</creator><creator>Sander, Dirk</creator><creator>Stellos, Konstantinos</creator><creator>Geisler, Tobias</creator><creator>Langer, Harald</creator><creator>Walton, Kodwo</creator><creator>Handschu, Rene</creator><creator>Garlichs, Christoph</creator><creator>Daniel, Werner G.</creator><creator>Gawaz, Meinrad</creator><general>Schattauer Verlag für Medizin und Naturwissenschaften</general><general>Schattauer GmbH</general><general>Schattauer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Hyperresponsiveness of platelets in ischemic stroke</title><author>Fateh-Moghadam, Suzanne ; Htun, Patrik ; Tomandl, Bernd ; Sander, Dirk ; Stellos, Konstantinos ; Geisler, Tobias ; Langer, Harald ; Walton, Kodwo ; Handschu, Rene ; Garlichs, Christoph ; Daniel, Werner G. ; Gawaz, Meinrad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c756t-41f7ea409be14a54fdf66afa5b829a98f12b8885370e09529c88818c46e688ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenosine Diphosphate - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Arachidonic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Platelets - metabolism</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - complications</topic><topic>Brain Ischemia - mortality</topic><topic>Collagen - metabolism</topic><topic>Epinephrine - metabolism</topic><topic>Female</topic><topic>flow cytometry</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Ischemic Attack, Transient - blood</topic><topic>Ischemic Attack, Transient - diagnosis</topic><topic>Ischemic Attack, Transient - etiology</topic><topic>Ischemic Attack, Transient - mortality</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular and cellular biology</topic><topic>Platelet Activation</topic><topic>Platelet Aggregation</topic><topic>Platelet diseases and coagulopathies</topic><topic>Platelet Function Tests</topic><topic>Platelets and Blood Cells</topic><topic>Predictive Value of Tests</topic><topic>Recurrence</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Severity of Illness Index</topic><topic>Stroke</topic><topic>Stroke - blood</topic><topic>Stroke - diagnosis</topic><topic>Stroke - etiology</topic><topic>Stroke - mortality</topic><topic>Time Factors</topic><topic>Transient ischemic attack</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fateh-Moghadam, Suzanne</creatorcontrib><creatorcontrib>Htun, Patrik</creatorcontrib><creatorcontrib>Tomandl, Bernd</creatorcontrib><creatorcontrib>Sander, Dirk</creatorcontrib><creatorcontrib>Stellos, Konstantinos</creatorcontrib><creatorcontrib>Geisler, Tobias</creatorcontrib><creatorcontrib>Langer, Harald</creatorcontrib><creatorcontrib>Walton, Kodwo</creatorcontrib><creatorcontrib>Handschu, Rene</creatorcontrib><creatorcontrib>Garlichs, Christoph</creatorcontrib><creatorcontrib>Daniel, Werner G.</creatorcontrib><creatorcontrib>Gawaz, Meinrad</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fateh-Moghadam, Suzanne</au><au>Htun, Patrik</au><au>Tomandl, Bernd</au><au>Sander, Dirk</au><au>Stellos, Konstantinos</au><au>Geisler, Tobias</au><au>Langer, Harald</au><au>Walton, Kodwo</au><au>Handschu, Rene</au><au>Garlichs, Christoph</au><au>Daniel, Werner G.</au><au>Gawaz, Meinrad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperresponsiveness of platelets in ischemic stroke</atitle><jtitle>Thrombosis and haemostasis</jtitle><addtitle>Thromb Haemost</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>97</volume><issue>6</issue><spage>974</spage><epage>978</epage><pages>974-978</pages><issn>0340-6245</issn><eissn>2567-689X</eissn><coden>THHADQ</coden><abstract>Summary
Platelet activation and aggregation are critical in the pathogenesis of acute ischemic cerebrovascular diseases. The aim of our study was to characterize platelet function in patients with acute ischemic stroke or transient ischemic attack (TIA), and to evaluate the effect of platelet activation on clinical outcome. One hundred thirty-eight consecutive patients with TIA (n=74) or stroke (n=64) were enrolled in this study. Platelet aggregation in response to ADP, epinephrine, arachidonic acid, or collagen, and expression of platelet activation receptors (CD62P, CD63, LIBS-1 and PAC-1) in the acute phase and at three months follow-up were evaluated. Platelets derived from stroke patients were more hyperaggregable in response to agonists in the acute phase compared to TIA patients (p[ADP]=0.002, p[arachidonic acid]=0.047, p[epinephrine]=0.020). Platelet activation was enhanced in the acute phase irrespective of the severity of the disease (stroke or TIA) and returned to baseline levels three months later. Persistent elevated platelet activation at three months follow-up (PAC-1) was associated with increased incidence of recurrent stroke (median, [interquartile range] 3.4, [3.0–5.2] versus 2.9, [2.3–4.0], p=0.048). In conclusion, platelets are hyperactive in acute stroke compared with TIA. A more intensified dual antiplatelet therapy may be of benefit for stroke patients.</abstract><cop>Stuttgart</cop><pub>Schattauer Verlag für Medizin und Naturwissenschaften</pub><pmid>17549300</pmid><doi>10.1160/th06-12-0725</doi><tpages>5</tpages></addata></record> |
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| ispartof | Thrombosis and haemostasis, 2007-06, Vol.97 (6), p.974-978 |
| issn | 0340-6245 2567-689X |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adenosine Diphosphate - metabolism Adult Aged Arachidonic Acid - metabolism Biological and medical sciences Biomarkers - blood Blood coagulation. Blood cells Blood Platelets - metabolism Brain Ischemia - blood Brain Ischemia - complications Brain Ischemia - mortality Collagen - metabolism Epinephrine - metabolism Female flow cytometry Follow-Up Studies Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Humans Ischemic Attack, Transient - blood Ischemic Attack, Transient - diagnosis Ischemic Attack, Transient - etiology Ischemic Attack, Transient - mortality Logistic Models Male Medical sciences Middle Aged Molecular and cellular biology Platelet Activation Platelet Aggregation Platelet diseases and coagulopathies Platelet Function Tests Platelets and Blood Cells Predictive Value of Tests Recurrence Risk Assessment Risk Factors ROC Curve Severity of Illness Index Stroke Stroke - blood Stroke - diagnosis Stroke - etiology Stroke - mortality Time Factors Transient ischemic attack |
| title | Hyperresponsiveness of platelets in ischemic stroke |
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