Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage
Summary From 1998 to 2003, 133 Caucasian women aged 17–40 years (median 29 years) suffering from unexplained recurrent miscarriage (uRM) were consecutively enrolled. In patients and 133 age-matched healthy controls prothrombotic risk factors (factor V (FV) G1691A, factor II (FII) G20210A, MTHFR T677...
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| Veröffentlicht in: | Thrombosis and haemostasis 2005, Vol.93 (5), p.867-871 |
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| creator | Krause, Manuela Sonntag, Barbara Klamroth, Robert Heinecke, Achim Scholz, Carola Langer, Claus Scharrer, Inge Greb, Robert R. von Eckardstein, Arnold Nowak-Göttl, Ulrike |
| description | Summary
From 1998 to 2003, 133 Caucasian women aged 17–40 years (median 29 years) suffering from unexplained recurrent miscarriage (uRM) were consecutively enrolled. In patients and 133 age-matched healthy controls prothrombotic risk factors (factor V (FV) G1691A, factor II (FII) G20210A, MTHFR T677T, 4G/5G plasminogen activator inhibitor (PAI)-1, lipoprotein (Lp) (a), protein C (PC), protein S (PS), antithrombin (AT), antiphospholipid/anticardiolipin (APA/ACA) antibodies) as well as associated environmental conditions (smoking and obesity) were investigated. 70 (52.6%) of the patients had at least one prothrombotic risk factor compared with 26 control women (19.5%; p 30 mg/dL, increased APA/ACA and BMI > 25 kg/m
2
in combination with a prothrombotic risk factor were found to be significantly associated with uRM. In multivariate analysis, increased Lp(a) (odds ratio (OR): 4.7/95% confidence interval (CI): 2.0–10.7), the FV mutation (OR:3.8/CI:1.4–10.7), and increased APA/ACA (OR: 4.5/CI: 1.1–17.7) had independent associations with uRM. |
| doi_str_mv | 10.1160/TH04-08-0519 |
| format | Article |
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From 1998 to 2003, 133 Caucasian women aged 17–40 years (median 29 years) suffering from unexplained recurrent miscarriage (uRM) were consecutively enrolled. In patients and 133 age-matched healthy controls prothrombotic risk factors (factor V (FV) G1691A, factor II (FII) G20210A, MTHFR T677T, 4G/5G plasminogen activator inhibitor (PAI)-1, lipoprotein (Lp) (a), protein C (PC), protein S (PS), antithrombin (AT), antiphospholipid/anticardiolipin (APA/ACA) antibodies) as well as associated environmental conditions (smoking and obesity) were investigated. 70 (52.6%) of the patients had at least one prothrombotic risk factor compared with 26 control women (19.5%; p<0.0001). Body mass index (BMI; p=0.78) and smoking habits (p=0.44) did not differ significantly between the groups investigated. Upon univariate analysis the heterozygous FV mutation, Lp(a) > 30 mg/dL, increased APA/ACA and BMI > 25 kg/m
2
in combination with a prothrombotic risk factor were found to be significantly associated with uRM. In multivariate analysis, increased Lp(a) (odds ratio (OR): 4.7/95% confidence interval (CI): 2.0–10.7), the FV mutation (OR:3.8/CI:1.4–10.7), and increased APA/ACA (OR: 4.5/CI: 1.1–17.7) had independent associations with uRM.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1160/TH04-08-0519</identifier><language>eng</language><publisher>Schattauer GmbH</publisher><subject>Blood Coagulation, Fibrinolysis and Cellular Haemostasis</subject><ispartof>Thrombosis and haemostasis, 2005, Vol.93 (5), p.867-871</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c799-d449005ce7e3d746ed0208f6c5434bf64d370e2dfab5f1e1e7b8bb02f0751c613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH04-08-0519.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1160/TH04-08-0519$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3005,4010,27900,27901,27902,54534,54535</link.rule.ids></links><search><creatorcontrib>Krause, Manuela</creatorcontrib><creatorcontrib>Sonntag, Barbara</creatorcontrib><creatorcontrib>Klamroth, Robert</creatorcontrib><creatorcontrib>Heinecke, Achim</creatorcontrib><creatorcontrib>Scholz, Carola</creatorcontrib><creatorcontrib>Langer, Claus</creatorcontrib><creatorcontrib>Scharrer, Inge</creatorcontrib><creatorcontrib>Greb, Robert R.</creatorcontrib><creatorcontrib>von Eckardstein, Arnold</creatorcontrib><creatorcontrib>Nowak-Göttl, Ulrike</creatorcontrib><title>Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage</title><title>Thrombosis and haemostasis</title><addtitle>Thromb Haemost</addtitle><description>Summary
From 1998 to 2003, 133 Caucasian women aged 17–40 years (median 29 years) suffering from unexplained recurrent miscarriage (uRM) were consecutively enrolled. In patients and 133 age-matched healthy controls prothrombotic risk factors (factor V (FV) G1691A, factor II (FII) G20210A, MTHFR T677T, 4G/5G plasminogen activator inhibitor (PAI)-1, lipoprotein (Lp) (a), protein C (PC), protein S (PS), antithrombin (AT), antiphospholipid/anticardiolipin (APA/ACA) antibodies) as well as associated environmental conditions (smoking and obesity) were investigated. 70 (52.6%) of the patients had at least one prothrombotic risk factor compared with 26 control women (19.5%; p<0.0001). Body mass index (BMI; p=0.78) and smoking habits (p=0.44) did not differ significantly between the groups investigated. Upon univariate analysis the heterozygous FV mutation, Lp(a) > 30 mg/dL, increased APA/ACA and BMI > 25 kg/m
2
in combination with a prothrombotic risk factor were found to be significantly associated with uRM. In multivariate analysis, increased Lp(a) (odds ratio (OR): 4.7/95% confidence interval (CI): 2.0–10.7), the FV mutation (OR:3.8/CI:1.4–10.7), and increased APA/ACA (OR: 4.5/CI: 1.1–17.7) had independent associations with uRM.</description><subject>Blood Coagulation, Fibrinolysis and Cellular Haemostasis</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNotkE1LxDAYhIMouK7e_AE5KhJ90-ajPcriusKClz14K2n6xmbdJkvSoj_fLXqZgWGYgYeQWw6PnCt42m1AMKgYSF6fkUUhlWaqqj_OyQJKAUwVQl6Sq5z3AFyJWi5I2PpjPKY4og_0ztxTEzoaxx4TndM-xaGNo7c0-fxFnbFjTJmeuiszWZO9CfQ7DnhSP_Z0CvhzPBgfsKMJ7ZQShpEOPluTkjefeE0unDlkvPn3JdmtX3arDdu-v76tnrfM6rpmnRA1gLSosey0UNhBAZVTVopStE6JrtSARedMKx1Hjrqt2hYKB1pyq3i5JA9_s2PvccBmH6cUTn8Nh2Ym1cykGqiamVT5C5QlXes</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Krause, Manuela</creator><creator>Sonntag, Barbara</creator><creator>Klamroth, Robert</creator><creator>Heinecke, Achim</creator><creator>Scholz, Carola</creator><creator>Langer, Claus</creator><creator>Scharrer, Inge</creator><creator>Greb, Robert R.</creator><creator>von Eckardstein, Arnold</creator><creator>Nowak-Göttl, Ulrike</creator><general>Schattauer GmbH</general><scope/></search><sort><creationdate>2005</creationdate><title>Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage</title><author>Krause, Manuela ; Sonntag, Barbara ; Klamroth, Robert ; Heinecke, Achim ; Scholz, Carola ; Langer, Claus ; Scharrer, Inge ; Greb, Robert R. ; von Eckardstein, Arnold ; Nowak-Göttl, Ulrike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c799-d449005ce7e3d746ed0208f6c5434bf64d370e2dfab5f1e1e7b8bb02f0751c613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Blood Coagulation, Fibrinolysis and Cellular Haemostasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krause, Manuela</creatorcontrib><creatorcontrib>Sonntag, Barbara</creatorcontrib><creatorcontrib>Klamroth, Robert</creatorcontrib><creatorcontrib>Heinecke, Achim</creatorcontrib><creatorcontrib>Scholz, Carola</creatorcontrib><creatorcontrib>Langer, Claus</creatorcontrib><creatorcontrib>Scharrer, Inge</creatorcontrib><creatorcontrib>Greb, Robert R.</creatorcontrib><creatorcontrib>von Eckardstein, Arnold</creatorcontrib><creatorcontrib>Nowak-Göttl, Ulrike</creatorcontrib><jtitle>Thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krause, Manuela</au><au>Sonntag, Barbara</au><au>Klamroth, Robert</au><au>Heinecke, Achim</au><au>Scholz, Carola</au><au>Langer, Claus</au><au>Scharrer, Inge</au><au>Greb, Robert R.</au><au>von Eckardstein, Arnold</au><au>Nowak-Göttl, Ulrike</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage</atitle><jtitle>Thrombosis and haemostasis</jtitle><addtitle>Thromb Haemost</addtitle><date>2005</date><risdate>2005</risdate><volume>93</volume><issue>5</issue><spage>867</spage><epage>871</epage><pages>867-871</pages><issn>0340-6245</issn><eissn>2567-689X</eissn><abstract>Summary
From 1998 to 2003, 133 Caucasian women aged 17–40 years (median 29 years) suffering from unexplained recurrent miscarriage (uRM) were consecutively enrolled. In patients and 133 age-matched healthy controls prothrombotic risk factors (factor V (FV) G1691A, factor II (FII) G20210A, MTHFR T677T, 4G/5G plasminogen activator inhibitor (PAI)-1, lipoprotein (Lp) (a), protein C (PC), protein S (PS), antithrombin (AT), antiphospholipid/anticardiolipin (APA/ACA) antibodies) as well as associated environmental conditions (smoking and obesity) were investigated. 70 (52.6%) of the patients had at least one prothrombotic risk factor compared with 26 control women (19.5%; p<0.0001). Body mass index (BMI; p=0.78) and smoking habits (p=0.44) did not differ significantly between the groups investigated. Upon univariate analysis the heterozygous FV mutation, Lp(a) > 30 mg/dL, increased APA/ACA and BMI > 25 kg/m
2
in combination with a prothrombotic risk factor were found to be significantly associated with uRM. In multivariate analysis, increased Lp(a) (odds ratio (OR): 4.7/95% confidence interval (CI): 2.0–10.7), the FV mutation (OR:3.8/CI:1.4–10.7), and increased APA/ACA (OR: 4.5/CI: 1.1–17.7) had independent associations with uRM.</abstract><pub>Schattauer GmbH</pub><doi>10.1160/TH04-08-0519</doi><tpages>5</tpages></addata></record> |
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| subjects | Blood Coagulation, Fibrinolysis and Cellular Haemostasis |
| title | Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage |
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