A role for p38 MAP kinase in platelet activation by von Willebrand Factor

Summary Platelet activation induced by von Willebrand factor (VWF) binding to the membrane GPIb-IX-V receptor involves multiple signal transduction pathways. Among these, recruitment and activation of the FcγRIIA and stimulation of phospholipase A 2 represent independent events equally essential to...

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Veröffentlicht in:	Thrombosis and haemostasis 2004-01, Vol.91 (1), p.102-110
Hauptverfasser:	Canobbio, Ilaria, Reineri, Stefania, Sinigaglia, Fabiola, Balduini, Cesare, Torti, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Antigens, CD - metabolism Arachidonic Acid - metabolism Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism Cyclooxygenase Inhibitors - pharmacology Electrophoresis, Polyacrylamide Gel Enzyme Activation Enzyme Precursors - metabolism Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Humans Imidazoles - pharmacology Intracellular Signaling Peptides and Proteins Medical sciences Mitogen-Activated Protein Kinases - physiology Molecular and cellular biology p38 Mitogen-Activated Protein Kinases Phospholipases A - metabolism Phospholipases A2 Phosphorylation Platelet Activation Platelet diseases and coagulopathies Platelet Glycoprotein GPIb-IX Complex - metabolism Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Platelet Membrane Glycoproteins Platelets and Blood Cells Protein-Tyrosine Kinases - metabolism Pyridines - pharmacology Receptors, IgG - metabolism Ristocetin - pharmacology Signal Transduction Syk Kinase Thromboxane A2 - metabolism Time Factors von Willebrand Factor - metabolism
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