Anti-heavy-chain monoclonal antibodies directed to the acidic regions of the factor VIII molecule inhibit the binding of factor VIII to phospholipids and von Willebrand factor

Summary Recent studies have shown that inhibitors develop against acidic regions of the FVIII molecule, which contain important functional sites. However, their mechanisms of inhibition are not well understood. In this study, two anti-human FVIII mouse monoclonal antibodies (MAbs), directed towards...

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Veröffentlicht in:	Thrombosis and haemostasis 2003-09, Vol.90 (3), p.385-397
Hauptverfasser:	Raut, Sanjeev, Villard, Sylvie, Grailly, Sabrina, Gilles, Jean-Guy G., Granier, Claude, Saint-Remy, Jean-Marie R., Barrowcliffe, Trevor W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids, Acidic Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Blood Coagulation, Fibrinolysis and Cellular Haemostasis Epitope Mapping Epitopes Factor VIII - immunology Factor VIII - metabolism Factor Xa - biosynthesis Hematologic and hematopoietic diseases Humans Inhibitory Concentration 50 Medical sciences Mice Phospholipids - metabolism Platelet diseases and coagulopathies Protein Binding - drug effects Thrombin - metabolism von Willebrand Factor - metabolism
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