Mitogenic and Complement Activating Activities of the Herbal Components of Juzen-Taiho-To1

Mitogenic and Complement Activating Activities of the Herbal Components of Juzen-Taiho-To1

Abstract The Kampo (Japanese herbal) medicine “Juzen-Taiho-To” (TJ-48), which was prepared by decocting a concoction (formula), contains ten kinds of herbs and has several immunostimulating activities. In order to determine the contribution of each herbal component, the complement-activating and mit...

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Veröffentlicht in:Planta medica 1992-04, Vol.58 (2), p.166-170
Hauptverfasser: Yamada, Haruki, Kiyohara, Hiroaki, Takemoto, Norito, Zhao, Ji-Fu, Kawamura, Hideki, Komatsu, Yasuhiro, Cyong, Jong-Chol, Aburada, Masaki, Hosoya, Eikichi
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container_end_page 170
container_issue 2
container_start_page 166
container_title Planta medica
container_volume 58
creator Yamada, Haruki
Kiyohara, Hiroaki
Takemoto, Norito
Zhao, Ji-Fu
Kawamura, Hideki
Komatsu, Yasuhiro
Cyong, Jong-Chol
Aburada, Masaki
Hosoya, Eikichi
description Abstract The Kampo (Japanese herbal) medicine “Juzen-Taiho-To” (TJ-48), which was prepared by decocting a concoction (formula), contains ten kinds of herbs and has several immunostimulating activities. In order to determine the contribution of each herbal component, the complement-activating and mitogenic activities of the hot water extract as well as the polysaccharide fraction from each herb were tested. Hot water extracts of Glycyrrhizae radix, Astragali radix, and Atractylodis lanceae rhizoma showed significant mitogenic activity whereas that of Cinnamomi cortex showed potent complement-activating activity. However, the exclusion of any single component herb whether active or not on its own did not result in a loss or an increase of the overall activity of TJ-48. The polysaccharide fraction from Glycyrrhizae radix showed the most potent of both activities among the same fractions from the other nine herbs, and reduced both activities after periodate oxidation, thus indicating that the carbohydrate moiety may contribute to both activities.
doi_str_mv 10.1055/s-2006-961421
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