Dianhydrohexitole-Based Benzamidines: An Efficient Synthesis of New Factor Xa Inhibitors

ABSTRACT Dianhydrohexitole-based benzamidines were synthesised as potential factor Xa inhibitors. The key steps for the synthesis of a bis-benzamidine series were nucleophilic aromatic substitutions and Mitsunobu reactions to introduce substituted phenyl ether moieties. Mono-benzamidines with an ORT...

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Veröffentlicht in:	Synthesis (Stuttgart) 2004-06, Vol.2004 (8), p.1211-1228
Hauptverfasser:	Vogler, Marko, Koert, Ulrich, Harms, Klaus, Dorsch, Dieter, Gleitz, Johannes, Raddatz, Peter
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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