Rho-kinase Is Involved in the Sustained Phosphorylation of Myosin and the Irreversible Platelet Aggregation Induced by PAR1 Activating Peptide

Summary We have addressed the role of Rho-kinase in the different steps of thrombin receptor agonist peptide (TRAP) -induced platelet activation. Interestingly, under physiological conditions, incubation of platelets with increasing concentrations of the specific Rho-kinase inhibitor Y-27632 resulte...

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Veröffentlicht in:	Thrombosis and haemostasis 2001-03, Vol.85 (3), p.514-20
Hauptverfasser:	Missy, K., Plantavid, M., Pacaud, P., Viala, C., Chap, H., Payrastre, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adenosine Diphosphate - secretion Amides - pharmacology Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - cytology Blood Platelets - drug effects Cytoskeleton - drug effects Cytoskeleton - metabolism Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Humans Intracellular Signaling Peptides and Proteins Kinetics Molecular and cellular biology Myosins - drug effects Myosins - metabolism Peptide Fragments - pharmacology Phosphorylation Platelet Platelet Aggregation - drug effects Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Pyridines - pharmacology Review Article rho-Associated Kinases
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