Anticoagulant Activity and Pharmacokinetic Properties of a Sub-cutaneously Administered Mixed Micellar Formulation of Argatroban in Experimental Animals

Summary We have studied the anticoagulant properties of a novel mixed micellar formulation containing 14 mg/ml argatroban administered by the sub-cutaneous (s. c.) route to rats, rabbits, dogs and primates. Blood samples were taken at various times post-treatment for the determination of the thrombi...

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Veröffentlicht in:	Thrombosis and haemostasis 2000-08, Vol.84 (2), p.278-285
Hauptverfasser:	Berry, Christopher N., Lunven, Catherine, Lecoffre, Catherine, Lainée, Pierre, O’Connor, Stephen E., André, Frédéric, Roger, Bénédicte, Garrigou-Gadenne, Danielle, Rouchouse, Alain, Roome, Nigel O., Vivan, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants - pharmacokinetics Anticoagulants - pharmacology Antithrombins - administration & dosage Antithrombins - pharmacokinetics Antithrombins - pharmacology Biological and medical sciences Blood Coagulation Tests Blood. Blood coagulation. Reticuloendothelial system Dogs Dose-Response Relationship, Drug Drug Compounding - methods Drug Compounding - standards Drug Evaluation, Preclinical Female Half-Life Injections, Subcutaneous Macaca Male Medical sciences Micelles Pharmacology. Drug treatments Pipecolic Acids - administration & dosage Pipecolic Acids - blood Pipecolic Acids - pharmacokinetics Pipecolic Acids - pharmacology Rabbits Rats Review Article Solubility Time Factors
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