The Influence of (R)- and (S)-Warfarin, Vitamin K and Vitamin K Epoxide upon Warfarin Anticoagulation
Summary The contribution of (R)and (S)-warfarin enantiomers, vitamin K and vitamin K epoxide and patient factors to inter-individual variability in daily warfarin requirements were examined in a group of 73 patients. Simple correlation analysis showed a significant positive relationship between INR...
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| Veröffentlicht in: | Thrombosis and haemostasis 2000-07, Vol.84 (1), p.39-42 |
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| creator | Kamali, Farhad Edwards, Clive Butler, Timothy J. Wynne, Hilary A. |
| description | Summary
The contribution of (R)and (S)-warfarin enantiomers, vitamin K and vitamin K epoxide and patient factors to inter-individual variability in daily warfarin requirements were examined in a group of 73 patients. Simple correlation analysis showed a significant positive relationship between INR values and plasma (S)-warfarin concentrations (r = 0.25; p = 0.038). Multivariate analysis for relationships with INR demonstrated a highly significant positive relationship between INR and (S)- warfarin (p = 0.004) and plasma vitamin K epoxide concentrations (p = 0.028), and a significant negative relationship between INR and plasma vitamin K concentrations (p = 0.034). Twenty five percent of variation in INR could be explained by these variables (adjusted R
2
= 0.25). Correlation analysis of data showed that warfarin dosage was significantly and negatively correlated with patient age (r = −0.42; p |
| doi_str_mv | 10.1055/s-0037-1613964 |
| format | Article |
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The contribution of (R)and (S)-warfarin enantiomers, vitamin K and vitamin K epoxide and patient factors to inter-individual variability in daily warfarin requirements were examined in a group of 73 patients. Simple correlation analysis showed a significant positive relationship between INR values and plasma (S)-warfarin concentrations (r = 0.25; p = 0.038). Multivariate analysis for relationships with INR demonstrated a highly significant positive relationship between INR and (S)- warfarin (p = 0.004) and plasma vitamin K epoxide concentrations (p = 0.028), and a significant negative relationship between INR and plasma vitamin K concentrations (p = 0.034). Twenty five percent of variation in INR could be explained by these variables (adjusted R
2
= 0.25). Correlation analysis of data showed that warfarin dosage was significantly and negatively correlated with patient age (r = −0.42; p <0.0001). Patient age accounted for 25% of variation in warfarin dosage requirements (R
2
= 0.25). The combined effects of age and vitamin K appear to account for much of the inter-individual variability in warfarin dosage requirements.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1055/s-0037-1613964</identifier><identifier>PMID: 10928467</identifier><identifier>CODEN: THHADQ</identifier><language>eng</language><publisher>Stuttgart: Schattauer Verlag für Medizin und Naturwissenschaften</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Anticoagulants - administration & dosage ; Anticoagulants - blood ; Anticoagulants - chemistry ; Anticoagulants - pharmacokinetics ; Anticoagulants - therapeutic use ; Biological and medical sciences ; Blood Coagulation - drug effects ; Blood Coagulation Factors - metabolism ; Blood. Blood coagulation. Reticuloendothelial system ; Commentary ; Drug Resistance ; Female ; Genetic Variation ; Humans ; International Normalized Ratio ; Liver - metabolism ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Pharmacology. Drug treatments ; Stereoisomerism ; Vitamin K - blood ; Vitamin K 1 - analogs & derivatives ; Vitamin K 1 - blood ; Warfarin - administration & dosage ; Warfarin - blood ; Warfarin - chemistry ; Warfarin - pharmacokinetics ; Warfarin - therapeutic use</subject><ispartof>Thrombosis and haemostasis, 2000-07, Vol.84 (1), p.39-42</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-4e01e67c366f5b5b367d1f4922d53ecffd0a25ed9ea5e74106ee2ba2f367df2d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1613964.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0037-1613964$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3017,3018,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1444272$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10928467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamali, Farhad</creatorcontrib><creatorcontrib>Edwards, Clive</creatorcontrib><creatorcontrib>Butler, Timothy J.</creatorcontrib><creatorcontrib>Wynne, Hilary A.</creatorcontrib><title>The Influence of (R)- and (S)-Warfarin, Vitamin K and Vitamin K Epoxide upon Warfarin Anticoagulation</title><title>Thrombosis and haemostasis</title><addtitle>Thromb Haemost</addtitle><description>Summary
The contribution of (R)and (S)-warfarin enantiomers, vitamin K and vitamin K epoxide and patient factors to inter-individual variability in daily warfarin requirements were examined in a group of 73 patients. Simple correlation analysis showed a significant positive relationship between INR values and plasma (S)-warfarin concentrations (r = 0.25; p = 0.038). Multivariate analysis for relationships with INR demonstrated a highly significant positive relationship between INR and (S)- warfarin (p = 0.004) and plasma vitamin K epoxide concentrations (p = 0.028), and a significant negative relationship between INR and plasma vitamin K concentrations (p = 0.034). Twenty five percent of variation in INR could be explained by these variables (adjusted R
2
= 0.25). Correlation analysis of data showed that warfarin dosage was significantly and negatively correlated with patient age (r = −0.42; p <0.0001). Patient age accounted for 25% of variation in warfarin dosage requirements (R
2
= 0.25). The combined effects of age and vitamin K appear to account for much of the inter-individual variability in warfarin dosage requirements.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anticoagulants - administration & dosage</subject><subject>Anticoagulants - blood</subject><subject>Anticoagulants - chemistry</subject><subject>Anticoagulants - pharmacokinetics</subject><subject>Anticoagulants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation - drug effects</subject><subject>Blood Coagulation Factors - metabolism</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Commentary</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>Genetic Variation</subject><subject>Humans</subject><subject>International Normalized Ratio</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Pharmacology. Drug treatments</subject><subject>Stereoisomerism</subject><subject>Vitamin K - blood</subject><subject>Vitamin K 1 - analogs & derivatives</subject><subject>Vitamin K 1 - blood</subject><subject>Warfarin - administration & dosage</subject><subject>Warfarin - blood</subject><subject>Warfarin - chemistry</subject><subject>Warfarin - pharmacokinetics</subject><subject>Warfarin - therapeutic use</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqtkU2L1TAUhosoznV061K6EJkBOyZpkrbLYRh1cEDQ8WMXzk1PbIY2qfnw49_ba6-OCO5chcN58r7wnKJ4SMkJJUI8ixUhdVNRSetO8lvFhgnZVLLtPt4uNqTmpJKMi4PiXozXhFDJO3G3OKCkYy2XzabAqwHLC2fGjE5j6U159Oa4KsH15dHb4-oDBAPBuqfle5tgsq589XN3M53P_pvtscyzd-UvvDx1yWoPn_IIyXp3v7hjYIz4YP8eFu-en1-dvawuX7-4ODu9rLTgbao4Eoqy0bWURmzFtpZNTw3vGOtFjdqYngAT2HcIAhtOiURkW2BmBxrW14fFkzV3Dv5zxpjUZKPGcQSHPkfVUNa0lIkFPFlBHXyMAY2ag50gfFeUqJ1YFdVOrNqLXT482ifn7YT9H_hqcgEe7wGIGkYTwGkbbzjOOWvYglUrlgaLE6prn4NblPy7V6981AOkBBnD78w0BD9tfVxqlpuoAXDyMcFu1t4ldGlZBD3YL6hsjBlVnFFbGNUELkcd7JwU47JdWux_bGnb5u8GFQf_VQ1pGusfJ-feYw</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Kamali, Farhad</creator><creator>Edwards, Clive</creator><creator>Butler, Timothy J.</creator><creator>Wynne, Hilary A.</creator><general>Schattauer Verlag für Medizin und Naturwissenschaften</general><general>Schattauer GmbH</general><general>Schattauer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000701</creationdate><title>The Influence of (R)- and (S)-Warfarin, Vitamin K and Vitamin K Epoxide upon Warfarin Anticoagulation</title><author>Kamali, Farhad ; Edwards, Clive ; Butler, Timothy J. ; Wynne, Hilary A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-4e01e67c366f5b5b367d1f4922d53ecffd0a25ed9ea5e74106ee2ba2f367df2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anticoagulants - administration & dosage</topic><topic>Anticoagulants - blood</topic><topic>Anticoagulants - chemistry</topic><topic>Anticoagulants - pharmacokinetics</topic><topic>Anticoagulants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation - drug effects</topic><topic>Blood Coagulation Factors - metabolism</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Commentary</topic><topic>Drug Resistance</topic><topic>Female</topic><topic>Genetic Variation</topic><topic>Humans</topic><topic>International Normalized Ratio</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Pharmacology. Drug treatments</topic><topic>Stereoisomerism</topic><topic>Vitamin K - blood</topic><topic>Vitamin K 1 - analogs & derivatives</topic><topic>Vitamin K 1 - blood</topic><topic>Warfarin - administration & dosage</topic><topic>Warfarin - blood</topic><topic>Warfarin - chemistry</topic><topic>Warfarin - pharmacokinetics</topic><topic>Warfarin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamali, Farhad</creatorcontrib><creatorcontrib>Edwards, Clive</creatorcontrib><creatorcontrib>Butler, Timothy J.</creatorcontrib><creatorcontrib>Wynne, Hilary A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamali, Farhad</au><au>Edwards, Clive</au><au>Butler, Timothy J.</au><au>Wynne, Hilary A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Influence of (R)- and (S)-Warfarin, Vitamin K and Vitamin K Epoxide upon Warfarin Anticoagulation</atitle><jtitle>Thrombosis and haemostasis</jtitle><addtitle>Thromb Haemost</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>84</volume><issue>1</issue><spage>39</spage><epage>42</epage><pages>39-42</pages><issn>0340-6245</issn><eissn>2567-689X</eissn><coden>THHADQ</coden><abstract>Summary
The contribution of (R)and (S)-warfarin enantiomers, vitamin K and vitamin K epoxide and patient factors to inter-individual variability in daily warfarin requirements were examined in a group of 73 patients. Simple correlation analysis showed a significant positive relationship between INR values and plasma (S)-warfarin concentrations (r = 0.25; p = 0.038). Multivariate analysis for relationships with INR demonstrated a highly significant positive relationship between INR and (S)- warfarin (p = 0.004) and plasma vitamin K epoxide concentrations (p = 0.028), and a significant negative relationship between INR and plasma vitamin K concentrations (p = 0.034). Twenty five percent of variation in INR could be explained by these variables (adjusted R
2
= 0.25). Correlation analysis of data showed that warfarin dosage was significantly and negatively correlated with patient age (r = −0.42; p <0.0001). Patient age accounted for 25% of variation in warfarin dosage requirements (R
2
= 0.25). The combined effects of age and vitamin K appear to account for much of the inter-individual variability in warfarin dosage requirements.</abstract><cop>Stuttgart</cop><pub>Schattauer Verlag für Medizin und Naturwissenschaften</pub><pmid>10928467</pmid><doi>10.1055/s-0037-1613964</doi><tpages>4</tpages></addata></record> |
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| ispartof | Thrombosis and haemostasis, 2000-07, Vol.84 (1), p.39-42 |
| issn | 0340-6245 2567-689X |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Age Factors Aged Aged, 80 and over Anticoagulants - administration & dosage Anticoagulants - blood Anticoagulants - chemistry Anticoagulants - pharmacokinetics Anticoagulants - therapeutic use Biological and medical sciences Blood Coagulation - drug effects Blood Coagulation Factors - metabolism Blood. Blood coagulation. Reticuloendothelial system Commentary Drug Resistance Female Genetic Variation Humans International Normalized Ratio Liver - metabolism Male Medical sciences Middle Aged Multivariate Analysis Pharmacology. Drug treatments Stereoisomerism Vitamin K - blood Vitamin K 1 - analogs & derivatives Vitamin K 1 - blood Warfarin - administration & dosage Warfarin - blood Warfarin - chemistry Warfarin - pharmacokinetics Warfarin - therapeutic use |
| title | The Influence of (R)- and (S)-Warfarin, Vitamin K and Vitamin K Epoxide upon Warfarin Anticoagulation |
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