CYP2B6 and ABCB1 genotypes predict methadone plasma exposure among patients on maintenance therapy against opioid addictions in Tanzania

Aims Methadone maintenance therapy (MMT) exhibits significant variability in pharmacokinetics and clinical response, partly due to genetic variations. However, data from sub‐Saharan African populations are lacking. We examined plasma methadone variability and pharmacogenetic influences among opioid‐...

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Veröffentlicht in:	British journal of clinical pharmacology 2024-11, Vol.90 (11), p.2823-2836
Hauptverfasser:	Mugusi, Sabina, Mnkugwe, Rajabu Hussein, Sanga, Anna A., Salahuddin, Azreen, Barclay, Victoria, Shayo, Grace, Dahl, Marja‐Liisa, Aklillu, Eleni
Format:	Artikel
Sprache:	eng
Schlagworte:	addiction treatment CYP2B6 genotype Medicin och hälsovetenskap methadone maintenance therapy opioid use Tanzania
Online-Zugang:	Volltext
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