The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals
Abstract Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts and an additional 65,986 European-ancestry individu...
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| Veröffentlicht in: | G3 : genes - genomes - genetics 2024-08, Vol.14 (8) |
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| creator | Gong, Tong Karlsson, Robert Yao, Shuyang Magnusson, Patrik K E Ajnakina, Olesya Steptoe, Andrew Bhatta, Laxmi Brumpton, Ben Kumar, Ashish Mélen, Erik Lin, Keng-Han Tian, Chao Fall, Tove Almqvist, Catarina |
| description | Abstract
Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts and an additional 65,986 European-ancestry individuals in 3 replication cohorts from Sweden, Norway, and the United Kingdom. Association tests with >7.4 million single-nucleotide polymorphisms were meta-analyzed using a fixed effect model after controlling for population structure and relatedness. We identified 2 suggestive loci using discovery cohorts, which did not reach genome-wide significance after meta-analysis with replication cohorts. Single-nucleotide polymorphism-based heritability of dog ownership using linkage disequilibrium score regression was estimated at 0.123 (CI 0.038–0.207) using the discovery cohorts and 0.018 (CI −0.002 to 0.039) when adding in replication cohorts. Negative genetic correlation with complex traits including type 2 diabetes, depression, neuroticism, and asthma was only found using discovery summary data. Furthermore, we did not identify any genes/gene-sets reaching even a suggestive level of significance. This genome-wide association study does not, by itself, provide clear evidence on common genetic variants that influence dog ownership among European-ancestry individuals. |
| doi_str_mv | 10.1093/g3journal/jkae116 |
| format | Article |
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Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts and an additional 65,986 European-ancestry individuals in 3 replication cohorts from Sweden, Norway, and the United Kingdom. Association tests with >7.4 million single-nucleotide polymorphisms were meta-analyzed using a fixed effect model after controlling for population structure and relatedness. We identified 2 suggestive loci using discovery cohorts, which did not reach genome-wide significance after meta-analysis with replication cohorts. Single-nucleotide polymorphism-based heritability of dog ownership using linkage disequilibrium score regression was estimated at 0.123 (CI 0.038–0.207) using the discovery cohorts and 0.018 (CI −0.002 to 0.039) when adding in replication cohorts. Negative genetic correlation with complex traits including type 2 diabetes, depression, neuroticism, and asthma was only found using discovery summary data. Furthermore, we did not identify any genes/gene-sets reaching even a suggestive level of significance. This genome-wide association study does not, by itself, provide clear evidence on common genetic variants that influence dog ownership among European-ancestry individuals.</description><identifier>ISSN: 2160-1836</identifier><identifier>EISSN: 2160-1836</identifier><identifier>DOI: 10.1093/g3journal/jkae116</identifier><identifier>PMID: 38820132</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Animals ; dog ownership ; Dogs ; European ancestry ; Female ; Genome-Wide Association Study ; GWAS ; heritability ; Humans ; Investigation ; Linkage Disequilibrium ; Male ; Ownership ; Polymorphism, Single Nucleotide ; replication ; White People - genetics</subject><ispartof>G3 : genes - genomes - genetics, 2024-08, Vol.14 (8)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America. 2024</rights><rights>The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c394t-bf8230121a5ff94a40730b9c83c6d85a14c9a9e21f8ee2337b423219145391de3</cites><orcidid>0000-0003-3987-1236 ; 0000-0002-1045-1898 ; 0000-0002-8949-2587 ; 0000-0002-6887-9432 ; 0000-0001-7808-4943</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304603/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304603/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,881,1598,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38820132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533736$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:158609554$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Ingvarsson, P</contributor><creatorcontrib>Gong, Tong</creatorcontrib><creatorcontrib>Karlsson, Robert</creatorcontrib><creatorcontrib>Yao, Shuyang</creatorcontrib><creatorcontrib>Magnusson, Patrik K E</creatorcontrib><creatorcontrib>Ajnakina, Olesya</creatorcontrib><creatorcontrib>Steptoe, Andrew</creatorcontrib><creatorcontrib>Bhatta, Laxmi</creatorcontrib><creatorcontrib>Brumpton, Ben</creatorcontrib><creatorcontrib>Kumar, Ashish</creatorcontrib><creatorcontrib>Mélen, Erik</creatorcontrib><creatorcontrib>Lin, Keng-Han</creatorcontrib><creatorcontrib>Tian, Chao</creatorcontrib><creatorcontrib>Fall, Tove</creatorcontrib><creatorcontrib>Almqvist, Catarina</creatorcontrib><creatorcontrib>23andMe research team</creatorcontrib><title>The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals</title><title>G3 : genes - genomes - genetics</title><addtitle>G3 (Bethesda)</addtitle><description>Abstract
Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts and an additional 65,986 European-ancestry individuals in 3 replication cohorts from Sweden, Norway, and the United Kingdom. Association tests with >7.4 million single-nucleotide polymorphisms were meta-analyzed using a fixed effect model after controlling for population structure and relatedness. We identified 2 suggestive loci using discovery cohorts, which did not reach genome-wide significance after meta-analysis with replication cohorts. Single-nucleotide polymorphism-based heritability of dog ownership using linkage disequilibrium score regression was estimated at 0.123 (CI 0.038–0.207) using the discovery cohorts and 0.018 (CI −0.002 to 0.039) when adding in replication cohorts. Negative genetic correlation with complex traits including type 2 diabetes, depression, neuroticism, and asthma was only found using discovery summary data. Furthermore, we did not identify any genes/gene-sets reaching even a suggestive level of significance. This genome-wide association study does not, by itself, provide clear evidence on common genetic variants that influence dog ownership among European-ancestry individuals.</description><subject>Animals</subject><subject>dog ownership</subject><subject>Dogs</subject><subject>European ancestry</subject><subject>Female</subject><subject>Genome-Wide Association Study</subject><subject>GWAS</subject><subject>heritability</subject><subject>Humans</subject><subject>Investigation</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Ownership</subject><subject>Polymorphism, Single Nucleotide</subject><subject>replication</subject><subject>White People - genetics</subject><issn>2160-1836</issn><issn>2160-1836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNkk9vGyEQxVHVqoncfIBeKo49ZBtgdjHbSxUl6R8pUi9prwizs2ucNbiwxIrUD19Su25yqFQug5jfewPoEfKas3ectXA2wCrk6M14tro1yLl8Ro4Fl6ziCuTzR_sjcpLSipXVNFLW8iU5AqUE4yCOyc-bJdIBPU7OUhPt0k1opxyRhp52YaBh6zGmpdu8p6OJA1bJmvG3JKyx2roOqUkpWGcmFzxNU-7uqfO0nZ82jaBXOYYNGl8ZbzFN8aHXuTvXZTOmV-RFXwqe7OuMfPt4dXPxubr--unLxfl1ZaGtp2rRKwGMC26avm9rU7M5sEVrFVjZqcbw2ramRcF7hSgA5otagOAtrxtoeYcwI9XON21xkxd6E93axHsdjNP7o9uyQ63mTBTRjJz-k7903891iIPOWTdlFsiCf9jhhV1jZ9FP0YxPVE873i31EO4058BqyaA4vN07xPAjl3_Sa5csjqPxGHLSwCQUsFGqoHyH2hhSitgf5nCmH4KhD8HQ-2AUzZvHFzwo_sTg74ND3vyH3y9huckp</recordid><startdate>20240807</startdate><enddate>20240807</enddate><creator>Gong, Tong</creator><creator>Karlsson, Robert</creator><creator>Yao, Shuyang</creator><creator>Magnusson, Patrik K E</creator><creator>Ajnakina, Olesya</creator><creator>Steptoe, Andrew</creator><creator>Bhatta, Laxmi</creator><creator>Brumpton, Ben</creator><creator>Kumar, Ashish</creator><creator>Mélen, Erik</creator><creator>Lin, Keng-Han</creator><creator>Tian, Chao</creator><creator>Fall, Tove</creator><creator>Almqvist, Catarina</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-3987-1236</orcidid><orcidid>https://orcid.org/0000-0002-1045-1898</orcidid><orcidid>https://orcid.org/0000-0002-8949-2587</orcidid><orcidid>https://orcid.org/0000-0002-6887-9432</orcidid><orcidid>https://orcid.org/0000-0001-7808-4943</orcidid></search><sort><creationdate>20240807</creationdate><title>The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals</title><author>Gong, Tong ; Karlsson, Robert ; Yao, Shuyang ; Magnusson, Patrik K E ; Ajnakina, Olesya ; Steptoe, Andrew ; Bhatta, Laxmi ; Brumpton, Ben ; Kumar, Ashish ; Mélen, Erik ; Lin, Keng-Han ; Tian, Chao ; Fall, Tove ; Almqvist, Catarina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-bf8230121a5ff94a40730b9c83c6d85a14c9a9e21f8ee2337b423219145391de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>dog ownership</topic><topic>Dogs</topic><topic>European ancestry</topic><topic>Female</topic><topic>Genome-Wide Association Study</topic><topic>GWAS</topic><topic>heritability</topic><topic>Humans</topic><topic>Investigation</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Ownership</topic><topic>Polymorphism, Single Nucleotide</topic><topic>replication</topic><topic>White People - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gong, Tong</creatorcontrib><creatorcontrib>Karlsson, Robert</creatorcontrib><creatorcontrib>Yao, Shuyang</creatorcontrib><creatorcontrib>Magnusson, Patrik K E</creatorcontrib><creatorcontrib>Ajnakina, Olesya</creatorcontrib><creatorcontrib>Steptoe, Andrew</creatorcontrib><creatorcontrib>Bhatta, Laxmi</creatorcontrib><creatorcontrib>Brumpton, Ben</creatorcontrib><creatorcontrib>Kumar, Ashish</creatorcontrib><creatorcontrib>Mélen, Erik</creatorcontrib><creatorcontrib>Lin, Keng-Han</creatorcontrib><creatorcontrib>Tian, Chao</creatorcontrib><creatorcontrib>Fall, Tove</creatorcontrib><creatorcontrib>Almqvist, Catarina</creatorcontrib><creatorcontrib>23andMe research team</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>G3 : genes - genomes - genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gong, Tong</au><au>Karlsson, Robert</au><au>Yao, Shuyang</au><au>Magnusson, Patrik K E</au><au>Ajnakina, Olesya</au><au>Steptoe, Andrew</au><au>Bhatta, Laxmi</au><au>Brumpton, Ben</au><au>Kumar, Ashish</au><au>Mélen, Erik</au><au>Lin, Keng-Han</au><au>Tian, Chao</au><au>Fall, Tove</au><au>Almqvist, Catarina</au><au>Ingvarsson, P</au><aucorp>23andMe research team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals</atitle><jtitle>G3 : genes - genomes - genetics</jtitle><addtitle>G3 (Bethesda)</addtitle><date>2024-08-07</date><risdate>2024</risdate><volume>14</volume><issue>8</issue><issn>2160-1836</issn><eissn>2160-1836</eissn><abstract>Abstract
Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts and an additional 65,986 European-ancestry individuals in 3 replication cohorts from Sweden, Norway, and the United Kingdom. Association tests with >7.4 million single-nucleotide polymorphisms were meta-analyzed using a fixed effect model after controlling for population structure and relatedness. We identified 2 suggestive loci using discovery cohorts, which did not reach genome-wide significance after meta-analysis with replication cohorts. Single-nucleotide polymorphism-based heritability of dog ownership using linkage disequilibrium score regression was estimated at 0.123 (CI 0.038–0.207) using the discovery cohorts and 0.018 (CI −0.002 to 0.039) when adding in replication cohorts. Negative genetic correlation with complex traits including type 2 diabetes, depression, neuroticism, and asthma was only found using discovery summary data. Furthermore, we did not identify any genes/gene-sets reaching even a suggestive level of significance. This genome-wide association study does not, by itself, provide clear evidence on common genetic variants that influence dog ownership among European-ancestry individuals.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>38820132</pmid><doi>10.1093/g3journal/jkae116</doi><orcidid>https://orcid.org/0000-0003-3987-1236</orcidid><orcidid>https://orcid.org/0000-0002-1045-1898</orcidid><orcidid>https://orcid.org/0000-0002-8949-2587</orcidid><orcidid>https://orcid.org/0000-0002-6887-9432</orcidid><orcidid>https://orcid.org/0000-0001-7808-4943</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals dog ownership Dogs European ancestry Female Genome-Wide Association Study GWAS heritability Humans Investigation Linkage Disequilibrium Male Ownership Polymorphism, Single Nucleotide replication White People - genetics |
| title | The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals |
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