Adolescents on psychotropic treatment displayed longer corrected QT intervals than unmedicated controls when they rose rapidly from the supine position
Aim Psychotropic medication can contribute to arrhythmia and identifying individuals at risk is crucial. This Swedish study compared the corrected QT (QTc) intervals of adolescents on psychotropic medication with unmedicated controls, when supine and after rising rapidly. Methods The study was carri...
Gespeichert in:
| Veröffentlicht in: | ACTA PAEDIATRICA 2024-07, Vol.113 (7), p.1621-1629 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1629 |
|---|---|
| container_issue | 7 |
| container_start_page | 1621 |
| container_title | ACTA PAEDIATRICA |
| container_volume | 113 |
| creator | Berger, Vilma Bromée, Linn Lindam, Anna Hallin, Tove Reynisson, Björn Halldner Henriksson, Linda Naumburg, Estelle |
| description | Aim
Psychotropic medication can contribute to arrhythmia and identifying individuals at risk is crucial. This Swedish study compared the corrected QT (QTc) intervals of adolescents on psychotropic medication with unmedicated controls, when supine and after rising rapidly.
Methods
The study was carried out at Östersund County Hospital in March 2022 and February to March 2023. It comprised 16 cases, aged 10–17 years and 28 controls. QTc intervals were measured with electrocardiography and calculated using Bazett's and Fridericia's formulas. Univariate and multiple linear regressions were used to assess differences in QTc intervals between the cases and controls and across sex, age and body mass index.
Results
The mean QTc interval when supine, calculated with Bazett's formula, was longer for the adolescents on psychotropic medication than the controls (p = 0.046). The same was true for the mean QTc interval after rising rapidly from the supine position, calculated with both Bazett's formula (p = 0.009) and Fridericia's formula (p = 0.007). Mean QTc intervals varied by sex and age groups. Psychotropic medication prolonged QTc intervals, particularly in girls.
Conclusion
Longer QTc intervals were found in adolescents on psychotropic medication, particularly after rising rapidly from the supine position. |
| doi_str_mv | 10.1111/apa.17206 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_867924</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3066158093</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4246-541fab1d9df763ca6023fd562497578ccbbdbedd6d9578a3d99572d42e7fb7753</originalsourceid><addsrcrecordid>eNp9ks9u1DAQxiMEotvCgRdAlrjQQ1rbSezkuGr5J1UCpMLVcuxJ1yWxg52wypPwusySpQck8GXs-X76NDOeLHvB6AXDc6lHfcEkp-JRtmGiYjnnXD7ONrSmRV7xqjjJTlO6p5QXTSmeZidFXTHJqNxkP7c29JAM-CmR4MmYFrMLUwyjM2SKoKcBJWJdGnu9gCV98HcQiQkxgpkw8fmWOD9B_KH7RKad9mT2A1hn9EE1waMZKvsdeJRhITEkIFGPzvYL6WIYDmmS5tF5IGNIbnLBP8uedGgIz4_xLPvy9s3t1fv85uO7D1fbm9yUvBR5VbJOt8w2tpOiMFpgi52tBC8bWcnamLa1LVgrbINPXdgGI7clB9m1UlbFWZavvmkP49yqMbpBx0UF7dQx9Q1voGohG17-l792X7cqxDs1D7PivKCCIv965ccYvs-QJjU4nHbfaw9hToo3sqS0xIoRffUXeh_m6LF7hVaCVTVtCqTOV8rgHFOE7qEERtVhGxRug_q9Dci-PDrOLX7JA_nn-xG4XIG962H5t5Paftqulr8AAAvCqA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3066158093</pqid></control><display><type>article</type><title>Adolescents on psychotropic treatment displayed longer corrected QT intervals than unmedicated controls when they rose rapidly from the supine position</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SWEPUB Freely available online</source><source>Wiley-Blackwell Open Access Titles</source><source>Alma/SFX Local Collection</source><creator>Berger, Vilma ; Bromée, Linn ; Lindam, Anna ; Hallin, Tove ; Reynisson, Björn ; Halldner Henriksson, Linda ; Naumburg, Estelle</creator><creatorcontrib>Berger, Vilma ; Bromée, Linn ; Lindam, Anna ; Hallin, Tove ; Reynisson, Björn ; Halldner Henriksson, Linda ; Naumburg, Estelle</creatorcontrib><description>Aim
Psychotropic medication can contribute to arrhythmia and identifying individuals at risk is crucial. This Swedish study compared the corrected QT (QTc) intervals of adolescents on psychotropic medication with unmedicated controls, when supine and after rising rapidly.
Methods
The study was carried out at Östersund County Hospital in March 2022 and February to March 2023. It comprised 16 cases, aged 10–17 years and 28 controls. QTc intervals were measured with electrocardiography and calculated using Bazett's and Fridericia's formulas. Univariate and multiple linear regressions were used to assess differences in QTc intervals between the cases and controls and across sex, age and body mass index.
Results
The mean QTc interval when supine, calculated with Bazett's formula, was longer for the adolescents on psychotropic medication than the controls (p = 0.046). The same was true for the mean QTc interval after rising rapidly from the supine position, calculated with both Bazett's formula (p = 0.009) and Fridericia's formula (p = 0.007). Mean QTc intervals varied by sex and age groups. Psychotropic medication prolonged QTc intervals, particularly in girls.
Conclusion
Longer QTc intervals were found in adolescents on psychotropic medication, particularly after rising rapidly from the supine position.</description><identifier>ISSN: 0803-5253</identifier><identifier>ISSN: 1651-2227</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/apa.17206</identifier><identifier>PMID: 38517107</identifier><language>eng</language><publisher>Norway: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adolescents ; Arrhythmia ; Body mass index ; cardiac assessment ; Case-Control Studies ; Child ; corrected QT intervals ; EKG ; Electrocardiography ; Female ; Humans ; Long QT Syndrome - chemically induced ; Male ; Psychotropic drugs ; Psychotropic Drugs - adverse effects ; Psychotropic Drugs - therapeutic use ; psychotropic medicine ; Supine Position ; Teenagers</subject><ispartof>ACTA PAEDIATRICA, 2024-07, Vol.113 (7), p.1621-1629</ispartof><rights>2024 The Authors. published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.</rights><rights>2024 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4246-541fab1d9df763ca6023fd562497578ccbbdbedd6d9578a3d99572d42e7fb7753</cites><orcidid>0000-0001-6090-494X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapa.17206$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapa.17206$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,778,782,883,1414,11549,27911,27912,45561,45562,46039,46463</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38517107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223060$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:155214959$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Berger, Vilma</creatorcontrib><creatorcontrib>Bromée, Linn</creatorcontrib><creatorcontrib>Lindam, Anna</creatorcontrib><creatorcontrib>Hallin, Tove</creatorcontrib><creatorcontrib>Reynisson, Björn</creatorcontrib><creatorcontrib>Halldner Henriksson, Linda</creatorcontrib><creatorcontrib>Naumburg, Estelle</creatorcontrib><title>Adolescents on psychotropic treatment displayed longer corrected QT intervals than unmedicated controls when they rose rapidly from the supine position</title><title>ACTA PAEDIATRICA</title><addtitle>Acta Paediatr</addtitle><description>Aim
Psychotropic medication can contribute to arrhythmia and identifying individuals at risk is crucial. This Swedish study compared the corrected QT (QTc) intervals of adolescents on psychotropic medication with unmedicated controls, when supine and after rising rapidly.
Methods
The study was carried out at Östersund County Hospital in March 2022 and February to March 2023. It comprised 16 cases, aged 10–17 years and 28 controls. QTc intervals were measured with electrocardiography and calculated using Bazett's and Fridericia's formulas. Univariate and multiple linear regressions were used to assess differences in QTc intervals between the cases and controls and across sex, age and body mass index.
Results
The mean QTc interval when supine, calculated with Bazett's formula, was longer for the adolescents on psychotropic medication than the controls (p = 0.046). The same was true for the mean QTc interval after rising rapidly from the supine position, calculated with both Bazett's formula (p = 0.009) and Fridericia's formula (p = 0.007). Mean QTc intervals varied by sex and age groups. Psychotropic medication prolonged QTc intervals, particularly in girls.
Conclusion
Longer QTc intervals were found in adolescents on psychotropic medication, particularly after rising rapidly from the supine position.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Arrhythmia</subject><subject>Body mass index</subject><subject>cardiac assessment</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>corrected QT intervals</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Humans</subject><subject>Long QT Syndrome - chemically induced</subject><subject>Male</subject><subject>Psychotropic drugs</subject><subject>Psychotropic Drugs - adverse effects</subject><subject>Psychotropic Drugs - therapeutic use</subject><subject>psychotropic medicine</subject><subject>Supine Position</subject><subject>Teenagers</subject><issn>0803-5253</issn><issn>1651-2227</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9ks9u1DAQxiMEotvCgRdAlrjQQ1rbSezkuGr5J1UCpMLVcuxJ1yWxg52wypPwusySpQck8GXs-X76NDOeLHvB6AXDc6lHfcEkp-JRtmGiYjnnXD7ONrSmRV7xqjjJTlO6p5QXTSmeZidFXTHJqNxkP7c29JAM-CmR4MmYFrMLUwyjM2SKoKcBJWJdGnu9gCV98HcQiQkxgpkw8fmWOD9B_KH7RKad9mT2A1hn9EE1waMZKvsdeJRhITEkIFGPzvYL6WIYDmmS5tF5IGNIbnLBP8uedGgIz4_xLPvy9s3t1fv85uO7D1fbm9yUvBR5VbJOt8w2tpOiMFpgi52tBC8bWcnamLa1LVgrbINPXdgGI7clB9m1UlbFWZavvmkP49yqMbpBx0UF7dQx9Q1voGohG17-l792X7cqxDs1D7PivKCCIv965ccYvs-QJjU4nHbfaw9hToo3sqS0xIoRffUXeh_m6LF7hVaCVTVtCqTOV8rgHFOE7qEERtVhGxRug_q9Dci-PDrOLX7JA_nn-xG4XIG962H5t5Paftqulr8AAAvCqA</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Berger, Vilma</creator><creator>Bromée, Linn</creator><creator>Lindam, Anna</creator><creator>Hallin, Tove</creator><creator>Reynisson, Björn</creator><creator>Halldner Henriksson, Linda</creator><creator>Naumburg, Estelle</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>ADHXS</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D93</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0001-6090-494X</orcidid></search><sort><creationdate>202407</creationdate><title>Adolescents on psychotropic treatment displayed longer corrected QT intervals than unmedicated controls when they rose rapidly from the supine position</title><author>Berger, Vilma ; Bromée, Linn ; Lindam, Anna ; Hallin, Tove ; Reynisson, Björn ; Halldner Henriksson, Linda ; Naumburg, Estelle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4246-541fab1d9df763ca6023fd562497578ccbbdbedd6d9578a3d99572d42e7fb7753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Arrhythmia</topic><topic>Body mass index</topic><topic>cardiac assessment</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>corrected QT intervals</topic><topic>EKG</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Humans</topic><topic>Long QT Syndrome - chemically induced</topic><topic>Male</topic><topic>Psychotropic drugs</topic><topic>Psychotropic Drugs - adverse effects</topic><topic>Psychotropic Drugs - therapeutic use</topic><topic>psychotropic medicine</topic><topic>Supine Position</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berger, Vilma</creatorcontrib><creatorcontrib>Bromée, Linn</creatorcontrib><creatorcontrib>Lindam, Anna</creatorcontrib><creatorcontrib>Hallin, Tove</creatorcontrib><creatorcontrib>Reynisson, Björn</creatorcontrib><creatorcontrib>Halldner Henriksson, Linda</creatorcontrib><creatorcontrib>Naumburg, Estelle</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>SWEPUB Umeå universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Umeå universitet</collection><collection>SwePub Articles full text</collection><jtitle>ACTA PAEDIATRICA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berger, Vilma</au><au>Bromée, Linn</au><au>Lindam, Anna</au><au>Hallin, Tove</au><au>Reynisson, Björn</au><au>Halldner Henriksson, Linda</au><au>Naumburg, Estelle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adolescents on psychotropic treatment displayed longer corrected QT intervals than unmedicated controls when they rose rapidly from the supine position</atitle><jtitle>ACTA PAEDIATRICA</jtitle><addtitle>Acta Paediatr</addtitle><date>2024-07</date><risdate>2024</risdate><volume>113</volume><issue>7</issue><spage>1621</spage><epage>1629</epage><pages>1621-1629</pages><issn>0803-5253</issn><issn>1651-2227</issn><eissn>1651-2227</eissn><abstract>Aim
Psychotropic medication can contribute to arrhythmia and identifying individuals at risk is crucial. This Swedish study compared the corrected QT (QTc) intervals of adolescents on psychotropic medication with unmedicated controls, when supine and after rising rapidly.
Methods
The study was carried out at Östersund County Hospital in March 2022 and February to March 2023. It comprised 16 cases, aged 10–17 years and 28 controls. QTc intervals were measured with electrocardiography and calculated using Bazett's and Fridericia's formulas. Univariate and multiple linear regressions were used to assess differences in QTc intervals between the cases and controls and across sex, age and body mass index.
Results
The mean QTc interval when supine, calculated with Bazett's formula, was longer for the adolescents on psychotropic medication than the controls (p = 0.046). The same was true for the mean QTc interval after rising rapidly from the supine position, calculated with both Bazett's formula (p = 0.009) and Fridericia's formula (p = 0.007). Mean QTc intervals varied by sex and age groups. Psychotropic medication prolonged QTc intervals, particularly in girls.
Conclusion
Longer QTc intervals were found in adolescents on psychotropic medication, particularly after rising rapidly from the supine position.</abstract><cop>Norway</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38517107</pmid><doi>10.1111/apa.17206</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6090-494X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0803-5253 |
| ispartof | ACTA PAEDIATRICA, 2024-07, Vol.113 (7), p.1621-1629 |
| issn | 0803-5253 1651-2227 1651-2227 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_867924 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online; Wiley-Blackwell Open Access Titles; Alma/SFX Local Collection |
| subjects | Adolescent Adolescents Arrhythmia Body mass index cardiac assessment Case-Control Studies Child corrected QT intervals EKG Electrocardiography Female Humans Long QT Syndrome - chemically induced Male Psychotropic drugs Psychotropic Drugs - adverse effects Psychotropic Drugs - therapeutic use psychotropic medicine Supine Position Teenagers |
| title | Adolescents on psychotropic treatment displayed longer corrected QT intervals than unmedicated controls when they rose rapidly from the supine position |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T05%3A41%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adolescents%20on%20psychotropic%20treatment%20displayed%20longer%20corrected%20QT%20intervals%20than%20unmedicated%20controls%20when%20they%20rose%20rapidly%20from%20the%20supine%20position&rft.jtitle=ACTA%20PAEDIATRICA&rft.au=Berger,%20Vilma&rft.date=2024-07&rft.volume=113&rft.issue=7&rft.spage=1621&rft.epage=1629&rft.pages=1621-1629&rft.issn=0803-5253&rft.eissn=1651-2227&rft_id=info:doi/10.1111/apa.17206&rft_dat=%3Cproquest_swepu%3E3066158093%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3066158093&rft_id=info:pmid/38517107&rfr_iscdi=true |