L-arginine metabolism inhibits arthritis and inflammatory bone loss

ObjectivesTo investigate the effect of the L-arginine metabolism on arthritis and inflammation-mediated bone loss.MethodsL-arginine was applied to three arthritis models (collagen-induced arthritis, serum-induced arthritis and human TNF transgenic mice). Inflammation was assessed clinically and hist...

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Veröffentlicht in:	Annals of the rheumatic diseases 2024-01, Vol.83 (1), p.72-87
Hauptverfasser:	Cao, Shan, Li, Yixuan, Song, Rui, Meng, Xianyi, Fuchs, Maximilian, Liang, Chunguang, Kachler, Katerina, Meng, Xinyu, Wen, Jinming, Schlötzer-Schrehardt, Ursula, Taudte, Verena, Gessner, Arne, Kunz, Meik, Schleicher, Ulrike, Zaiss, Mario M, Kastbom, Alf, Chen, Xiaoxiang, Schett, Georg, Bozec, Aline
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine deaminase Amino acids Animals Arginine Arginine - pharmacology Arthritis Arthritis, Experimental - pathology Arthritis, Rheumatoid - pathology Bone loss Bone Resorption Dietary supplements Genomes Glycolysis Humans Hypoxanthine Hypoxanthines - metabolism Hypoxanthines - pharmacology Inflammation Inflammation - metabolism Inflammatory Arthritis Inosine - metabolism Inosine - pharmacology Mass spectrometry Mass spectroscopy Metabolism Mice Mice, Transgenic Nitric oxide Osteoclastogenesis Osteoclasts Osteoporosis Oxidative phosphorylation Phosphorylation Proteins Purines - pharmacology Respiration Rheumatoid arthritis Scientific imaging Transgenic mice Transmission electron microscopy
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