CD19 Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus

B cell generation of autoantibodies is a crucial step in the pathogenesis of systemic lupus erythematosus (SLE). After their differentiation in the bone marrow, B cells populate the secondary lymphatic organs, where they undergo further maturation leading to the development of memory B cells as well...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2024-04, Vol.76 (4), p.497-504
Hauptverfasser:	Taubmann, Jule, Müller, Fabian, Yalcin Mutlu, Melek, Völkl, Simon, Aigner, Michael, Bozec, Aline, Mackensen, Andreas, Grieshaber‐Bouyer, Ricardo, Schett, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Autoantibodies Autoimmune diseases Bone marrow CD19 antigen Cell activation Chimeric antigen receptors Chronic conditions Depletion Health services Immunological memory Immunological tolerance Lupus Lymphocytes Lymphocytes B Lymphocytes T Memory cells Pathogenesis Plasma cells Receptors Systemic lupus erythematosus
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